Patents Assigned to QUADRAM INSTITUTE BIOSCIENCE
  • ENGINEERING GUT COMMENSAL BACTERIA TO EXPRESS HETEROLOGOUS PROTEINS IN THEIR OUTER MEMBRANE VESICLES (OMVS) FOR DELIVERY TO THE GI-TRACT
    Publication number: 20210268094
    Abstract: This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.
    Type: Application
    Filed: May 10, 2021
    Publication date: September 2, 2021
    Applicants: QUADRAM INSTITUTE BIOSCIENCE, UEA ENTERPRISES LIMITED
    Inventors: REGIS GABRIEL STENTZ, SIMON RICHARD CARDING
  • SIALIC ACID TRANSPORTER PROTEINS AS BIOMARKERS AND DRUG TARGETS
    Publication number: 20210254138
    Abstract: A method of identifying, monitoring and/or diagnosing mucosal bacterial presence or infection, said method including the step of detecting at least part of a sialic acid transporter protein encoded by Ruminococcus gnavus (R. gnavus) ATCC 29149 Nan cluster. In addition, a method of inhibition of the growth of bacterium, said method including the step of inhibition of a sialic acid transporter protein is included.
    Type: Application
    Filed: June 17, 2019
    Publication date: August 19, 2021
    Applicant: Quadram Institute Bioscience
    Inventors: Nathalie Juge, Andrew Bell, John Walshaw
  • Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (OMVs) for delivery to the GI-tract
    Patent number: 11000581
    Abstract: This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 11, 2021
    Assignees: QUADRAM INSTITUTE BIOSCIENCE, UEA ENTERPRISES LIMITED
    Inventors: Regis Gabriel Stentz, Simon Richard Carding