Patents Assigned to Pluristem Ltd.
  • METHODS AND COMPOSITIONS FOR TUMOR ASSESSMENT
    Publication number: 20200080147
    Abstract: Described herein are methods and articles of manufacture for determining the suitability of a tumor or neoplastic cell to treatment with adherent stromal cells or with conditioned medium derived therefrom.
    Type: Application
    Filed: February 18, 2018
    Publication date: March 12, 2020
    Applicant: PLURISTEM LTD.
    Inventors: Zami ABERMAN, Rachel OFIR, Hoshea Yissachar ALLEN
  • Systems and methods for growing and harvesting cells
    Patent number: 10392593
    Abstract: This disclosure is directed to methods and systems for growing and/or harvesting cells. The method can include seeding cells on a plurality of carriers. The method can also include incubating the carriers under conditions suitable for cell growth.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: August 27, 2019
    Assignee: PLURISTEM LTD.
    Inventors: Harel Kasuto, Ohad Karnieli, Dotan Hoffman, Lior Raviv
  • Gene and protein expression properties of adherent stromal cells cultured in 3D
    Patent number: 10351910
    Abstract: Adherent stromal cells cultured under three dimensional conditions are provided, characterized, and distinguished from adherent stromal cells cultured under two dimensional conditions.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: July 16, 2019
    Assignee: PLURISTEM LTD
    Inventors: Rachel Ofir, Eytan Abraham
  • Methods and compositions for treating and preventing muscle wasting disorders
    Patent number: 10258652
    Abstract: Described herein are methods of treating and preventing muscle wasting and muscle loss, using adherent stromal cells and conditioned medium produced thereby.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 16, 2019
    Assignee: PLURISTEM LTD.
    Inventors: Esther Lukasiewicz Hagai, Rachel Ofir, Dana Fuchs Telem
  • Method and device for thawing biological material
    Patent number: 10251389
    Abstract: This disclosure is a system for heating a sample, e.g. a biological material, in a vessel. The system can include a heating device configured to transmit energy to the vessel and a base moveably coupled to the heating device. The system can also include a processor configured to receive an input associated with a target temperature, and transmit a signal to controllably move the heating device relative to the base for a time period, wherein the time period is determined based on the target temperature and content volume.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: April 9, 2019
    Assignee: PLURISTEM LTD.
    Inventors: Ohad Karnieli, Tal Slonim, Lior Raviv, Nufar Gross
  • ADHERENT CELLS FROM ADIPOSE OR PLACENTA TISSUES AND USE THEREOF IN THERAPY
    Publication number: 20180256648
    Abstract: A method of treating ischemia in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of adherent cells of a tissue selected from the group consisting of a placenta and an adipose tissue, thereby treating the ischemia in the subject. A method of treating a medical condition requiring connective tissue regeneration and/or repair is also disclosed.
    Type: Application
    Filed: August 5, 2013
    Publication date: September 13, 2018
    Applicant: Pluristem Ltd.
    Inventors: Moran Meiron, Amir Toren, Rachel Ofir, Zami Aberman, Nirit Drori-Carmi
  • Methods for prevention and treatment of preeclampsia
    Patent number: 9950014
    Abstract: Methods for treating or preventing preeclampsia or eclampsia by administering adherent stromal cells are described. The adherent stromal cells may be derived from bone marrow, placenta, or adipose tissue. Also described is the use of adherent stromal cells for the manufacture of a medicament, and an article of manufacture comprising a packaging material which comprises a label for use in treating or preventing preeclampsia or eclampsia.
    Type: Grant
    Filed: August 31, 2013
    Date of Patent: April 24, 2018
    Assignee: PLURISTEM LTD.
    Inventors: Ayelet Chajut, Eytan Abraham
  • Perfusion bioreactor for culturing CD200—placenta adherent cells
    Patent number: 9758762
    Abstract: A method of culturing adherent cells from a placenta or adipose tissue is disclosed. The method comprises culturing the adherent cells from the placenta or adipose tissue under 3 dimensional (3D) culturing conditions which allow cell expansion, the conditions comprising perfusion.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: September 12, 2017
    Assignee: Pluristem Ltd.
    Inventors: Moran Meiron, Amir Toren, Racheli Ofir, Nirit Drori-Carmi
  • Skeletal muscle regeneration using mesenchymal system cells
    Patent number: 9757419
    Abstract: The present invention relates to a therapeutic substance and/or medicament and methods relating to the use of said substance and/or medicament for skeletal muscle regeneration using mesenchymal stem cells (MSCs) which can be applied directly or shortly after muscle damage or injury.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: September 12, 2017
    Assignee: Pluristem Ltd.
    Inventors: Georg Duda, Tobias Winkler, Georg Matziolis, Philipp Von Roth, Carsten Perka
  • Methods and systems for harvesting cells
    Patent number: 9657266
    Abstract: Methods for using vibration to harvest cells grown in 3D culture are provided. The methods entail the application of force to cells attached to a 3D matrix of sufficient amplitude, frequency, and duration to detach cells from the matrix and to flush the detached cells out of the matrix material. An apparatus for performing the methods of the invention as provided.
