Abstract: The invention described herein relates to colloidal particles useful for photoacoustic imaging. The particles comprise a photoacoustic imaging agent with an absorbance maximum or plateau in the range of wavelengths 700-1100 nm. The imaging agent also displays low optical absorbance at some wavelength in the range 700-1100 nm. This combination of high and low optical absorbance enables background subtraction in photoacoustic imaging applications. The imaging agent is an organic compound having low aqueous solubility so that it is stably encapsulated in the hydrophobic core of the particle. The particle is stabilized by a polymeric surface coating, and the polymeric stabilizing layer on the surface of the particle may contain targeting ligands for targeted diagnostics or therapeutic delivery. The particle core may also contain therapeutic agents or other imaging agents.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms, apparatus, and improvements thereof for in-memory computing using charge-domain circuit operation to provide energy efficient, high speed, capacitor-based in-memory computing. Various embodiments contemplate controlling input signal presentation within in-memory computing structures/macros in accordance with predefined or dynamic switch selection criteria to reduce energy consumption associated with charging and/or discharging summing capacitors during reset and evaluation operating modes of multiplying bit-cells (M-BCs).

Abstract: A method for controllably making catalysts with at least one metallic surface state, that includes: a) identifying all the topological insulators in the ICSD, b) calculating the Real Space Invariants of the valence bands for all these topological insulators in order to c) identify in all these topological insulators the Wyckoff Positions where the irreducible Wannier Charge Centers (WCCs) are localized, and then d) selecting as potentially catalytic active compound a topological insulator in which the position of WCCs is not occupied by any atom; e) synthesizing a crystal of the selected potentially catalytic active compound either so that it is grown in a predefined crystallographic direction (characterized by its Miller indices (h,k,l)) which exposes the metallic surface state; or cutting the crystal in a predefined crystallographic direction (characterized by its Miller indices (h,k,l)), so that the metallic surface state is exposed when ( ( { ( h , k , l ) · ( x - X j , y -

Abstract: A method is provided for measuring different flow properties of a fluid. The method includes (a) providing a nanowire, the resistance of the nanowire varying based on temperature changes of the nanowire that reflect values of the different flow properties of the fluid when the nanowire is operated in different modes of operation respectively, such that the nanowire measures different flow properties when operated in different modes of operation respectively, and (b) alternating the nanowire between different modes of operation, measuring different flow properties of the fluid during the different modes of operation, respectively, and using the measurements of one of the flow properties to correct the measurements of another flow property. Other applications are also described.

Abstract: Disclosed is a technique for constructing optogenetic amplifier and inverter circuits utilizing transcriptional activator/repressor pairs, in which expression of the transcriptional activator or repressor, respectively, is controlled by light-controlled transcription factors. This system is demonstrated utilizing the quinic acid regulon system from Neurospora crassa, or Q System, a transcriptional activator/repressor system. This is also demonstrated utilizing the galactose regulon from Saccharomyces cerevisiae, or GAL System. Such optogenetic amplifier circuits enable multi-phase microbial fermentations, in which different light schedules are applied in each phase to dynamically control different metabolic pathways for the production of proteins, fuels or chemicals.

Abstract: Compositions that increase the bioavailability of dihydromyricetin are presented. The bioavailability is increased by methods including formulating dihydromyricetin in nanoparticle form, delivering dihydromyricetin with permeabilizers, and encapsulating dihydromyricetin with an enteric coating.

Abstract: Disclosed herein is a quantitative screen for the assessment of microbiome derived drug metabolism. The disclosed quantitative screen, named MDMQ-Screen, may be employed, inter alia, for assessing the impact of the human gut microbiome on drug metabolism. MDMQ-Screen is used to measure and explain inter-individual variability in drug metabolism. This information is crucial in explaining potential toxic effects of the administered drugs, as well variability in response to therapy between individuals. Inter alia, MDMQ-Screen can be used to assess unexplained variability in drug response and toxicity of already used medications; used in future drug development pipelines to aid in the design and interpretation of clinical trials; and used at bedside to assess the probability of drug response and toxicity and provide recommendations for therapeutic modifications in a personalized medicine manner.

Abstract: Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated.

