Patents Assigned to REDX Pharma Limited
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Patent number: 9102656Abstract: This invention relates to the discovery of novel rosuvastatin analogs. More specifically, the invention relates to novel rosuvastatin analogs which have utility in treating conditions treatable by the inhibition of HMG-CoA reductase.Type: GrantFiled: September 17, 2013Date of Patent: August 11, 2015Assignee: RedX Pharma LimitedInventors: Derek Lindsay, Peter Jackson
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Patent number: 9024025Abstract: Provided are a compound of formula (5) and a process for its preparation wherein: R1 represents an alkyl group; R2 represents an aryl group; R3 represents a protecting group or an alkyl group; R4 represents a protecting group or a SO2R5 group where R5 is an alkyl group; R6 represents (PR7R8)+X? or P(?O)R7R8 in which X is an anion and R7 and R8 each independently is an alkyl, aryl, alkoxy, or aryloxy group; P1 represents hydrogen or a protecting group; and W represents ?O or OP2, in which P2 represents hydrogen or a protecting group.Type: GrantFiled: March 25, 2014Date of Patent: May 5, 2015Assignee: Redx Pharma LimitedInventors: David J. Moody, Jonathan W. Wiffen
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Patent number: 9006282Abstract: This invention relates to the discovery of novel rosuvastatin and atorvastatin analogues.Type: GrantFiled: July 17, 2013Date of Patent: April 14, 2015Assignee: Redx Pharma LimitedInventors: Derek Lindsay, Peter Jackson, Stephen Hindley, Inder Bhamra
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Patent number: 8946224Abstract: The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state.Type: GrantFiled: November 11, 2011Date of Patent: February 3, 2015Assignee: Redx Pharma LimitedInventors: Mark Craighead, Ronald Palin, Neil Murray, Derek Lindsay
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Patent number: 8877945Abstract: The present invention provides redox drug derivatives. In particular, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester, (3S)-3-(aminomethyl)-5-methylhexanoic acid, (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-?-?-diphenyl-3-pyrrolidineacetamide, (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethyl-butyl]-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid and (2R,3R,4S)-4-[(diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid redox derivatives.Type: GrantFiled: May 17, 2010Date of Patent: November 4, 2014Assignee: Redx Pharma LimitedInventors: Derek Lindsay, Peter Jackson
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Publication number: 20140316135Abstract: Provided are a compound of formula (5) and a process for its preparation wherein: R1 represents an alkyl group; R2 represents an aryl group; R3 represents a protecting group or an alkyl group; R4 represents a protecting group or a SO2R5 group where R5 is an alkyl group; R6 represents (PR7R8)+X? or P(?O)R7R8 in which X is an anion and R7 and R8 each independently is an alkyl, aryl, alkoxy, or aryloxy group; P1 represents hydrogen or a protecting group; and W represents ?O or OP2, in which P2 represents hydrogen or a protecting group.Type: ApplicationFiled: March 25, 2014Publication date: October 23, 2014Applicant: Redx Pharma LimitedInventors: David J. Moody, Jonathan W. Wiffen
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Patent number: 8853429Abstract: There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.Type: GrantFiled: July 26, 2013Date of Patent: October 7, 2014Assignee: Redx Pharma LimitedInventors: David John Moody, Jonathan William Wiffen
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Patent number: 8703945Abstract: There is provided a process for the preparation of a compound of formula (7) wherein R1 represents an alkyl group; R2 represents an aryl group; R3 represents hydrogen, a protecting group or an alkyl group; and R4 represents hydrogen, a protecting group or a SO2R5 group where R5 is an alkyl group, which comprises a) hydroxylating a compound of formula (1) wherein Y represents a halo group; P1 represents hydrogen or a protecting group, and W represents ?O or —OP2, in which P2 represents hydrogen or a protecting group, to give a compound of formula (2), b) oxidixing the compound of formula (2) to give a compound of formula (3), c) coupling the compound of formula (3) with a compound of formula (4), wherein R3 represents a protecting group or an alkyl group; R4 represents a protecting group or a SO2R5 group where R5 is an alkyl group; and R6 represents (PR7R8)+X? or P(?O)R7R8 in which X is an anion and R7 and R8 each independently is an alkyl, aryl.Type: GrantFiled: March 23, 2005Date of Patent: April 22, 2014Assignee: Redx Pharma LimitedInventors: David J. Moody, Jonathan W. Wiffen
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Publication number: 20140018381Abstract: This invention relates to the discovery of novel rosuvastatin analogues. More specifically, the invention relates to novel rosuvastatin analogues which have utility in treating conditions treatable by the inhibition of HMG-CoA reductase.Type: ApplicationFiled: September 17, 2013Publication date: January 16, 2014Applicant: RedX Pharma LimitedInventors: Derek Lindsay, Peter Jackson
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Patent number: 8614335Abstract: There is provided a process for the preparation of a compound of formula (7) or salts thereof: wherein R1 represents a hydrogen or a hydrocarbyl group, R2 represents a hydrogen or substituent group, R3 represents a hydrogen or a hydrocarbyl group, and X represents a hydrogen or substituent group which comprises a) cyanating a compound of formula (1): wherein Y represents a halo group, preferably CI or Br; P1 represents hydrogen or a protecting group, and W represents ?O or —OP2, in which P2 represents hydrogen or a protecting group, to give a compound of formula (2): b) reducing the compound of formula (2) to give a compound of formula (3): coupling the compound of formula (3) with a compound of formula (4): to give a compound of formula (5): when W represents —OP2, deprotecting and then oxidizing the compound of formula (5) to give a compound of formula (6): and e) subjecting the compound of formula (5) when W represents ?O, or compound of formula (6) to ring-opening, and removal of any remaining protectingType: GrantFiled: August 14, 2008Date of Patent: December 24, 2013Assignee: Redx Pharma LimitedInventors: David John Moody, Jonathan William Wiffen
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Patent number: 8519164Abstract: There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.Type: GrantFiled: August 30, 2012Date of Patent: August 27, 2013Assignee: Redx Pharma LimitedInventors: David John Moody, Jonathan William Wiffen
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Patent number: 8278467Abstract: There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.Type: GrantFiled: November 28, 2005Date of Patent: October 2, 2012Assignee: REDX Pharma LimitedInventors: David John Moody, Jonathan William Wiffen