Abstract: Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
Type:
Application
Filed:
January 21, 2009
Publication date:
May 14, 2009
Applicant:
Progen Pharmaceuticals, Inc.
Inventors:
Benjamin Frydman, Linda Clifford, Aldonia L. Valasinas, Andrei V. Blokhin, Hirak S. Basu, Laurence J. Marton, Venodhar K. Reddy
Abstract: Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
Type:
Grant
Filed:
October 1, 2004
Date of Patent:
February 17, 2009
Assignee:
Progen Pharmaceuticals, Inc.
Inventors:
Linda Clifford, legal representative, Aldonia L. Valasinas, Andrei V. Blokhin, Hirak S. Basu, Laurence J. Marton, Venodhar K. Reddy, Benjamin Frydman
Abstract: Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
Type:
Grant
Filed:
June 4, 2007
Date of Patent:
November 18, 2008
Assignee:
Progen Pharmaceuticals, Inc.
Inventors:
Linda Clifford, legal representative, Aldonia L. Valasinas, Andrei V. Blokhin, Aparajita Sarkar, Hirak S. Basu, Venodhar K. Reddy, Laurence J. Marton, Yu Wang, Benjamin Frydman
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