Patents Assigned to Proteinix, Inc.
  • Controlling protein levels in eucaryotic organisms
    Patent number: 7074620
    Abstract: Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having a ubiquitination recognition element covalently linked to a target protein binding element. The ubiquitination and recognition element can bind to either the E3 or E2 elements of the ubiquitination system and the target protein binding element is able to bind specifically to the target protein. The target protein binding element has a molecular weight of less than 30,000 and has a binding affinity for the target protein greater than 105M31 1.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: July 11, 2006
    Assignee: Proteinix, Inc.
    Inventors: John H. Kenten, Steven F. Roberts
  • Controlling protein levels in eucaryotic organisms
    Publication number: 20030153727
    Abstract: The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.
    Type: Application
    Filed: January 16, 2003
    Publication date: August 14, 2003
    Applicant: Proteinix, Inc.
    Inventors: John H. Kenten, Steven F. Roberts
  • Controlling protein levels in eucaryotic organisms
    Patent number: 6559280
    Abstract: The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: May 6, 2003
    Assignee: Proteinix, Inc.
    Inventors: John H. Kenten, Steven F. Roberts
  • Controlling protein levels in eucaryotic organisms
    Publication number: 20020173049
    Abstract: The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.
    Type: Application
    Filed: June 14, 2001
    Publication date: November 21, 2002
    Applicant: Proteinix, Inc.
    Inventors: John H. Kenten, Steven F. Roberts
  • Controlling protein levels in eucaryotic organisms
    Publication number: 20020146843
    Abstract: The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.
    Type: Application
    Filed: June 14, 2001
    Publication date: October 10, 2002
    Applicant: Proteinix, Inc.
    Inventors: John H. Kenten, Steven F. Roberts