Abstract: The present invention relates to compositions and methods use in designing immunoassay controls. In various aspects, the invention provides synthetic peptides comprising the sequence CPRRPYIL (SEQ ID NO: 1) or an analog thereof; ELAGLGFAELQC (SEQ ID NO: 4) or an analog thereof; and CDWRKNIDAL (SEQ ID NO: 8) or an analog thereof; specific binding reagents that bind to a CPRRPYIL (SEQ ID NO: 1), ELAGLGFAELQC (SEQ ID NO: 4) or CDWRKNIDAL (SEQ ID NO: 8) peptide; methods of producing such reagents; and assays utilizing such reagents to provide assay controls signals that are unrelated to the measurement of the analyte or analytes of interest in that no reagents used in the analyte assay(s) contribute to the control signal.
Type:
Grant
Filed:
December 13, 2021
Date of Patent:
August 15, 2023
Assignee:
Quidel Cardiovascular Inc.
Inventors:
Jonathan Gary, Scott Rongey, James Powell
Abstract: The present invention relates to compositions and methods use in designing immunoassay controls. In various aspects, the invention provides synthetic peptides comprising the sequence CPRRPYIL or an analog thereof; ELAGLGFAELQC or an analog thereof; and CDWRKNIDAL or an analog thereof; specific binding reagents that bind to a CPRRPYIL, ELAGLGFAELQC or CDWRKNIDAL peptide; methods of producing such reagents; and assays utilizing such reagents to provide assay controls signals that are unrelated to the measurement of the analyte or analytes of interest in that no reagents used in the analyte assay(s) contribute to the control signal.
Type:
Grant
Filed:
March 7, 2017
Date of Patent:
February 1, 2022
Assignee:
Quidel Cardiovascular Inc.
Inventors:
Jonathan Gary, Scott Rongey, James Powell
Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.
Type:
Application
Filed:
March 17, 2017
Publication date:
April 25, 2019
Applicant:
Quidel Cardiovascular Inc.
Inventors:
Erik Mikael OLSSON, Austin DERFUS, Armando TOVAR, Justin DAVIDSON, Tuan DO, Paul CRIVELLI, Matthew WANG
Abstract: A combination of capillary forces and gas pressure is used to control the movement of liquid samples within a microfluidic device. A liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action partway along the capillary channel. As the liquid sample moves, a pressure of a gas acting upon a distal gas-liquid interface of the liquid sample increases by an amount sufficient to stop further movement of the liquid sample. To initiate further movement of the liquid sample, a pump connected to a distal portion of the capillary channel decreases the pressure of the gas acting upon the distal gas-liquid interface of the liquid sample by an amount sufficient to permit the liquid sample to move by capillary action further along the capillary channel of the microfluidic device.
Type:
Grant
Filed:
April 5, 2013
Date of Patent:
December 4, 2018
Assignee:
Quidel Cardiovascular Inc.
Inventors:
William Patrick Coffey, Paul Michael Crivelli, Austin Matthew Derfus, Tuan Hoang Do, Remus Anders Brix Haupt, Emily Parker, Gregory Reneff, Armando Raul Tovar