Patents Assigned to President and Felllows of Harvard College
  • Genetically stable cholera vaccines with deletions of ctxA, recA and attRS1
    Patent number: 5631010
    Abstract: The invention features a nontoxigenic genetically stable mutant strain of V. cholerae which lacks any functional attRS1 sequences is useful as a live, oral vaccine for inducing immunological protection against cholera and a method for making same. The invention also features a killed, oral cholera vaccine comprising at least a first and a second V. cholerae strain, wherein at least one of the strains is a different serotype, and the vaccine also contains cholera toxin B subunit, produced by at least one of the serotypes.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: May 20, 1997
    Assignee: President and Felllows of Harvard College
    Inventor: John J. Mekalanos