Patents Assigned to PRECISION NANOSYSTEMS INC.
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Publication number: 20220162552Abstract: There is provided a lipid mix composition comprising ionizable lipid, a structural lipid such as DSPC, a sterol, and a surfactant such as polysorbate 80, polyoxyethylene (10) stearyl ether, polyoxyethylene (20) stearyl ether, or D-?-Tocopherol polyethylene glycol 1000 succinate. The lipid mix compositions find particular use in transfecting difficult to transfect cells and maintaining the viability of those cells. The lipid mix compositions are particularly well suited to T cell transfection ex vivo.Type: ApplicationFiled: April 14, 2020Publication date: May 26, 2022Applicant: Precision NanoSystems Inc.Inventors: Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara Fernandez
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Publication number: 20210291179Abstract: A “smart ” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.Type: ApplicationFiled: June 7, 2021Publication date: September 23, 2021Applicant: Precision NanoSystems IncInventors: Andre Wild, Timothy Leaver, Robert James Taylor, Euan Ramsay, Nicolas Klaassen, Shao Fang Shannon Chang, Keara Marshall
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Publication number: 20210284998Abstract: A transfection reagent composition comprising: 30-60 MOL % of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL % structural lipid; a sterol and 0.1 to about 10 MOL % of a stabilizing agent is provided. The reagent is particularly adapted for neuron and related cell types. A method of manufacturing LNP including nucleic acid for selective uptake into either neurons or astrocytes or neural progenitor cells is also provided.Type: ApplicationFiled: October 2, 2017Publication date: September 16, 2021Applicant: Precision NanoSystems Inc.Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
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Patent number: 11059039Abstract: A “smart” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.Type: GrantFiled: June 30, 2017Date of Patent: July 13, 2021Assignee: Precision NanoSystems Inc.Inventors: Andre Wild, Timothy Leaver, Robert James Taylor, Euan Ramsay, Nicolas Klaassen, Shao Fang Shannon Chang, Keara Marshall
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Publication number: 20210162052Abstract: A reagent composition for delivery nucleic acid therapeutics to cells is provided. The reagent includes ionizable lipid, structural lipid, and a stabilizing agent which improves the transfection efficiency of nucleic acids, and leaves transfected cells viable. The 5 transfection reagent is effective in plasmid and mRNA delivery, and in neurons and progenitor-like cells. It may be used for ex vivo cell therapy.Type: ApplicationFiled: April 15, 2019Publication date: June 3, 2021Applicant: Precision NanoSystems Inc.Inventors: Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara L. Fernandez
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Publication number: 20200139321Abstract: The present invention provides a microfluidic mixing platform having a bulk, the platform including an inlet well, a microchannel, a passive capillary valve a mixing feature and an outlet. The passive capillary valve prevents unwanted capillary flow along the microchannel. The passive capillary valve comprises a widening of the microchannel relative to the direction of fluid flow, and the angle has a graduated profile. The mixing platform bulk comprises a rigid matrix capable of machine manufacture. A method of preventing backflow in a microfluidic mixer is also provided.Type: ApplicationFiled: January 17, 2018Publication date: May 7, 2020Applicant: Precision Nanosystems Inc.Inventors: Andre Wild, Shao Fang Shannon Chang, Timothy Leaver
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Publication number: 20200023358Abstract: A “smart” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.Type: ApplicationFiled: June 30, 2017Publication date: January 23, 2020Applicant: Precision Nanosystems Inc.Inventors: Andre Wild, Timothy Leaver, Robert James Taylor, Euan Ramsay, Nicolas Klaassen, Shao Fang Shannon Chang, Keara Marshall
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Publication number: 20190292566Abstract: A transfection reagent composition comprising: 30-60 MOL. % of a cationic lipid, or a pharmaceutical acceptable salt thereof; 10-60 MOL % of a structural lipid; 10-20 MOL % of a triglyceride; and 0.1 to about 10 MOL. % of a stabilizing agent, is provided. The transfection agent is effective in transfecting cells, particularly neurons, with siRNA, mRNA and plasmid nucleic acid, Sand maintaining viability of the cells as well as activity of the delivered nucleic acid.Type: ApplicationFiled: December 19, 2017Publication date: September 26, 2019Applicant: Precision NanoSystems Inc.Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
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Patent number: D800335Type: GrantFiled: July 13, 2016Date of Patent: October 17, 2017Assignee: PRECISION NANOSYSTEMS INC.Inventors: Shao Fang Shannon Chang, Andre Wild, Keara Marshall
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Patent number: D800336Type: GrantFiled: July 13, 2016Date of Patent: October 17, 2017Assignee: PRECISION NANOSYSTEMS INCInventors: Shao Fang Shannon Chang, Andre Wild, Sukhjinder Singh Sidhu, Ke Ma, Benjamin Albert Versteeg, Timothy Leaver
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Patent number: D812242Type: GrantFiled: July 13, 2016Date of Patent: March 6, 2018Assignee: PRECISION NANOSYSTEMS INCInventors: Shao Fang Shannon Chang, Andre Wild, Sukhjinder Singh Sidhu, Ke Ma, Benjamin Albert Versteeg, Timothy Leaver
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Patent number: D849265Type: GrantFiled: April 21, 2017Date of Patent: May 21, 2019Assignee: PRECISION NANOSYSTEMS INCInventors: Andre Wild, Timothy Leaver, Shao Fang Shannon Chang, Niklaus Alexander Andre, Rodney Paul Bucknell, Andrew Robert Patterson, Phillip Higgins, Thomas William Cameron Debenham
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Patent number: D878622Type: GrantFiled: April 7, 2018Date of Patent: March 17, 2020Assignee: Precision NanoSystems Inc.Inventors: Andre Wild, Rodney Paul Bucknell
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Patent number: D919110Type: GrantFiled: August 9, 2019Date of Patent: May 11, 2021Assignee: Precision NanoSystems Inc.Inventors: Benjamin Albert Versteeg, Keara Marshall
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Patent number: D951479Type: GrantFiled: June 24, 2019Date of Patent: May 10, 2022Assignee: PRECISION NANOSYSTEMS INC.Inventors: Benjamin Albert Versteeg, Robert Young