Abstract: This disclosure provides a system and method for producing ultrasound images based on Full Waveform Inversion (FWI). The system captures acoustic/(an)elastic waves transmitted through and reflected and/or diffracted from a medium. The system performs an FWI process in a time domain in conjunction with an accurate wave propagation solver. The system produces 3D maps of physical parameters that control wave propagation, such as shear and compressional wavespeeds, mass density, attenuation, Poisson's ratio, bulk and shear moduli, impedance, and even the fourth-order elastic tensor containing up to 21 independent parameters, which are of significant diagnostic value, e.g., for medical imaging and non-destructive testing.

Abstract: Systems and methods are described, and one system includes a three-dimensional (3D) geometric tracker connected to a multiband (MB) inverse synthetic aperture array radar (ISAR), and a classification/alarm logic. The MB ISAR includes spatially distributed radar transmitters (TXs) and receivers (RXs), a TX/RX allocation logic, and a tomographic (TM) image logic. The TX/RX allocation logic is configured to receive 3D tracking data from the 3D geometric tracker, indicating subject 3D position and 3D orientation and, in response, dynamically allocate TXs and RXs to maintain MB illumination of and maintain MB reception of multiple scatter angles from subjects. The TM image processor is configured to construct TM images from the scatter angles, using 3D tracking data, for input to the classification and alarm logic. Optionally, the TX/RX resource allocation logic is configured to receive situation feedback data, for feedback adjusting of allocation of TXs and RXs.

Abstract: According to various embodiments, a machine-learning based system for coronavirus detection is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs and questionnaire data from a user interface. The processors are further configured to train at least one neural network based on raw physiological data and questionnaire data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one coronavirus inference model. The processors are also configured to output a coronavirus-based decision by inputting the received physiological data and questionnaire data into the generated coronavirus inference model.

Abstract: The present disclosure relates, in general, to a fusion protein construct comprising RNase L and a split reporter system, and methods of using the reporter for detecting 2?-5? linked oligoadenylates (2-5A) and double stranded RNA in vivo.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.

Abstract: Various embodiments comprise systems, methods, mechanisms, apparatus, and improvements thereof providing a machine learning based inverse design method for mm-wave/RF power amplifiers (PAs). Methods according to embodiments provide for efficiently synthesizing power amplifier matching circuit (output matching/output power combiner/backoff efficient output power combiner, interstage matching and input matching/input power divider and phase shifter) for a close to optimum solution in terms of matching bandwidth, efficiency and load modulation, which can exceed the performance limitations of traditional matching network designs.

Abstract: Methods for forming a coating over a surface are disclosed. A method includes directing a first source of barrier film material toward a substrate in a first direction at an angle ? relative to the substrate, wherein ? is greater than about 0° and less than about 85°. Additionally, a method of depositing a barrier film over a substrate includes directing a plurality of N sources of barrier film material toward a substrate, each source being directed at an angle ?N relative to the substrate, wherein for each ?N, ? is greater than about 0° and less than about 180°. For at least a first of the ?N, ?N is greater than about 0° and less than about 85°, and for at least a second of the ?N, ?N is greater than about 95° and less than about 180°.

Abstract: The microlens amplitude masks for flying pixel removal in time-of-flight imaging includes systems, devices, methods, and instructions for image depth determination, including receiving an image, adding noise to the image, determining a set of correlation images, each correlation image having a varying phase offset, for each pixel of the image, generating a masked pixel by applying a mask array, and for each masked pixel, determining the depth of the masked pixel to generate a depth map for the image on a per pixel basis.

Abstract: Disclosed herein is the detection of dangerous dielectric materials (explosives) and dangerous non-explosive and/or prohibited items. The detection is based on a broad bandwidth nonlinear radar system, driven by a highly stable optical frequency comb. The disclosed approach allows for the spatial resolution of the interrogated object in complex settings. Detection of dangerous materials and non-explosive chemical prohibited items is disclosed.

Abstract: Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective.

Abstract: According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes at least two vertically stacked printed circuit boards (PCBs) comprising a top PCB and a bottom PCB. The power converter circuit further includes at least one multiphase coupled inductor placed between the top PCB and the bottom PCB. The top PCB is coupled to the bottom PCB via at least one conductive winding of the multiphase coupled inductor. The power converter circuit further includes at least one circuit module placed above the top PCB and at least one power source placed below the bottom PCB. The multiphase coupled inductor is configured to deliver current vertically from the bottom PCB to the top PCB.

Abstract: An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.