Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.
Type:
Grant
Filed:
March 14, 2022
Date of Patent:
March 5, 2024
Assignee:
RAPT Therapeutics, Inc.
Inventors:
Cyril Bucher, Adrian Dukes, Blanca Gomez, Hannah Haley, Dennis Hu, Jeffrey J. Jackson, Michelle Yoo Min Ko, Paul Leger, Anqi Ma, Andrew A. Ng, Daniel Poon, Omar Robles, Anton Shakhmin, Grant Shibuya, Parcharee Tivitmahaisoon, Vi-Anh Vu, David J. Wustrow, Mikhail Zibinsky
Abstract: Disclosed herein are therapeutic methods of administering compounds that modulate the C—C chemokine receptor type 4 (CCR4) for the treatment of Epstein Bar virus (EBV) positive cancers and malignancies.
Type:
Grant
Filed:
November 5, 2018
Date of Patent:
August 22, 2023
Assignee:
RAPT Therapeutics, Inc.
Inventors:
Gene Cutler, William Yew-Wai Ho, Paul David Kassner, Silpa Suthram, Brian Russell Wong
Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
Type:
Grant
Filed:
April 27, 2020
Date of Patent:
July 12, 2022
Assignee:
RAPT Therapeutics, Inc.
Inventors:
Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
Type:
Grant
Filed:
April 27, 2020
Date of Patent:
December 7, 2021
Assignee:
RAPT THERAPEUTICS, INC.
Inventors:
Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
Type:
Grant
Filed:
September 20, 2019
Date of Patent:
August 10, 2021
Assignee:
RAPT THERAPEUTICS, INC.
Inventors:
Berenger Biannic, Xinping Han, Dennis X. Hu, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, David Juergen Wustrow, Kyle Young, Gene Cutler, Yamini Ohol-Gupta
Abstract: Disclosed herein are pyrozolo-pyrimidin-amino-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.
Type:
Grant
Filed:
June 4, 2019
Date of Patent:
June 29, 2021
Assignee:
RAPT THERAPEUTICS, INC.
Inventors:
Minna H. T. Bui, Adrian O. Dukes, Xinping Han, Dennis X. Hu, Jeffrey J. Jackson, Yoo Min Ko, Paul R. Leger, Anqi Ma, Jack Maung, Andrew A. Ng, Akinori Okano, Omar Robles, Grant Shibuya, Hunter P. Shunatona, Jacob B. Schwarz, Anton A. Shakhmin, David J. Wustrow, Mikhail Zibinsky
Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
Type:
Grant
Filed:
November 13, 2018
Date of Patent:
July 28, 2020
Assignee:
RAPT THERAPEUTICS, INC.
Inventors:
Berenger Biannic, Xinping Han, Dennis X. Hu, John Michael Ketcham, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, Grant Shibuya, David Juergen Wustrow, Kyle Young
Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
Type:
Grant
Filed:
January 24, 2019
Date of Patent:
June 16, 2020
Assignee:
RAPT THERAPEUTICS, INC.
Inventors:
Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.
Type:
Grant
Filed:
November 19, 2018
Date of Patent:
March 31, 2020
Assignee:
RAPT THERAPEUTICS, INC.
Inventors:
Hilary Plake Beck, Berenger Biannic, Minna Hue Thanh Bui, Dennis X. Hu, John Michael Ketcham, Jay Patrick Powers, Maureen Kay Reilly, Omar Robles-Resendiz, Hunter Paul Shunatona, James Ross Walker, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky, Jeffrey J. Jackson