Abstract: A method for sealing a hole in a bodily organ includes introducing a first member and a second member into the bodily organ, the first and second members being connected by an elongated member. The first and second members are retracted proximally until the first member abuts an inner surface of the bodily organ and the second member is retracted out of the hole in the bodily organ. Then, the second member is pushed distally into abutment with an outer surface of the bodily organ. A sealing device for sealing a puncture in tissue is also described.

Abstract: The present invention provides a dissolvable medical sealing device (3, 4; 6, 7; 9) for closing a wound in vessel. A sealing device (3, 4, 6, 7, 9) according to the invention is made of a material that dissolves by means of physical processes, rather than by means of chemical or biological processes. Such a sealing device (3, 4; 6, 7; 9) can be made of polyethylene glycol, polypropylene glycol, copolymers containing ethylene glycol and propylene glycol, polyvinyl alcohol or polyvinyl pyrolidone, or any combinations thereof.

Abstract: The invention provides a method for replacing a first introducer, whose distal end is inside a vessel and whose proximal end is outside the skin of a patient, with a second introducer. The method comprises the steps of inserting a guide rod into the first introducer, removing the first introducer, passing the second introducer over the guide rod, and removing the guide rod. The guide rod to be used according to the method has preferably a flexible distal portion with a blunt distal end and a stiff proximal portion with a tapered proximal end.

Abstract: The invention relates to a method and a system for determining the blood flow in an individual coronary artery of a patient, wherein the method comprises the steps of positioning a temperature sensor mounted at a distal portion of a guide wire at a distal position in the coronary artery, positioning an infusion catheter in the coronary artery such that the distal end of the infusion catheter is proximally of the temperature sensor, measuring the blood temperature with the temperature sensor, infusing cold indicator fluid with a known infusion rate and known or measurable temperature into the coronary artery by the infusion catheter, measuring the temperature of the mixture of blood and indicator fluid by the temperature sensor, and calculating the coronary blood flow by a formula based on the known and measured quantities. In an extended version, the method comprises steps for relating the calculated coronary flow value to related normal flow values, or related FFR values, or a related flow resistance.

Abstract: Insertion tool for a medical closure device for the sealing of an opening in a wall of a bodily organ, comprising a tamping force source adapted to deliver a first member to a position at the opening on one side of the wall subsequently to a second member being positioned at the opening on the opposite side of the wall. The tamping force source, which is energized prior to the tamping procedure, can be for example a spring, an elastic band or a pressurized gas container. A tamping spring can be compressed or extended upon loading. The tamping force source can be released in response to a manual operation or be triggered by retraction of the insertion tool.

Abstract: A pressure sensor wire assembly measures pressure inside a body of a patient. The assembly comprises a pressure sensor element for measuring pressure and to generate a pressure sensor signal representative of the pressure, and a pressure sensor wire having the pressure sensor element at its distal portion, and adapted to be inserted into the body in order to position the sensor element within the body. A sensor signal adapting circuitry is an integrated part of the assembly, wherein the pressure sensor signal is applied to the adapting circuitry which is adapted to automatically generate an output pressure signal, related to the sensor signal, in a standardized format such that the measured pressure is retrievable by an external physiology monitor. The assembly further comprises an external pressure sensor to measure the pressure outside the patient's body and to generate external pressure values in dependence thereto.

Abstract: The present invention relates to a measuring device, insertable into a living body. The device includes an elongated flexible member in the form of a thick-walled hollow tube with a proximal end and a distal end. The tube defines a central lumen with an inner wall. The lumen may contain a core and an insulating material provided between the core and the inner wall. The core may be made of an electrically conductive material and may be of essentially constant diameter over its entire length. Alternatively, the lumen may contain at least two electrical leads. An electrical sensor is attached to the distal end of the elongated flexible member and is electrically connected to the core.

Abstract: A closure device includes an actuator movable between an initial extended position, a first position, and a second position with respect to a housing of the closure device, an inner seal configured to deploy from a distal end of the closure device when the actuator shifts from the initial extended position to the first position, a biasing mechanism configured to urge the actuator from the first position to the second position when a first pulling force is applied to the housing, and a locking member configured to deploy from the distal end of the closure device when the actuator shifts from the second position to the first position subsequent to deployment of the inner seal.

Abstract: An elongated introducer access assembly 2 comprising a distal end 4 and a proximal end 6, and provided with a first tubular channel 8 having a longitudinal axis 10 and running from a first proximal end opening 12 to a distal end opening (14) of the assembly and being adapted to receive a first tubular medical device. The assembly is provided with a second tubular channel 16 having a second proximal end opening 18 and running from the proximal end of the assembly. The second tubular channel being arranged in an angled direction in relation to the longitudinal axis of the first tubular channel, and that the second tubular channel enters the first tubular channel at a junction (20) proximally to the distal end of the assembly, and that an intersectional angle (?) is formed between the first tubular channel and the second tubular channel.

Abstract: A guide wire assembly includes a proximal end portion, a distal portion comprising a coil, a hollow stranded wire extending towards the distal portion, and a core wire. The guide wire assembly is characterized in that a proximal tube is provided, which extends from the proximal end portion to a proximal end of the hollow stranded wire such that the hollow stranded wire is directly joined to the proximal tube. The core wire extends into the distal portion and does not extend into the proximal tube. An entire length of the hollow stranded wire is in a range of 7.5 to 22.5% of an entire length of the guide wire assembly.

