Patents Assigned to Regent of the University of Minnesota
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Patent number: 11987572Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.Type: GrantFiled: June 3, 2020Date of Patent: May 21, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Joseph J. Topczewski, William C. K. Pomerantz, Angela S. Carlson, Huarui Cui, Anand Divakaran
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Patent number: 11986533Abstract: A composition includes a macromolecular polyacrylamide copolymer excipient with an ?-end including a ROMP-active norbornene end-group and a ?-end including a terminal monomer with an end group chosen from: a hydrogen atom (H); or a functionalized acrylate with functionality chosen from alkyl, hydroxyl (OH), methyl-polyethylene glycol ((PEG)-CH3), hydroxy-PEG (PEG-OH), carboxylic acid (COOH), and combinations thereof. A biological compound chosen from active pharmaceutical ingredients, proteins, polynucleotides, and mixtures and combinations thereof is non-covalently bound with the macromolecular excipient.Type: GrantFiled: January 21, 2022Date of Patent: May 21, 2024Assignee: Regents of the University of MinnesotaInventors: Theresa Reineke, Frank S. Bates, Monica Ohnsorg
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Patent number: 11985969Abstract: This disclosure describes a cryopreservative composition and methods for storing cells. Generally, the cryopreservative composition includes a sugar component and a sugar alcohol component, and is effective for storing and recovering cells without requiring dimethyl sulfoxide (DMSO).Type: GrantFiled: July 9, 2021Date of Patent: May 21, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Allison Hubel, Kathryn Lindsay Pollock
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Publication number: 20240156342Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.Type: ApplicationFiled: September 25, 2023Publication date: May 16, 2024Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Robert Vince, Swati Sudhakar More
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Publication number: 20240158722Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.Type: ApplicationFiled: November 21, 2023Publication date: May 16, 2024Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, Regents of the University of MinnesotaInventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
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Patent number: 11981933Abstract: Devices, systems, and techniques are described for printing pre-aligned microtissues into larger tissue constructs. For example, a method of printing a tissue construct includes aligning cells in a first direction to create pre-aligned microtissues, suspending the pre-aligned microtissues in a liquid to create a bioink, and depositing the pre-aligned microtissues in a second direction to create the tissue construct.Type: GrantFiled: August 31, 2021Date of Patent: May 14, 2024Assignee: Regents of the University of MinnesotaInventors: Caleb Darwin Vogt, Angela Panoskaltsis-Mortari
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Patent number: 11980410Abstract: A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.Type: GrantFiled: October 5, 2018Date of Patent: May 14, 2024Assignee: Regents of the University of MinnesotaInventors: Samira M. Azarin, Francisco Pelaez, Navid Manuchehrabadi, John C. Bischof
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Patent number: 11982725Abstract: Magnetic resonance images with improved image quality consistent with those obtained using parallel radio frequency (“RF”) transmission (“pTx”) techniques are generated from data acquired using single transmission hardware (e.g., single channel RF transmission). A deep-learning framework is used to train a deep neural network to convert images obtained with single transmission into pTx-like images. The pTx-like images have reduced signal variations and dropouts that may otherwise be attributable to B1+ inhomogeneities.Type: GrantFiled: May 2, 2022Date of Patent: May 14, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Xiaoping Wu, Xiaodong Ma, Kamil Ugurbil
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Patent number: 11979290Abstract: Systems and methods are disclosed for parallelizing service function chains.Type: GrantFiled: November 14, 2022Date of Patent: May 7, 2024Assignees: AT&T Intellectual Property I, L.P., Regents of the University of MinnesotaInventors: Bo Han, Vijay Gopalakrishnan, Muhammad Bilal Anwer, Zhi-Li Zhang, Yang Zhang
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Patent number: 11968975Abstract: A lyoprotectant composition includes one or more lyoprotective carbohydrates comprising a non-reducing polysaccharide. The non-reducing polysaccharide may be dextranol. The one or more lyoprotective carbohydrates may include a non-reducing disaccharide. The lyoprotectant composition may be free of or substantially free of reducing sugars. The composition may be in the form of a matrix including a non-woven web of fibers having an average diameter of 0.1 ?m to 2.5 ?m. A method of storing a liquid biospecimen includes mixing the liquid biospecimen with the lyoprotectant composition to prepare a specimen-loaded composition; drying the specimen-loaded composition; and storing the dried specimen-loaded composition.Type: GrantFiled: April 28, 2020Date of Patent: April 30, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Bryan Jones, Alptekin Aksan, Advitiya Mahajan
