Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
Type:
Application
Filed:
January 29, 2007
Publication date:
March 6, 2008
Applicant:
Pro-Virus, Inc.
Inventors:
Michael Roberts, Robert Lorence, William Groene, Harvey Rabin, Reid von Borstel
Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
Type:
Application
Filed:
June 13, 2002
Publication date:
September 4, 2003
Applicant:
Pro-Virus, inc.
Inventors:
Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
Type:
Application
Filed:
January 15, 2002
Publication date:
March 6, 2003
Applicant:
Pro-Virus, Inc.
Inventors:
Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
Abstract: Human fetal neuro-derived cell lines are implanted into host tissues. The methods allow for treatment of a variety of neurological disorders and other diseases. A preferred cell line is SVG.
Type:
Application
Filed:
October 10, 2001
Publication date:
August 15, 2002
Applicant:
Pro-Virus, Inc.
Inventors:
Eugene O. Major, Carlo S. Tornatore, Kris Bankiewicz