Patents Assigned to Radboud University Nijmegen
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Publication number: 20220198651Abstract: An apparatus including processing circuitry configured to: acquire a plurality of sets of medical imaging data of a region of a subject, each set of data corresponding to a respective different measurement period; apply a filter to the plurality of medical imaging data sets to produce a plurality of filtered medical imaging data sets corresponding to the different measurement periods, wherein the applying of the filter is such that, for each of the medical imaging data sets, the filtering uses at least some information from the other medical imaging data sets acquired at the different time periods and wherein the applying of the filter comprises applying at least one constraint or condition and the constraint or condition comprises preserving at least one measure of intensity for each medical imaging data set.Type: ApplicationFiled: December 21, 2020Publication date: June 23, 2022Applicants: Radboud University Nijmegen, CANON MEDICAL SYSTEMS CORPORATIONInventors: Mathias PROKOP, Brian MOHR, Paul THOMSON, Ewan HEMINGWAY
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Patent number: 10485860Abstract: The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention.Type: GrantFiled: November 17, 2016Date of Patent: November 26, 2019Assignee: Stichting Katholieke Universiteit / Radboud University Nijmegen Medical CentreInventors: Hester Jeanette Bootsma, Pieter Jan Burghout, Peter Wilhelmus Maria Hermans, Johanna Jacoba Elisabeth Bijlsma, Oscar Paul Kuipers, Tomas Gerrit Kloosterman
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Patent number: 10350298Abstract: The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example, for immunotherapy, such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.Type: GrantFiled: July 7, 2011Date of Patent: July 16, 2019Assignees: Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre, Stichting Katholieke Universiteit, meer in het bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Carl Gustav Figdor
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Patent number: 8338473Abstract: Derivatives of psammaplin A responding to formula (I), a method for their synthesis and their use for the preparation of a medicament for preventing and for treating a tumor or a cancer. Formula (I).Type: GrantFiled: February 28, 2008Date of Patent: December 25, 2012Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg, Institut National de la Sante et de la Recherche Medicale (Inserm), Universidade de Vito, Seconda Universita Degli Studi di Napoli, Radboud University NijmegenInventors: Hinrich Gronemeyer, Lucia Altucci, Angel De Lera, Hendrik Gerard Stunnenberg
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Publication number: 20120076827Abstract: The invention relates to a method for providing an activated antigen-presenting cell or a composition that comprises at least one activated antigen-presenting cell, which method at last comprises the steps of providing a composition that comprises at least one antigen-presenting cell and contacting said composition with a vaccine. Suitably, the at least one dendritic cell is brought into a state in which it is capable of stimulating T-cells and/or a T-cell mediated response.Type: ApplicationFiled: January 22, 2010Publication date: March 29, 2012Applicant: Stichting Katholieke Universiteit Radboud University Nijmegen Medical CentreInventors: Ingrid Jolanda Monique de Vries, Carl Gustav Figdor, Daniel Benitez Ribas
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Patent number: 7535223Abstract: In a method and apparatus for detection and spectral editing in MR spectroscopy by polarization transfer in which the high spin population difference of two or more energy levels of a particular nuclear spin system is transferred to the energy levels of an other nuclear spin system with lower spin population difference, all RF pulses to be irradiated are irradiated sequentially, i.e. with defined time interval to each other, so that at no time of the sequence are different RF pulses irradiated concurrently in an overlapping manner. The sequential succession of the RF pulses causes the polarization transfer between the two spin systems of atomic nuclei involved. The sequence of the RF pulses in each domain of the respective nuclei is completely symmetric.Type: GrantFiled: April 10, 2007Date of Patent: May 19, 2009Assignee: Radboud University Nijmegen Medical CentreInventors: Dennis Klomp, Arend Heerschap, Arno Kentgens
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Publication number: 20090099447Abstract: The invention is related to a method for generating hardness and/or strain information of a tissue which can be subject to a varying pressure, the method comprising: —positioning at least one signal transmitter (1) outside the tissue (10); —positioning at least one signal receiver (1) outside the tissue (10); —using the signal transmitter (1) to send signals (S) at different angles towards the tissue; —using the signal receiver (1) to receive signals from the tissue (10), wherein the received signals result from the signals that have been sent by said signal transmitter. The invention is also related to an apparatus for carrying out the method.Type: ApplicationFiled: August 18, 2006Publication date: April 16, 2009Applicant: Stichting Katholieke Universiteit, more particular The Radboud university Nijmegen Medical CenterInventor: Christoffel Leendert De Korte
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Patent number: 6573090Abstract: The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one embodiment, the packaging vector comprises a bacterial artificial chromosome (BAC) containing the HSV-1 genome. The packaging vector contains an intact pac site but is otherwise rendered packaging defective. The packaging vector can be rendered packaging defective by inserting nucleotides into the pac site, or by otherwise interfering with the capsid's ability to close, for example, by increasing the size of the DNA fragment upon which the herpes virus genome is cloned. This system can be used to package a wide range of nucleotide sequences (e.g., a therapeutic or antigenic gene) into an empty herpes virus particle taking advantage of the large transgene capacity of herpes viruses. This system can also be used as a vaccine to induce protective immunity against HSV-1, or other complex pathogens.Type: GrantFiled: December 9, 1999Date of Patent: June 3, 2003Assignees: The General Hospital Corporation, University Medical Centre St. Radboud of the University of Nijmegen, University of Zurich, The Walter & Eliza Hall Institute of Medical ResearchInventors: Xandra O. Breakefield, E. Antonio Chiocca, Yoshinaga Saeki, Cornel Fraefel, Kurt Tobler, Mathias Ackermann, Mark Suter, Gosse J. Adema, Ken Shortman