Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
Type:
Grant
Filed:
August 29, 2003
Date of Patent:
June 6, 2006
Assignee:
Quadrant Drug Delivery Ltd.
Inventors:
Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
Type:
Grant
Filed:
February 27, 2003
Date of Patent:
May 17, 2005
Assignee:
Quadrant Drug Delivery Ltd.
Inventors:
Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
Abstract: A method for the production of stabilized platelets, comprises the steps of: (i) pre-activating platelets, to induce the formation of microvesicles; (ii) contacting the pre-activated platelets with a carbohydrate, whereby the carbohydrate is incorporated into the platelets; and (iii) drying the thus-loaded platelets.
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
Type:
Grant
Filed:
October 25, 2002
Date of Patent:
November 2, 2004
Assignee:
Quadrant Drug Delivery Ltd.
Inventors:
Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair