Patents Assigned to Portela, C.A., S.A.
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Patent number: 10912781Abstract: A pharmaceutical composition comprising licarbazepine acetate, especially eslicarbazepine acetate, in combination with suitable excipients, in particular a binder, and a disintegrant. Also disclosed is a granulation process, especially a wet granulation process, for making the pharmaceutical composition.Type: GrantFiled: January 4, 2017Date of Patent: February 9, 2021Assignee: BIAL-Portela & C.A., S.A.Inventors: Teöfilo Cardoso de Vasconcelos, Ricardo Jorge dos Santos Lima, Rui Cerdeira de Campos Costa
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Patent number: 10501447Abstract: A compound having a structure selected from the following: or a pharmaceutically acceptable salt thereof. The compound may be used as an inhibitor of fatty acid amide hydrolase.Type: GrantFiled: July 24, 2014Date of Patent: December 10, 2019Assignee: BIAL-PORTELA & Cᵃ, S.A.Inventors: Carla Patrícia Da Costa Pereira Rosa, Rita Gusmão De Noronha, Laszlo Erno Kiss
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Publication number: 20140343043Abstract: A pharmaceutical composition comprising licarbazepine acetate, especially eslicarbazepine acetate, in combination with suitable excipients, in particular a binder, and a disintegrant. Also disclosed is a granulation process, especially a wet granulation process, for making the pharmaceutical composition.Type: ApplicationFiled: December 17, 2013Publication date: November 20, 2014Applicant: BIAL - PORTELA & C.A., S.A.Inventors: Teófilo Cardoso de Vasconcelos, Ricardo Jorge dos Santos Lima, Rui Cerdeira de Campos Costa
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Patent number: 8859815Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.Type: GrantFiled: December 7, 2011Date of Patent: October 14, 2014Assignee: Bial-Portela & C.A., S.A.Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
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Publication number: 20130150348Abstract: A pharmaceutical composition comprising licarbazepine acetate, especially eslicarbazepine acetate, in combination with suitable excipients, in particular a binder, and a disintegrant. Also disclosed is a granulation process, especially a wet granulation process, for making the pharmaceutical composition.Type: ApplicationFiled: January 30, 2013Publication date: June 13, 2013Applicant: BIAL - PORTELA & C.A., S.A.Inventor: BIAL - PORTELA & C.A., S.A.
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Publication number: 20130041146Abstract: A process for preparing (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide or (R)-(?)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide, by reduction of oxcarbazepine in the presence of a catalyst and a hydride source is disclosed. The catalyst is prepared from a combination of [RuX2(L)]2 wherein X is chlorine, bromine or iodine, and L is an aryl or aryl-aliphatic ligand, with a ligand of formula (A) or formula (B): wherein R1 is chosen from C1-6 alkoxy and C1-6 alkyl, n is a number from 0 to 5, and when n is a number from 2 to 5, R1 can be the same or different, and R2 is alkyl, substituted alkyl, aryl, substituted aryl, alkaryl or substituted alkaryl. The hydride source is either NR3R4R5 and formic acid, [R3R4R5NH][OOCH] and optionally formic acid, or [M][OOCH]x and formic acid, wherein R3, R4 and R5 are C1-6 alkyl, M is an alkali metal or alkaline earth metal and x is 1 or 2. A pH from 6.5 to 8 is maintained during the process.Type: ApplicationFiled: October 15, 2012Publication date: February 14, 2013Applicant: BIAL - PORTELA & C.A., S.A.Inventor: BIAL - PORTELA & C.A., S.A.
