Abstract: The present invention provides compositions and methods for treating or preventing bacterial infections. Also provide by the invention are genetically modified cell expressing Lewisb carbohydrate epitope.
Type:
Grant
Filed:
October 14, 2005
Date of Patent:
February 9, 2010
Assignee:
Recopharma AB
Inventors:
Jan Holgersson, Jining Liu, Anki Gustafsson, Jonas Lofling
Abstract: The present invention relates to an antigenic fusionprotein, which carries multiple Gal?1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of a hyperacute rejection reaction in a patient who is to receive a xenotransplant.