Patents Assigned to Regent of the Univ. of Minnesota
  • Publication number: 20120213886
    Abstract: The invention provides for a diet that significantly reduces the glycohemoglobin levels in individuals with type 2 diabetes. A diet plan can be provided to an individual in the form of cards and/or pages with an appropriate meal plan, food items and/or pre-packaged meals, or in an electronic medium for the individuals to use to develop appropriate meal plans. The diet comprises food items having a nutritional composition that consists essentially of 30% protein, 50% fats, and 20% carbohydrates, or food items having a nutritional composition that consists essentially of 30% protein, 40% fats, and 30% carbohydrates, and is consumed for a period of three weeks to one year.
    Type: Application
    Filed: February 21, 2012
    Publication date: August 23, 2012
    Applicants: U.S. Dept. of Veterans Affairs, Regents of the Univ. of Minnesota
    Inventors: Mary C. Gannon, Frank Q. Nuttall
  • Patent number: 8142809
    Abstract: The invention provides for a diet that significantly reduces the glycohemoglobin levels in individuals with type 2 diabetes. A diet plan can be provided to an individual in the form of cards and/or pages with an appropriate meal plan, food items and/or pre-packaged meals, or in an electronic medium for the individuals to use to develop appropriate meal plans. The diet comprises food items having a nutritional composition that consists essentially of 30% protein, 50% fats, and 20% carbohydrates, or food items having a nutritional composition that consists essentially of 30% protein, 40% fats, and 30% carbohydrates.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: March 27, 2012
    Assignees: Regent of the Univ. of Minnesota, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Mary C. Gannon, Frank Nuttall
  • Patent number: 5725855
    Abstract: The present invention provides a method for enhancing the immunotherapeutic activity, e.g., antitumor activity, of immune cells by depleting immune cells of a cell subset that down-regulates the immune response, such as either CD4.sup.+ or CD8.sup.+ lymphocytes. The remaining depleted immune cell population or the separated immune cell subsets then are cultured in the presence of an antibody to a lymphocyte surface receptor, preferably an anti-CD3 monoclonal antibody (MoAb), optionally in the presence of a relatively minor amount of interleukin-2 (IL-2). These stimulated cells then are optionally additionally cultured in the presence of IL-2 without an antibody to a lymphocyte surface receptor. The present invention also provides a method of treating a mammal having tumors or immunizing a mammal against tumors by administering the stimulated depleted immune cell population or a stimulated immune cell subset to a mammal, advantageously together with an immunosuppressant, and with liposomal IL-2.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: March 10, 1998
    Assignees: The United States of America as represented by the Department of Health and Human Services, Regents of the Univ. of Minnesota
    Inventors: Augusto Carlos Ochoa, Mark L. Saxton, Dan L. Longo
  • Patent number: 5545544
    Abstract: The white rot fungus Scytinostroma galactinum strain F361 and mutants thereof are particularly effective in selectively grading the lignin component of lignin-containing materials, particularly processed wood pulps including chemical pulps, and also particularly effective in degrading lignin degradation products such as chlorinated degraded lignin by-products as found, for example, in E-1 effluents, and also in degrading chlorine-containing aromatic compounds generally as found in aqueous waste streams containing the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 13, 1996
    Assignees: Sandoz Ltd., The Regents of the Univ. of Minnesota
    Inventors: Robert A. Blanchette, Theresa S. Brush, Roberta L. Farrell, Keith A. Krisa, Chittra Mishra
  • Patent number: 5538752
    Abstract: Compositions comprising melanin or melanin precursors are useful for preventing or controlling decay of substrates such as cellulosic and other porous organic substrates. The compositions provide useful wood preservatives, wound dressings, and the like. In one embodiment, the compositions comprise melanin complexed with metal ions, particularly copper. The compositions may be applied as penetrating or surface treatments. Certain melanins are also particularly useful for removing metal ions from liquids.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: July 23, 1996
    Assignees: Regents of the Univ. of Minnesota, Sandoz Ltd.
    Inventors: Robert A. Blanchette, Theresa S. Brush, Roberta L. Farrell
  • Patent number: 5427945
    Abstract: The white rot fungus Scytinostroma galactinum strain F361 and mutants thereof are particularly effective in selectively grading the lignin component of lignin-containing materials, particularly processed wood pulps including chemical pulps, and also particularly effective in degrading lignin degradation products such as chlorinated degraded lignin by-products as found, for example, in E-1 effluents, and also in degrading chlorine-containing aromatic compounds generally as found in aqueous waste streams containing the same.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: June 27, 1995
    Assignees: Sandoz Ltd., The Regents of the Univ. of Minnesota
    Inventors: Robert A. Blanchette, Theresa S. Brush, Roberta L. Farrell, Keith A. Krisa, Chittra Mishra
  • Patent number: 4755460
    Abstract: A bovine pregnancy antigen, determined to be a glycoprotein, has been isolated and purified. If is diagnostic for the presence of pregnancy in cattle when detected by the use of antibodies to the antigen.
    Type: Grant
    Filed: July 6, 1984
    Date of Patent: July 5, 1988
    Assignee: The Regents of the Univ. of Minnesota
    Inventors: Eileen F. Bostwick, Alan G. Hunter
  • Patent number: 4702108
    Abstract: An apparatus and method for isometric muscle strength testing using a chair apparatus (40) having a support frame structure (42), a seat assembly (46), a foot rest assembly (60) and load cells (100) interconnected to the support frame structure (42) for measuring the isometric force exerted by any of a plurality of muscle groups in a human subject's body. The load cells (100) are possibly positioned on six track systems; a posterior track (80a), left and right lateral tracks (80b,c) an anterior track (80d), a forward upper track (80e) and a forward lower track (80f) to enable alignment with the muscle group selected for testing.
    Type: Grant
    Filed: February 4, 1986
    Date of Patent: October 27, 1987
    Assignees: Regents of the Univ. of Minnesota, Twin City Surgical, Inc.
    Inventors: Louis R. Amundsen, Robert P. Patterson, Tanya L. Baxter, Glenn N. Scudder, Wayne O. Duescher, Willis E. Dahlman, Gary W. Schukar, Clarence I. Steinback