Patents Assigned to Regentis Biomaterials Ltd.
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Publication number: 20220105240Abstract: The present invention provides protein-polymer conjugates, and methods for generating biocompatible scaffolds formed of hydrogels comprising the conjugates and use of the scaffolds for tissue regeneration. The present invention provides improved processes for the preparation of the conjugates, wherein the conjugates of the invention are preferably produced in an environmentally friendly process avoiding polar organic solvents.Type: ApplicationFiled: December 17, 2021Publication date: April 7, 2022Applicant: REGENTIS BIOMATERIALS LTD.Inventors: Yonatan SHACHAF, Raz SIMON, Koby GVILI
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Patent number: 10434215Abstract: A pharmaceutical, cosmetic or cosmeceutical composition which exhibits a reverse thermal gelation is disclosed herein, as well as a composition-of-matter comprising a cross-linked form of the composition, and a process for producing the composition-of-matter. The composition is characterized as exhibiting a shear storage modulus of at least 100 Pa at temperatures in a range of from 17° C. to 21° C., and a shear storage modulus of less than 100 Pa at a temperature of 4° C., and as being curable in a physiological medium, and/or comprises a polymer-polypeptide conjugate comprising a polypeptide having attached thereto at least two polymeric moieties, wherein at least one of said polymeric moieties further comprises at least one polymerizable group; a poloxamer; and a poloxamer substituted by at least one polymerizable group. Further disclosed herein are uses of the composition and/or composition-of-matter in the treatment of tissue damage or loss.Type: GrantFiled: June 26, 2014Date of Patent: October 8, 2019Assignee: Regentis Biomaterials Ltd.Inventors: Yonatan Shachaf, Aharon Wechsler
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Publication number: 20190083642Abstract: A composition for use in treating a condition associated with degeneration of articular cartilage and/or with subchondral bone loss is disclosed herein. The composition comprises a conjugate which comprises a polypeptide having attached thereto at least two polymeric moieties, at least one of the polymeric moieties exhibiting a reverse thermal gelation. Further disclosed is a composition comprising the aforementioned conjugate along with a hyaluronic acid, an anti-inflammatory agent, an analgesic, a growth factor, a blood fraction, a nucleic acid, and/or a cell, the composition being an aqueous composition which forms a hydrogel at a temperature in a range of from 32° C. to 37° C., as well as a method utilizing such a composition comprising a nucleic acid for effecting gene delivery.Type: ApplicationFiled: March 30, 2017Publication date: March 21, 2019Applicant: Regentis Biomaterials Ltd.Inventors: Yonatan SHACHAF, Aharon WECHSLER
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Publication number: 20180361021Abstract: The present invention provides protein-polymer conjugates, and methods for generating biocompatible scaffolds formed of hydrogels comprising the conjugates and use of the scaffolds for tissue regeneration. The present invention provides improved processes for the preparation of the conjugates, wherein the conjugates of the invention are preferably produced in an environmentally friendly process avoiding polar organic solvents.Type: ApplicationFiled: December 14, 2016Publication date: December 20, 2018Applicant: REGENTIS BIOMATERIALS LTD.Inventors: Yonatan SHACHAF, Raz SIMON, Koby GVILI
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Patent number: 9895519Abstract: Apparatus and methods are described, including apparatus for treating a cavity in a human body, the apparatus including a delivery tube. A bather device has a collapsed configuration and an expanded configuration, the barrier device moving from the collapsed configuration to the expanded configuration upon being deployed from the delivery tube. A pushing element, slidably disposed within a lumen of the delivery tube, is configured to deploy the barrier device from the delivery tube by pushing the bather device. One or more bather-deployment elements are coupled to the barrier device and to the pushing element, the bather-deployment elements being configured to conformingly contact the barrier device with tissue surrounding the cavity. Other applications are also described.Type: GrantFiled: October 6, 2014Date of Patent: February 20, 2018Assignee: REGENTIS BIOMATERIALS LTD.Inventors: Boaz Harari, Amir Perle, Raz Simon
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Patent number: 9872705Abstract: Apparatus and methods are described, including apparatus for treating a cavity in a human body, the apparatus including a delivery tube. A barrier device has a collapsed and an expanded configuration, the barrier device moving from the collapsed to the expanded configuration upon being deployed from the delivery tube. A pushing element, slidably disposed within a lumen of the delivery tube, deploys the barrier device from the delivery tube by pushing the barrier device. One or more barrier-deployment elements are coupled to the barrier device and to the pushing element, the barrier-deployment elements being configured to conformingly contact the barrier device with tissue surrounding the cavity. The barrier device is configured to isolate the cavity from surrounding body fluid that is between the barrier device and the pushing element, following deployment of the barrier device from the delivery tube. Other applications are also described.Type: GrantFiled: April 6, 2015Date of Patent: January 23, 2018Assignee: REGENTIS BIOMATERIALS LTD.Inventors: Boaz Harari, Amir Perle, Raz Simon
