Patents Assigned to Proteus Molecular Design Limited
  • Fragments of prion proteins
    Publication number: 20030199013
    Abstract: Synthetic polypeptides having at least one antigenic site of a prior protein, methods for their use and manufacture, antibodies raised against such polypeptides and diagnostic kits containing these polypeptides or antibodies.
    Type: Application
    Filed: April 5, 2002
    Publication date: October 23, 2003
    Applicant: Proteus Molecular Design Limited
    Inventors: Robert Vincent Fishleigh, Barry Robson, Roger Paul Mee
  • Fragments of prion proteins
    Patent number: 6379905
    Abstract: Synthetic polypeptides having at least one antigenic site of a prion protein, methods for their use and manufacture, antibodies raised against such polypeptides and diagnostic kits containing these polypeptides or antibodies.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 30, 2002
    Assignee: Proteus Molecular Design Limited
    Inventors: Robert Vincent Fishleigh, Barry Robson, Roger Paul Mee
  • LHRH hormones
    Patent number: 5897863
    Abstract: An analogue of lutenising hormone-releasing hormone (LHRH) having the amino acid sequence: pGlg-His-Trp-Ser-Tyr-X-Len-Arg-Pro-Gly-Y-Zwherein X represents Gly or a D-amino acid, Y represents one or more amino acid residues, which may be the same or different, and Z represents Cys or Tyr, such that the solution conformation of said analogue is substantially similar to that of native LHRH. The analogues may be used to prepare vaccines for reducing fertility in mammals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 27, 1999
    Assignee: Proteus Molecular Design Limited
    Inventors: Barry Robson, Robert V. Fishleigh
  • Vaccines
    Patent number: 5876721
    Abstract: Vesicles comprising at least one non-ionic surfactant and at least one molecule having the ability to transport or facilitate the transport of fats, fatty acids and lipids across mucosal membranes. With entrapped antigen they can act as immunological adjuvants. Vaccines based therein are active orally as well as by conventional administration routes and are simulators of antibody production via the Th 1 T lymphocyte partway.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: March 2, 1999
    Assignees: Proteus Molecular Design Limited, The University of Strathclyde
    Inventors: James Alexander, James MacDonald Brewer
  • Fragments of prion proteins
    Patent number: 5773572
    Abstract: Synthetic polypeptides having at least one antigenic site of a prion protein are disclosed together methods for their use and manufacture and antibodies raised against such polypeptides. Diagnostic kits using the polypeptides and/or antibodies are also disclosed.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: June 30, 1998
    Assignee: Proteus Molecular Design Limited
    Inventors: Robert Vincent Fishleigh, Barry Robson, Roger Paul Mee
  • Vaccines containing non-ionic surfactant vesicles
    Patent number: 5679355
    Abstract: Non-ionic surfactant vesicles (NSIV) with entrapped antigen act as potent immunological adjuvants and can produce antibody titers of the same order of magnitude as those using Freund's Complete Adjuvant. The invention provides vaccines comprising such vesicles. Preferably non-ionic surfactants are glycerol esters particularly 1-monopalmitoyl glycerol. The vesicles may be administered by injection or via the mucosal route, oral administration being preferred.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: October 21, 1997
    Assignee: Proteus Molecular Design Limited
    Inventors: James Alexander, James MacDonald Brewer