    Type: Grant
    Filed: April 15, 2012
    Date of Patent: May 23, 2017
    Assignee: Pluristem Ltd.
    Inventors: Harel Kasuto, Nirit Drori-Carmi, Barak Zohar
  • SYSTEMS AND METHODS FOR GROWING AND HARVESTING CELLS
    Publication number: 20170073625
    Abstract: This disclosure is directed to methods and systems for growing and/or harvesting cells. The method can include seeding cells on a plurality of carriers. The method can also include incubating the carriers under conditions suitable for cell growth.
    Type: Application
    Filed: March 3, 2015
    Publication date: March 16, 2017
    Applicant: Pluristem Ltd.
    Inventors: Harel Kasuto, Ohad Karnieli, Dotan Hoffman, Lior Raviv
  • Adherent cells from adipose or placenta tissues and use thereof in therapy
    Patent number: 9517248
    Abstract: A method of treating ischemia in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of adherent cells of a tissue selected from the group consisting of a placenta and an adipose tissue, thereby treating the ischemia in the subject. A method of treating a medical condition requiring connective tissue regeneration and/or repair is also disclosed.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: December 13, 2016
    Assignee: Pluristem Ltd.
    Inventors: Moran Meiron, Amir Toren, Rachel Ofir, Zami Aberman, Nirit Drori-Carmi
  • Devices and methods for culture of cells
    Patent number: 9512393
    Abstract: Devices and methods for culture of cells are provided. The devices can comprise a three-dimensional body having multiple two-dimensional surfaces extending inwardly from a periphery of the three-dimensional body towards an interior of the three-dimensional body, wherein the multiple two-dimensional surfaces are configured to support monolayer growth of eukaryotic cells over at least a majority of or all of the surface area of the multiple two-dimensional surfaces.
    Type: Grant
    Filed: August 31, 2013
    Date of Patent: December 6, 2016
    Assignee: Pluristem Ltd.
    Inventors: Harel Kasuto, Eytan Abraham, Zami Aberman
  • METHODS OF TREATING INFLAMMATORY COLON DISEASES
    Publication number: 20160271184
    Abstract: A method of treating ulcerative colitis or Crohn's disease in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of adherent cells from a placenta or adipose tissue, thereby treating the ulcerative colitis or Crohn's disease.
    Type: Application
    Filed: March 28, 2016
    Publication date: September 22, 2016
    Applicant: PLURISTEM LTD.
    Inventor: Moran Meiron
  • Methods of treating inflammatory colon diseases
    Patent number: 9393273
    Abstract: A method of treating ulcerative colitis or Crohn's disease in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of adherent cells from a placenta or adipose tissue, thereby treating the ulcerative colitis or Crohn's disease.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 19, 2016
    Assignee: Pluristem Ltd.
    Inventor: Moran Meiron
  • GENE AND PROTEIN EXPRESSION PROPERTIES OF ADHERENT STROMAL CELLS CULTURED IN 3D
    Publication number: 20160186259
    Abstract: Adherent stromal cells cultured under three dimensional conditions are provided, characterized, and distinguished from adherent stromal cells cultured under two dimensional conditions.
    Type: Application
    Filed: February 20, 2014
    Publication date: June 30, 2016
    Applicant: Pluristem Ltd.
    Inventors: Rachel Ofir, Eytan Abraham
  • ADHERENT CELLS FROM PLACENTA AND USE OF SAME IN DISEASE TREATMENT
    Publication number: 20160058799
    Abstract: Methods for treating conditions by administration of placenta derived adherent stromal cells to a subject in thereof are provided. Such conditions include skeletal muscle defects, neuropathic pain, and myocardial infarction. Also provided are methods wherein the adherent stromal cells administered are cultured under 2 dimensional or 3 dimensional growth conditions. Also provided are methods in which the cells administered are at least 70% adherent cells from a maternal or fetal portion of the placenta.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 3, 2016
    Applicant: Pluristem Ltd.
    Inventor: Zami Aberman
  • METHODS FOR CELL EXPANSION AND USES OF CELLS AND CONDITIONED MEDIA PRODUCED THEREBY FOR THERAPY
    Publication number: 20160022738
    Abstract: A method of cell expansion is provided. The method comprising culturing adherent cells from placenta or adipose tissue under three-dimensional culturing conditions, which support cell expansion.
    Type: Application
    Filed: October 1, 2015
    Publication date: January 28, 2016
    Applicant: Pluristem Ltd.
    Inventors: Shai Meretski, Zami Aberman, Ora Burger
  • Carrier for cell culture
    Patent number: D800334
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: October 17, 2017
    Assignee: Pluristem Ltd.
    Inventors: Harel Kasuto, Eytan Abraham
  • Carrier for cell culture
    Patent number: D802157
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: November 7, 2017
    Assignee: Pluristem Ltd.
    Inventors: Harel Kasuto, Eytan Abraham