Patents Assigned to Protein Discovery, Inc.
  • Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization(MALDI) mass spectrometry (MS)
    Patent number: 7534338
    Abstract: Analytical methods and devices are disclosed for separating low abundance analytes by electrophoretically driving the analytes through a sieving matrix to first remove high molecular weight species. Subsequently the remaining low abundance analytes are electrophoretically focused onto a capture membrane where the analytes become bound within a small capture site. After this step the capture membrane may be allowed to dry and then attached to a conductive MALDI sample plate.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: May 19, 2009
    Assignee: Protein Discovery, Inc.
    Inventors: Dean Hafeman, Kilian Dill, James B. Harkins, Richard M. Caprioli, Jeremy Norris, Nathan S. Lewis, Daniel Kuban, Charles E. Witkowski, II
  • Methods and Devices for Concentration and Fractionation of Analytes for Chemical Analysis Including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS)
    Publication number: 20090071834
    Abstract: A device is described for pre-concentration and purification of analytes from biological samples (such as human serum, plasma, homogenized solid tissue, etc.) to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.
    Type: Application
    Filed: June 9, 2008
    Publication date: March 19, 2009
    Applicant: PROTEIN DISCOVERY, INC.
    Inventors: Dean G. Hafeman, James B. Harkins, IV, Jeremy L. Norris, Sheila N. Baker, Donald R. Loveday, Daniel P. Kuban, Richard M. Caprioli, Charles E. Witkowski, II, Benjamin B. Katz, Salvadore J. Pastor
  • Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS)
    Publication number: 20050116161
    Abstract: Analytical methods and devices are disclosed for separating low abundance analytes by electrophoretically driving the analytes through a sieving matrix to first remove high molecular weight species. Subsequently the remaining low abundance analytes are electrophoretically focused onto a capture membrane where the analytes become bound within a small capture site. After this step the capture membrane may be allowed to dry and then attached to a conductive MALDI sample plate.
    Type: Application
    Filed: October 12, 2004
    Publication date: June 2, 2005
    Applicant: Protein Discovery, Inc.
    Inventors: Dean Hafeman, Kilian Dill, James Harkins, Richard Caprioli, Jeremy Norris, Nathan Lewis, Daniel Kuban, Charles Witkowski