Abstract: An object of the present invention is to provide a process for conveniently and efficiently producing high purity thioredoxin from yeast. In the production of thioredoxin using yeast, thioredoxin is produced through the following steps (i) to (iii): (1) culturing the yeast; (2) stressing the yeast obtained in step (1) to cause a release of thioredoxin from a cell of the yeast; and (3) collecting the thioredoxin released from the yeast cell.

Abstract: Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF.

Abstract: [Problems] To provide a novel protease inhibitor and curative remedies and a therapeutic method for chronic obstructive pulmonary disease, immunodeficiency syndrome, alveolar proteinosis and circulatory diseases. [Means for Solving Problems] A protease inhibitor and a preventive or a remedy for chronic obstructive pulmonary disease or immunodeficiency syndrome characterized by containing at least one member selected from among redox active proteins and genes encoding the same and a preventive or a remedy for chronic obstructive pulmonary disease, alveolar proteinosis or circulatory diseases characterized by containing at least one member selected from IL-18 and a gene encoding the same.

Abstract: Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF.

Abstract: [Problems] The present invention aims to provide a preventive or therapeutic agent for inflammatory ocular-surface diseases. [Means for Solving Problems] The present invention provides a preventive or therapeutic agent for inflammatory ocular-surface diseases, which comprises polypeptides of thioredoxin superfamily as an active ingredient.

Abstract: An object of the present invention is to provide a process for conveniently and efficiently producing high purity thioredoxin from yeast. In the production of thioredoxin using yeast, thioredoxin is produced through the following steps (i) to (iii): (1) culturing the yeast; (2) stressing the yeast obtained in step (1) to cause a release of thioredoxin from a cell of the yeast; and (3) collecting the thioredoxin released from the yeast cell.

Abstract: The object of the invention is to provide animal model of disorder and method of screening an agent for preventing or treating Metabolic Syndrome by using the animal model, wherein said animal model is used as experimental material which is essential to detailed analysis of component and pathologic condition of Metabolic Syndrome and to development of the method for treating and the agent for preventing and treating the Metabolic Syndrome. The above object is achieved by the non-human mammal model of disorders, whose TBP-2 gene is functionally deficient on chromosome, wherein the disorders are caused by impaired fatty acid utilization, and a method of screening an agent for preventing or treating Metabolic syndrome comprising; administering a test article to the non-human mammal whose TBP-2 gene is functionally deficient on chromosome.

Abstract: The object of the invention is to provide animal model of disorder and method of screening an agent for preventing or treating Metabolic Syndrome by using the animal model, wherein said animal model is used as experimental material which is essential to detailed analysis of component and pathologic condition of Metabolic Syndrome and to development of the method for treating and the agent for preventing and treating the Metabolic Syndrome. The above object is achieved by the non-human mammal model of disorders, whose TBP-2 gene is functionally deficient on chromosome, wherein the disorders are caused by impaired fatty acid utilization, and a method of screening an agent for preventing or treating Metabolic syndrome comprising; administering a test article to the non-human mammal whose TBP-2 gene is functionally deficient on chromosome.

Abstract: The present invention provides a therapeutic agent for treating inflammatory bowel diseases comprising as an active ingredient at least one member selected from polypeptides belonging a family exhibiting thioredoxin activity.

Abstract: Preventive or therapeutic agents for controlling various disorders induced by toxic substances in smoke produced by the combustion of fibers such as tobacco are disclosed. A polypeptide of the thioredoxin family (TRX) prevents toxic substances in smoke, produced by the combustion of fibers such as tobacco, from inducing inflammatory reactions and tissue fibrosis. Accordingly, TRX is effective for controlling of a wide range of disorders caused by toxic substances contained in smoke produced by combustion of fibers. The object of the present invention is to provide the preventive or therapeutic agents for disorders caused by toxic substances contained in smoke produced by combustion of fibers comprising an effective amount of polypeptide of thioredoxin family and/or one or more of its inducers.