Abstract: This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases andd their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
Type:
Grant
Filed:
July 17, 1987
Date of Patent:
August 25, 1992
Assignees:
Ceskoslovenska Akademie Ved, Rega Institut
Inventors:
Antonin Holy, Ivan Rosenberg, Erik D. A. De Clercq