Abstract: A method for species-independent measurement of complement (C) activation in animals. The method comprises taking samples in the range of 3-100 microliter of anticoagulated blood, plasma or serum of an animal (specimen), mixing the specimen with a specificity converting protein matrix (SCM), mixing to the specimen/SCM mixture an activator of the C system (Act), incubating the specimen/SCM/Act mixture at a temperature between 36° C. to 38° C. for a time of 5-120 min and determining the production of one or more human proteins by ELISA or other analytical methods.
Abstract: Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.
Type:
Grant
Filed:
July 31, 2012
Date of Patent:
January 1, 2019
Assignee:
Quidel Corporation
Inventors:
Peter Yan-Guo Ren, Jason McClure, Kevin S. Richardson
Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
Type:
Grant
Filed:
November 20, 2013
Date of Patent:
June 19, 2018
Assignee:
Quidel Corporation
Inventors:
Franz Aberl, Marcus Scheibenzuber, Robert P. Sambursky, Robert W. VanDine, Jose S. Sambursky
Abstract: Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.
Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.
Type:
Grant
Filed:
October 30, 2015
Date of Patent:
October 24, 2017
Assignee:
Quidel Corporation
Inventors:
Paul Lambotte, Michael Cerrito, Cecille Ramirez
Abstract: A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample is described. Methods of using the device are also described.
Type:
Grant
Filed:
May 7, 2013
Date of Patent:
February 7, 2017
Assignees:
Quidel Corporation, Northwestern University
Inventors:
Ashley Danielle Cramer, Mark J. Fisher, Jacqueline R. Groves, David M. Kelso, Lawrence W. Markus, Zaheer Parpia, Kunal Sur, Tom Westberg
Abstract: A laminated, integrated, analyte assay device and methods of using the device are described. The assay device is useful as an inexpensive, disposable assay device for detecting the presence and/or amount of a particular analyte in a body fluid or other sample.
Abstract: A system comprised of an apparatus and a test device is described. The test device and the apparatus are designed to interact to determine the presence or absence of an analyte of interest in a sample placed on the test device.
Type:
Grant
Filed:
March 1, 2013
Date of Patent:
December 8, 2015
Assignee:
Quidel Corporation
Inventors:
Richard L. Egan, Michael Jon Hale, Jhobe Steadman
Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
December 8, 2015
Assignee:
Quidel Corporation
Inventors:
Paul Lambotte, Michael Cerrito, Cecille Ramirez
Abstract: The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress of disease and/or treatment regimens, therapeutics, vaccines, etc., and for assisting clinicians in making treatment decisions.
Type:
Grant
Filed:
September 9, 2011
Date of Patent:
March 24, 2015
Assignee:
Quidel Corporation
Inventors:
Yunsheng Li, Paul D. Olivo, Jaekyung Kim
Abstract: Methods, compositions and kits for detecting the complement Factor B cleavage product Ba in a biological sample are described. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of or ruling out pre-eclampsia in a pregnant human subject.
Type:
Grant
Filed:
February 18, 2014
Date of Patent:
December 16, 2014
Assignee:
Quidel Corporation
Inventors:
Nikol Lee De Forest, John Tamerius, Noah Nasser, Patrick Sexton
Abstract: The present disclosure is directed to PCR-based assays and compositions for use in molecular detection of viral, bacterial and parasitic infectious agents in body fluid or tissue samples, and in particular to multiplex assays, as well as to solid reagent compositions for use in such assays.
Abstract: A packaging system with a dual chamber configuration is described. The packaging system is comprised of a primary chamber and a secondary chamber, where the primary chamber and the secondary chamber are in or capable of being in fluidic communication by a channel. The secondary chamber has an upper layer and a lower layer, wherein the lower layer is of a material that opens in response to an applied force that the upper layer is able to withstand, whereupon a fluid, preferably a liquid, in the primary chamber can be dispensed from the packaging system. In one embodiment, the packaging system is integrated with a planar cartridge having one or more chambers for processing a sample for detection of an analyte.
Abstract: Methods, compositions and kits for detecting the complement Factor B cleavage product Ba in a biological sample are described. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of or ruling out pre-eclampsia in a pregnant human subject.
Type:
Application
Filed:
February 18, 2014
Publication date:
June 19, 2014
Applicant:
Quidel Corporation
Inventors:
NIKOL LEE DE FOREST, John Tamerius, Noah Nasser, Patrick Sexton
Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.
Type:
Grant
Filed:
March 5, 2010
Date of Patent:
May 13, 2014
Assignee:
Quidel Corporation
Inventors:
Paul Lambotte, Michael Cerrito, Cecille Ramirez
Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
Type:
Application
Filed:
October 14, 2013
Publication date:
May 1, 2014
Applicant:
QUIDEL CORPORATION
Inventors:
LEONARD KOHN, JIM BROWN, DAVID SCHOLL, YUNSHENG LI, GIORGIO NAPOLITANO
Abstract: Methods, compositions and kits for detecting the complement Factor B cleavage product Ba in a biological sample are described. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of or ruling out pre-eclampsia in a pregnant human subject.
Type:
Grant
Filed:
June 22, 2012
Date of Patent:
April 8, 2014
Assignee:
Quidel Corporation
Inventors:
Nikol Lee De Forest, John Tamerius, Noah Nasser, Patrick Sexton
Abstract: Devices for use in extracting an analyte of interest from a sample are described. In one embodiment, a device is comprised of a first plurality of chambers, where one or more chambers in the plurality of chambers has a deep end and a shallow end with a depth d1. A channel disposed between at least two adjacent chambers in the plurality of chambers has a depth greater than d1. The dimensions of the chamber and channel provide control of fluid movement in the device, particularly when introducing fluid into the device for its use and during use of the device.
Type:
Application
Filed:
August 21, 2013
Publication date:
February 27, 2014
Applicants:
Quidel Corporation, Northwestern University
Inventors:
David M. Kelso, Kunal Sur, Tom Westberg, Zaheer Parpia, Mark J. Fisher
Abstract: An analytical device for performing an assay to determine the presence or approximate quantity of at least one analyte in a liquid sample is described. The device is manufactured to include an integrated desiccant within at least a test strip of the device. Addition of an integrated desiccant within the device improves signal to noise ratio, eases the manufacturing process, and saves in cost of production of the device.
Abstract: A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample is described. Methods of using the device are also described.