Abstract: A device having an inner seal and a retaining assembly seals a puncture in a blood vessel. The inner seal is placed inside the blood vessel and seals the puncture by contacting the inner surface wall of the blood vessel. The retaining assembly has at least two loops which engage the inner seal. Each loop may remain in substantial contact with the inner seal for substantially 360 degrees of the travel of each loop. The at least two loops may lie in a plane which is parallel to both the major axis of the inner seal and a folding axis. A locking member may be slid along the retaining assembly so as to contact the outer surface wall of the blood vessel.

Abstract: The invention provides an introducer sheath (1, 21, 51), whose distal end is to be positioned inside a vessel (10, 32, 62), at a predetermined distance from the wall (9, 31, 61) of the vessel (10, 32, 62). The introducer sheath (1, 21, 51) comprises a distal portion (2, 22, 52) with a first diameter and a proximal portion (3, 23, 53) with a second diameter, the first diameter being smaller than the diameter of the puncture hole and the second diameter being larger than the diameter of the puncture hole.

Abstract: During use there is a risk that a male connector for a guide wire is bent. With the present male connector (1) more material with high modulus of elasticity can be provided inside the male connector (1), which makes the male connector (1) more bending resistant. The male connector (1) comprises a core wire (3), a plurality of conductive members (4) spaced apart longitudinally along said core wire (3), a plurality of conductors (5) disposed along the core wire (3), each of the conductors (5) being connected to a respective conductive member (4). The core wire (3) has such a shape that least one longitudinal cavity is provided, which longitudinal cavity remains substantially intact when the male connector (1) is bent, thereby protecting the conductors (5), which are disposed in said cavity, from being damaged.

Abstract: The invention provides a closure device (1) for sealing an incision channel leading through a vessel wall and into the vessel. The closure device (1) comprises a haemostatic material (3), which is contained in the distal end of an elongated insertion assembly (2). The insertion assembly (2), which comprises a stationary part (4) and a retractable part (5) being slidably movable with regard to each other, is adapted to be attached to an introducer (7) being in position in the incision channel, so that the insertion assembly (2) can be slid along the introducer (7) until the distal end of the insertion assembly (2) is in contact with the vessel wall, where the haemostatic material (3) is delivered in the incision channel by a retracting movement of the retractable part (5).

Abstract: A device to seal an incision in a blood vessel includes an inner member and an outer member. A suture connects the inner member and the outer member. A first portion of the suture is embedded within a second portion of the suture such that as tension in the suture increases the first and second portions are held together.

Abstract: A pressure sensor wire assembly measures pressure inside a body of a patient. The assembly comprises a pressure sensor element for measuring pressure and to generate a pressure sensor signal representative of the pressure, and a pressure sensor wire having the pressure sensor element at its distal portion, and adapted to be inserted into the body in order to position the sensor element within the body. A sensor signal adapting circuitry is an integrated part of the assembly, wherein the pressure sensor signal is applied to the adapting circuitry which is adapted to automatically generate an output pressure signal, related to the sensor signal, in a standardized format such that the measured pressure is retrievable by an external physiology monitor. The assembly further comprises an external pressure sensor to measure the pressure outside the patient's body and to generate external pressure values in dependence thereto.

Abstract: Sensor wire assembly for measuring a physiological variable in a body, said assembly comprises a sensor element for measuring the physiological variable and to generate a sensor signal in response of said variable, and a guide wire having said sensor element at its distal end, and adapted to be inserted into the body in order to position the sensor element within the body. The assembly further comprises a sensor signal adapting circuitry, being an integrated part of said assembly, wherein the sensor signal is applied to the adapting circuitry that is adapted to automatically generate an output signal, related to the sensor signal, in a standardized format such that the measured physiological variable is retrievable by an external physiology monitor.

Abstract: A closure device for sealing a percutaneous puncture in the wall of a blood vessel includes: an insertion tool having an actuator which is operable in a first mode in which the actuator is configured for deployment of an inner seal inside the vessel and operable in a second mode in which the actuator is configured for tamping a locking member on an outside of the vessel, where the actuator is arranged to be set into the second mode in response to a pulling force acting on a filament connecting the inner seal and the locking member.

Abstract: During use there is a risk that a male connector for a guide wire is bent. With the present male connector (1) more material with high modulus of elasticity can be provided inside the male connector (1), which makes the male connector (1) more bending resistant. The male connector (1) comprises a core wire (3), a plurality of conductive members (4) spaced apart longitudinally along said core wire (3), a plurality of conductors (5) disposed along the core wire (3), each of the conductors (5) being connected to a respective conductive member (4). The connector (1) has such a configuration that the conductors (5) are protected from damage at the location where the conductors (5) connect to the conductive members (4).

Abstract: A tool (101) is provided for inserting and mating two plug members (2, 3) of a sealing device (1) for closing a wound in the wall of a vessel by placing the distal plug member (2) of the sealing device inside the vessel and the proximal plug member (3) on the outside of the vessel. The distal plug member is provided with an elongated retracting means (6) extending from the distal plug member. The tool comprises a gear mechanism (32) coupled to the retracting means for converting a movement of the tool in a proximal direction away from the wound (22), when the distal plug member is anchored in the vessel (20), to a pushing movement for moving the proximal plug member in a direction towards the distal plug member in response to a stretching force in the retracting means.