Patents Assigned to POLYMEDIX
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Publication number: 20130274502Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 19, 2012Publication date: October 17, 2013Applicant: PolyMedix, Inc.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Publication number: 20130252964Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.Type: ApplicationFiled: January 18, 2013Publication date: September 26, 2013Applicant: PolyMedix, Inc.Inventors: Richard W. Scott, Katie Freeman, Haizhong Tang, Gill Diamond
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Patent number: 8507723Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: June 21, 2012Date of Patent: August 13, 2013Assignee: Polymedix, Inc.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20130137706Abstract: The present invention provides methods of inhibiting the growth of Mycobacterium species or treating an animal having a Mycobacterium infection (including multi-drug resistance strains and extensively drug resistant strains) by administering a compound of the invention, a salt thereof, or a composition comprising the same.Type: ApplicationFiled: October 23, 2012Publication date: May 30, 2013Applicant: POLYMEDIX, INC.Inventor: POLYMEDIX, INC.
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Publication number: 20130090345Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.Type: ApplicationFiled: August 1, 2012Publication date: April 11, 2013Applicant: POLYMEDIX, INC.Inventors: Willam F. DeGrado, Haizhong Tang, Bozena Korczak, Dahui Liu, Richard W. Scott, Yongjiang Xu
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Publication number: 20130065818Abstract: The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.Type: ApplicationFiled: October 26, 2012Publication date: March 14, 2013Applicant: POLYMEDIXInventor: PolyMedix
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Patent number: 8354556Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: GrantFiled: October 21, 2010Date of Patent: January 15, 2013Assignee: PolyMedix, Inc.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Publication number: 20120322878Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: ApplicationFiled: June 21, 2012Publication date: December 20, 2012Applicant: POLYMEDIX, INC.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20120295922Abstract: The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.Type: ApplicationFiled: May 15, 2012Publication date: November 22, 2012Applicant: POLYMEDIX, INC.Inventors: Richard W. Scott, Bozena Korczak
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Publication number: 20120258141Abstract: The present invention provides compounds and compositions thereof that modulate the immune system.Type: ApplicationFiled: July 6, 2011Publication date: October 11, 2012Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, POLYMEDIX, INC.Inventors: Richard W. Scott, Gill Diamond
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Patent number: 8278309Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.Type: GrantFiled: October 26, 2009Date of Patent: October 2, 2012Assignee: PolyMedix, Inc.Inventors: William F. DeGrado, Dahui Liu, Richard W. Scott, Yongjiang Xu, Haizhong Tang, Bozena Korczak
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Patent number: 8232428Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: March 10, 2010Date of Patent: July 31, 2012Assignee: PolyMedix,Inc.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20120115877Abstract: The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.Type: ApplicationFiled: August 20, 2011Publication date: May 10, 2012Applicant: POLYMEDIX, INC.Inventors: Richard W. Scott, Dylan Clements, Yongjiang Xu, Haizhong Tang, Carol Mulrooney, Ehab Khalil, Damian Weaver, Xiaodong Fan
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Patent number: 8129566Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: December 17, 2010Date of Patent: March 6, 2012Assignee: PolyMedix, Inc.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20120039945Abstract: The present invention provides compounds and compositions thereof that modulate the immune system.Type: ApplicationFiled: July 6, 2011Publication date: February 16, 2012Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, POLYMEDIX, INC.Inventors: Richard W. Scott, Gill Diamond
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Publication number: 20110178104Abstract: The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a salt thereof, or a composition comprising the same.Type: ApplicationFiled: January 5, 2011Publication date: July 21, 2011Applicant: POLYMEDIX INC.Inventors: Richard W. Scott, Dahui Liu, Robert W. Kavash, Trevor Young, Michael J. Costanzo, Carol Ann Mulrooney
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Publication number: 20110124664Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: ApplicationFiled: December 17, 2010Publication date: May 26, 2011Applicant: POLYMEDIX, INC.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20110098498Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: ApplicationFiled: October 21, 2010Publication date: April 28, 2011Applicant: POLYMEDIX, INC.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Patent number: 7745662Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: May 14, 2009Date of Patent: June 29, 2010Assignee: Polymedix, Inc.Inventor: Mousa Shaker
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Publication number: 20100105703Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.Type: ApplicationFiled: October 26, 2009Publication date: April 29, 2010Applicant: POLYMEDIX, INC.Inventors: William F. DeGrado, Dahui Liu, Richard W. Scott, Yongjiang Xu, Haizhong Tang, Bozena Korczak