Abstract: A transdermal delivery system for the modulated administration of drugs is described. The drug delivery device comprises a backing; a drug reservoir containing the drug, a plasticizer-type enhancer, a solvent-type enhancer, and optionally, a gelling agent; a non-rate-controlling membrane; and an adhesive layer containing a plasticizer-type enhancer. This drug delivery system is particularly useful for the administration of tolerance-inducing drugs, for example, vasodilators, such as isosorbide dinitrate.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
March 25, 1997
Assignee:
PP Holdings Inc.
Inventors:
Frank Kochinke, William R. Pfister, Jenny Louie, Dan Arenson