Patents Assigned to PORTON FINE CHEMICALS LTD.
  • Rosuvastatin calcium intermediate and method for preparing the same
    Patent number: 8933269
    Abstract: A method for preparing a rosuvastatin calcium intermediate, including a) contacting a halogenated ethene with magnesium metal to obtain a halogenated ethene Grignard reagent, and carrying out a Grignard reaction between the halogenated ethene Grignard reagent and R-epichlorohydrin; b) adding sodium cyanide for carrying out a nucleophilic substitution reaction; c) adding alcohol for carrying out an alcoholysis reaction; d) adding a basic solvent for carrying out protection of a first hydroxyl group; e) selectively oxidizing a second hydroxyl group; and f) adding triphenylphosphine in alkaline condition for carrying out a Wittig reaction.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: January 13, 2015
    Assignee: Porton Fine Chemicals Ltd.
    Inventors: Wenqing Lin, Hongjie Zheng, Xiaobo Liu
  • Method for preparing rosuvastatin calcium intermediate
    Patent number: 8703944
    Abstract: A method for preparing a rosuvastatin calcium intermediate represented by formula I. The method includes: hydrolyzing an ester compound represented by formula II (in which, R represents C1-C5) in the presence of a metal compound to obtain a carboxylic acid compound represented by formula III; and reducing the carboxylic acid compound in the presence of a reductant.
    Type: Grant
    Filed: February 3, 2013
    Date of Patent: April 22, 2014
    Assignee: Porton Fine Chemicals Ltd.
    Inventors: Wenqing Lin, Hongjie Zheng, Peng Yang
  • METHOD FOR PREPARING ROSUVASTATIN CALCIUM INTERMEDIATE
    Publication number: 20130143908
    Abstract: A method for preparing a rosuvastatin calcium intermediate represented by formula I. The method includes: hydrolyzing an ester compound represented by formula II (in which, R represents C1-C5) in the presence of a metal compound to obtain a carboxylic acid compound represented by formula III; and reducing the carboxylic acid compound in the presence of a reductant.
    Type: Application
    Filed: February 3, 2013
    Publication date: June 6, 2013
    Applicant: PORTON FINE CHEMICALS LTD.
    Inventor: Porton Fine Chemicals Ltd.
  • ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME
    Publication number: 20120310000
    Abstract: A method for preparing a rosuvastatin calcium intermediate, including a) contacting a halogenated ethene with magnesium metal to obtain a halogenated ethene Grignard reagent, and carrying out a Grignard reaction between the halogenated ethene Grignard reagent and R-epichlorohydrin; b) adding sodium cyanide for carrying out a nucleophilic substitution reaction; c) adding alcohol for carrying out an alcoholysis reaction; d) adding a basic solvent for carrying out protection of a first hydroxyl group; e) selectively oxidizing a second hydroxyl group; and f) adding triphenylphosphine in alkaline condition for carrying out a Wittig reaction.
    Type: Application
    Filed: August 16, 2012
    Publication date: December 6, 2012
    Applicant: PORTON FINE CHEMICALS LTD.
    Inventors: Wenqing LIN, Hongjie ZHENG, Xiaobo LIU