Patents Assigned to RECOMBINETICS, INC.
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Patent number: 11477969Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: GrantFiled: September 20, 2018Date of Patent: October 25, 2022Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10959414Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: GrantFiled: November 2, 2017Date of Patent: March 30, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10959415Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: GrantFiled: September 11, 2019Date of Patent: March 30, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10920242Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: GrantFiled: May 28, 2019Date of Patent: February 16, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10893667Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: GrantFiled: September 11, 2019Date of Patent: January 19, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20190254266Abstract: Human or humanized tissues and organs suitable for transplant are disclosed herein. Gene editing of a host animal provides a niche for complementation of the missing genetic information by donor stem cells. Editing of a host genome to knock out or debilitate genes responsible for the growth and/or differentiation of a target organ and injecting that animal at an embryo stage with donor stem cells to complement the missing genetic information for the growth and development of the organ. The result is a chimeric animal in which the complemented tissue (human/humanized organ) matches the genotype and phenotype of the donor. Such organs may be made in a single generation and the stem cell may be taken or generated from the patient's own body. As disclosed herein, it is possible to do so by simultaneously editing multiple genes in a cell or embryo creating a “niche” for the complemented tissue.Type: ApplicationFiled: October 27, 2016Publication date: August 22, 2019Applicants: Regents of the University of Minnesota, Recombinetics, Inc., Board of Regents of the University of Texas SystemInventors: Scott C. Fahrenkrug, Daniel F. Carlson, Peter Igarashi, Thomas Carroll
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Patent number: 10058078Abstract: A genetically modified livestock animal comprising a genomic modification to an eIF4G gene. Cells, genes, and proteins encompassing a protease-resistant eIF4G protein or gene.Type: GrantFiled: March 15, 2013Date of Patent: August 28, 2018Assignee: RECOMBINETICS, INC.Inventors: Daniel F. Carlson, Scott C. Fahrenkrug
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Patent number: 9528124Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: GrantFiled: April 28, 2014Date of Patent: December 27, 2016Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 9499808Abstract: Transgenic pigs that express one or more non-porcine cytosine deaminases are described as well as methods of making and using such pigs.Type: GrantFiled: November 20, 2009Date of Patent: November 22, 2016Assignee: Recombinetics, Inc.Inventors: Reuben S. Harris, Stefan R. Jonsson, Scott C. Fahrenkrug, Rebecca St. Claire Larue
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Patent number: 9074224Abstract: Disclosed herein are methods and compositions for gene targeting utilizing fusion molecules comprising a recombinase domain and a sequence-specific DNA-binding domain.Type: GrantFiled: August 26, 2010Date of Patent: July 7, 2015Assignee: Recombinetics, Inc.Inventors: Jeffrey J. Essner, Hsin-Kai Liao, Scott C. Fahrenkrug
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Publication number: 20140338007Abstract: Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.Type: ApplicationFiled: July 14, 2014Publication date: November 13, 2014Applicant: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson, Aron M. Geurts
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Patent number: 8785718Abstract: Methods of using hypermethylated transposons to create genetically modified animals that express interfering RNAs are described.Type: GrantFiled: October 5, 2012Date of Patent: July 22, 2014Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson, Aron M. Geurts
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Publication number: 20140201857Abstract: Compositions and methods for making livestock with a polled allele are presented, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.Type: ApplicationFiled: January 14, 2014Publication date: July 17, 2014Applicant: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 8518701Abstract: Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.Type: GrantFiled: May 9, 2012Date of Patent: August 27, 2013Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20130090522Abstract: Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.Type: ApplicationFiled: October 5, 2012Publication date: April 11, 2013Applicant: RECOMBINETICS, INC.Inventor: RECOMBINETICS, INC.