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Patent number: 9700600Abstract: A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.Type: GrantFiled: August 31, 2015Date of Patent: July 11, 2017Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Liora Almany
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Publication number: 20170182214Abstract: The present invention relates to scaffolds composed of a protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-thiolated collagen scaffolds and PEGylated albumin scaffolds and methods of generating and using same for treating disorders requiring tissue engineering.Type: ApplicationFiled: March 15, 2017Publication date: June 29, 2017Applicant: Regentis Biomaterials Ltd.Inventors: Dror SELIKTAR, Maya GONEN-WADMANY
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Patent number: 9624259Abstract: The present invention relates to scaffolds composed of a protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-thiolated collagen scaffolds and PEGylated albumin scaffolds and methods of generating and using same for treating disorders requiring tissue engineering.Type: GrantFiled: April 16, 2008Date of Patent: April 18, 2017Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Maya Gonen-Wadmany
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Publication number: 20160375174Abstract: The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.Type: ApplicationFiled: September 8, 2016Publication date: December 29, 2016Applicant: Regentis Biomaterials Ltd.Inventors: Dror SELIKTAR, Liora ALMANY
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Patent number: 9474830Abstract: The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.Type: GrantFiled: October 13, 2014Date of Patent: October 25, 2016Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Liora Almany
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Publication number: 20150359856Abstract: A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.Type: ApplicationFiled: August 31, 2015Publication date: December 17, 2015Applicant: REGENTIS BIOMATERIALS LTD.Inventors: Dror SELIKTAR, Liora ALMANY
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Patent number: 9120872Abstract: A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.Type: GrantFiled: October 27, 2010Date of Patent: September 1, 2015Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Liora Almany
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Publication number: 20150209562Abstract: Apparatus and methods are described, including apparatus for treating a cavity in a human body, the apparatus including a delivery tube. A barrier device has a collapsed and an expanded configuration, the barrier device moving from the collapsed to the expanded configuration upon being deployed from the delivery tube. A pushing element, slidably disposed within a lumen of the delivery tube, deploys the barrier device from the delivery tube by pushing the barrier device. One or more barrier-deployment elements are coupled to the barrier device and to the pushing element, the barrier-deployment elements being configured to conformingly contact the barrier device with tissue surrounding the cavity. The barrier device is configured to isolate the cavity from surrounding body fluid that is between the barrier device and the pushing element, following deployment of the barrier device from the delivery tube. Other applications are also described.Type: ApplicationFiled: April 6, 2015Publication date: July 30, 2015Applicant: REGENTIS BIOMATERIALS LTD.Inventors: Boaz HARARI, Amir PERLE, Raz SIMON
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Patent number: 8858925Abstract: The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.Type: GrantFiled: July 13, 2011Date of Patent: October 14, 2014Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Liora Almany
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Patent number: 8846020Abstract: Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.Type: GrantFiled: December 16, 2010Date of Patent: September 30, 2014Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Yonatan Shachaf
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Publication number: 20120258068Abstract: Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.Type: ApplicationFiled: December 16, 2010Publication date: October 11, 2012Applicant: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Shachaf Yonatan
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Publication number: 20120020911Abstract: The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.Type: ApplicationFiled: July 13, 2011Publication date: January 26, 2012Applicant: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Liora Almany
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Patent number: 8007774Abstract: The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.Type: GrantFiled: June 22, 2006Date of Patent: August 30, 2011Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Liora Almany
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Publication number: 20110038828Abstract: A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.Type: ApplicationFiled: October 27, 2010Publication date: February 17, 2011Applicant: REGENTIS BIOMATERIALS LTD.Inventors: DROR SELIKTAR, LIORA ALMANY