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Patent number: 11969470Abstract: The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.Type: GrantFiled: July 23, 2021Date of Patent: April 30, 2024Assignee: Regents of the University of MinnesotaInventor: James C. Cloyd
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Patent number: 11965190Abstract: Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin.Type: GrantFiled: September 7, 2018Date of Patent: April 23, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Yiannis John Kaznessis, Seth Ritter, Benjamin Hackel
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Patent number: 11965950Abstract: A method for generating a perfusion weighted image using arterial spin labeling (ASL) with segmented acquisitions includes dividing an anatomical area of interest into a plurality of slices and performing a multi-band (MB) echo planar imaging (EPI) acquisition process using a magnetic resonance imaging (MRI) system to acquire a control image dataset representative of the plurality of slices using a central-to-peripheral or peripheral-to-central slice acquisition order. An ASL preparation process is performed using the MRI system to magnetically label protons in arterial blood water in an area upstream from the anatomical area of interest. Following a post-labeling delay time period, the MB EPI acquisition process is performed to a labeled image dataset corresponding to the slices using the central-to-peripheral or peripheral-to-central slice acquisition order. A perfusion weighted image of the anatomical area is generated by subtracting the labeled image dataset from the control image dataset.Type: GrantFiled: July 29, 2019Date of Patent: April 23, 2024Assignees: Siemens Healthineers AG, Regents of the University of MinnesotaInventors: Xiufeng Li, Gregory J. Metzger, Essa Yacoub, Kamil Ugurbil, Dingxin Wang
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Publication number: 20240124550Abstract: A recombinant immune cell expresses a heterologous IgG Fc receptor. In some embodiments, the heterologous IgG Fc receptor can be a chimeric IgG Fc receptor. Generally, the chimeric IgG Fc receptor includes an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain generally includes a sufficient portion of CD64 to bind to an IgG Fc region. The intracellular domain of the chimeric IgG Fc receptor includes a sufficient portion of an Fc receptor allowing immunoreceptor tyrosine-based activation motif (ITAM) to initiate cell signaling when an IgG Fc region binds to the extracellular domain.Type: ApplicationFiled: September 26, 2023Publication date: April 18, 2024Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Jianming Wu, Bruce Kenneth Walcheck, Robert Harrison Hullsiek, Yungfang Li, Hemant Kumar Mishra
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Patent number: 11962514Abstract: Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function.Type: GrantFiled: February 13, 2023Date of Patent: April 16, 2024Assignees: AT&T Intellectual Property I, L.P, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Bo Han, Vijay Gopalakrishnan, Muhammad Bilal Anwer, Zhi-Li Zhang, Yang Zhang
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Publication number: 20240115863Abstract: A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.Type: ApplicationFiled: January 26, 2022Publication date: April 11, 2024Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), CORNELL UNIVERSITYInventors: Alik WIDGE, Mahsa SHOARAN, Uisub SHIN
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Patent number: 11951416Abstract: A system includes an evaporator having sensors and selectable operational parameters and a controller configured to receive data and determine operational configuration for the evaporator. Selectable parameters relate to system heating, liquid flow rate, air flow rate, and environmental data.Type: GrantFiled: September 12, 2022Date of Patent: April 9, 2024Assignee: Regents of the University of MinnesotaInventors: Mustafa F. Kaddoura, Natasha C. Wright
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Publication number: 20240109872Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.Type: ApplicationFiled: August 11, 2023Publication date: April 4, 2024Applicant: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Narsihmulu Cheryala
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Patent number: 11946452Abstract: Control systems are described that mitigate the effects of icing events on wind turbines. Example methods include determining, with a control system, that an icing event has begun to affect the wind turbine; based on a determination that the icing event has begun to affect the wind turbine, changing a phase of the wind turbine with the control system to an operational-icing phase by modifying angles of attack of blades of the wind turbine via changing blade pitch angles, wherein the wind turbine continues to generate electrical power when the wind turbine is in the operational-icing phase; and based on a determination that electrical power generation of the wind turbine is below a threshold, changing the phase of the wind turbine with the control system to a stopped-icing phase, wherein rotation of the blades of the wind turbine is halted when the wind turbine is in the stopped-icing phase.Type: GrantFiled: July 13, 2021Date of Patent: April 2, 2024Assignee: Regents of the University of MinnesotaInventors: Jiarong Hong, Linyue Gao
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Patent number: 11946935Abstract: Methods and diagnostic compositions for detecting and monitoring meningiomas.Type: GrantFiled: August 25, 2021Date of Patent: April 2, 2024Assignee: Regents of the University of MinnesotaInventors: Nurten Saydam, Okay Saydam