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Patent number: 8372431Abstract: A pharmaceutical composition comprising licarbazepine acetate, especially eslicarbazepine acetate, in combination with suitable excipients, in particular a binder, and a disintegrant. Also disclosed is a granulation process, especially a wet granulation process, for making the pharmaceutical composition.Type: GrantFiled: October 23, 2008Date of Patent: February 12, 2013Assignee: BIAL-Portela & C.A., S.A.Inventors: Teófilo Cardoso de Vasconcelos, Ricardo Jorge dos Santos Lima, Rui Cerdeira de Campos Costa
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Patent number: 8158666Abstract: A process for making (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione and pharmaceutically acceptable salts thereof, and for making intermediates useful in the formation of said compound.Type: GrantFiled: January 31, 2008Date of Patent: April 17, 2012Assignee: Bial-Portela & C.A., S.A.Inventors: Patrício Manuel Vieira Araújo Soares Da Silva, Alexander Beliaev, David Alexander Learmonth
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Patent number: 7820813Abstract: An efficient and high-yielding method for the preparation of optically pure (S)-(+)-10,11 -dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and (R)-(?)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by resolution of racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide using a tartaric acid anhydride.Type: GrantFiled: September 25, 2006Date of Patent: October 26, 2010Assignee: Portela & C.A., S.A.Inventor: David Alexander Learmonth
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Publication number: 20080139807Abstract: A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (1) by ring opening of 11a,10b-dihydro-6H-dibenz/b,f/oxireno[d]azepine-6-carboxamide (5), characterised in that the ring opening is carried out under conditions of elevated pressure.Type: ApplicationFiled: January 13, 2006Publication date: June 12, 2008Applicant: PORTELA & C.A.,S.A.Inventors: David Alexander Learmonth, Gunter Weingartner, Matthias Kraemer
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Patent number: 7259271Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.Type: GrantFiled: September 20, 2006Date of Patent: August 21, 2007Assignee: Portela & C.A., S.A.Inventors: David Alexander Learmonth, Patricio Manuel Viera Araújo Soares da Silva, Alexander Beliaev
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Patent number: 7241886Abstract: A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step process involving (i) epoxidation of carbamazepine; (ii) ring-opening of the resulting epoxide and (iii) oxidation of the resulting alcoholType: GrantFiled: May 22, 2002Date of Patent: July 10, 2007Assignee: Portela & C.A., S.A.Inventor: David Alexander Learmonth
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Patent number: 7189846Abstract: A high-yielding method and a useful intermediate, 10-chloro-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (VII) is disclosed. Also disclosed are methods for the racemization of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (I) and (R)-(?)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (II) to racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (III).Type: GrantFiled: May 10, 2004Date of Patent: March 13, 2007Assignee: Portela & C.A., S.A.Inventor: David Alexander Learmonth
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Publication number: 20070015730Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.Type: ApplicationFiled: September 20, 2006Publication date: January 18, 2007Applicant: PORTELA & C.A., S.A.Inventors: David Learmonth, Patricio Manuel Viera Araujo Soares da Silva, Alexander Beliaev
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Patent number: 7125904Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.Type: GrantFiled: October 8, 2003Date of Patent: October 24, 2006Assignee: Portela & C.A., S.A.Inventors: David Alexander Learmonth, Patricio Manuel Viera Araújo Soares da Silva, Alexander Beliaev
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Patent number: 7119197Abstract: An efficient and high-yielding method for the preparation of optically pure (S)-(+) -10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and (R)-(?)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by resolution of racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide using a tartaric acid anhydride.Type: GrantFiled: May 10, 2002Date of Patent: October 10, 2006Assignee: Portela & C.A., S.A.Inventor: David Alexander Learmonth
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Patent number: 7005553Abstract: A method for the regioselective ortho-directed nitration of phenolic compounds useful for the preparation of ortho-nitro-phenols according to formula (I) is described.Type: GrantFiled: July 22, 2002Date of Patent: February 28, 2006Assignee: Portela, C.A., S.A.Inventor: David Alexander Learmonth
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Publication number: 20040142996Abstract: Compounds of formula I: t,0010Type: ApplicationFiled: October 8, 2003Publication date: July 22, 2004Applicant: Portela & C.A., S.A.Inventors: David Alexander Learmonth, Patricio Manuel Viera Araujo Soares da Silva, Alexander Beliaev
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Patent number: 6512136Abstract: New compounds of formula I are described The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders, where a reduction in the O-methylation of catecholamines may be of therapeutical benefit, such as Parkinson's disease and parkinsonian disorders, gastrointestinal disturbances, edema formation states and hypertension.Type: GrantFiled: December 17, 1999Date of Patent: January 28, 2003Assignee: Portela & C.A., S.A.Inventors: Jan Benes, Patricio Manuel Viera Araujo Soares Da Silva, David Alexander Learmonth