Patents Assigned to Qualigen, Inc.
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Patent number: 11235295Abstract: A method of processing a sample in a receptacle comprising a plurality of chambers. Each of the chambers is connected to at least one other chamber by a portal and at least a first one of the chambers is formed of a flexible material. The method includes the steps of causing gas bubbles contained in the first chamber to accumulate in a portion of the first chamber, applying a compressive external force to the first chamber to cause some or all of the liquid contents of the first chamber to flow into an interconnected second chamber through a portal connecting the first and second chambers; and preventing the gas bubbles accumulated in a portion of the first chamber from flowing through the portal into the second chamber.Type: GrantFiled: December 27, 2018Date of Patent: February 1, 2022Assignees: GEN-PROBE INCORPORATED, QUALIGEN, INC.Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Publication number: 20210299156Abstract: A method of administering an anti-nucleolin agent to a patient by delivering the anti-nucleolin agent to the mouth, lungs, throat, nose and eyes of a patient to prevent COVID-19. Compositions for administering an anti-nucleolin agent comprising a container and a formulation including an anti-nucleolin agent. The anti-nucleolin agent may be administered via an inhaler, nasal spray or eye drop.Type: ApplicationFiled: March 29, 2021Publication date: September 30, 2021Applicant: Qualigen Inc.Inventors: Paula J. Bates, Kenneth E. Palmer, Wajdi Abdul-Ahad, Michael Poirier
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Patent number: 10744258Abstract: A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.Type: GrantFiled: March 6, 2018Date of Patent: August 18, 2020Assignee: Qualigen Inc.Inventor: Michael Poirier
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Patent number: 10744469Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: December 12, 2008Date of Patent: August 18, 2020Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 10688458Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: April 12, 2017Date of Patent: June 23, 2020Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 10650527Abstract: The inventive subject matter is directed to point-of-care analytical devices that accurately determine the volume of test samples using image analysis to improve the accuracy of test results performed on the sample. Most preferably, the image analysis is based on rate changes in optical saturation that parallels sample saturation in a porous structure containing the sample.Type: GrantFiled: September 4, 2015Date of Patent: May 12, 2020Assignee: Qualigen, Inc.Inventors: Michael Poirier, John Stephen Middleton, Suzanne Marie Poirier
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Publication number: 20190126219Abstract: A receptacle comprises opposed members, a plurality of chambers having perimeter walls defined by seals formed between the opposed members and portals interconnecting the chambers, and a rigid frame supporting the opposed members at their peripheral edges. The frame comprises a front frame portion and a rear frame portion, and the peripheral edges of the opposed members are retained between the front and rear frame portions. An inlet port extends between the front and rear frame portions and is in fluid communication with one of the chambers.Type: ApplicationFiled: December 27, 2018Publication date: May 2, 2019Applicants: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. BREIDENTHAL, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Publication number: 20190126220Abstract: A method of processing a sample in a receptacle comprising a plurality of chambers. Each of the chambers is connected to at least one other chamber by a portal and at least a first one of the chambers is formed of a flexible material.Type: ApplicationFiled: December 27, 2018Publication date: May 2, 2019Applicants: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. BREIDENTHAL, Richard S. LEE, Norman C. NELSON, Matthew J. SCOTT, Jason A. TAYLOR
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Patent number: 9903799Abstract: Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.Type: GrantFiled: April 20, 2017Date of Patent: February 27, 2018Assignee: Qualigen, Inc.Inventors: Michael Poirier, John Stephen Middleton, Suzanne Marie Poirier
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Publication number: 20170218431Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: ApplicationFiled: April 12, 2017Publication date: August 3, 2017Applicants: GEN-PROBE INCORPORATED, QUALIGEN, INC.Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 9664668Abstract: Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.Type: GrantFiled: May 3, 2012Date of Patent: May 30, 2017Assignee: QUALIGEN, INC.Inventors: Michael Poirier, John Stephen Middleton, Suzanne Marie Poirier
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Patent number: 9144419Abstract: Contemplated diagnostic test containers and methods include an adapter configured to sealingly receive and retain a positive displacement pipette tip to so form a fluid-tight seal for the container during at least part of the diagnostic test. Most preferably, the entire container is flexible and the container and adapter are single-use disposable and are usable with known commercially available positive displacement pipette tips.Type: GrantFiled: October 23, 2009Date of Patent: September 29, 2015Assignee: Qualigen, Inc.Inventors: Michael Scot Poirier, Andrew Moulds
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Publication number: 20150086970Abstract: Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.Type: ApplicationFiled: May 3, 2012Publication date: March 26, 2015Applicant: Qualigen, Inc.Inventor: Michael Poirier
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Patent number: 8765367Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: December 12, 2008Date of Patent: July 1, 2014Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 8735055Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: December 12, 2008Date of Patent: May 27, 2014Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 8491178Abstract: A receptacle having interconnected chambers arranged to permit multiple process steps to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.Type: GrantFiled: March 7, 2012Date of Patent: July 23, 2013Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: D830573Type: GrantFiled: May 30, 2017Date of Patent: October 9, 2018Assignee: Qualigen, Inc.Inventors: Michael Poirier, John Stephen Middleton, James Wallace Ballentine, Suzanne Marie Poirier
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Patent number: D865210Type: GrantFiled: May 30, 2017Date of Patent: October 29, 2019Assignee: Qualigen, Inc.Inventors: Michael Poirier, John Stephen Middleton, James Wallace Ballentine, Suzanne Marie Poirier
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Patent number: D952157Type: GrantFiled: June 19, 2020Date of Patent: May 17, 2022Assignee: Qualigen Inc.Inventor: Michael Poirier
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Patent number: D979073Type: GrantFiled: April 6, 2022Date of Patent: February 21, 2023Assignee: Qualigen Inc.Inventor: Michael Poirier