Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, and R4 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.

Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.

Abstract: A system includes control circuitry configured to control an output signal. The control circuitry and/or various other sources of undesirable signal components may corrupt the control signal used by the control circuitry to correct the output signal. Conditioning circuitry may effect current-domain repair on the control circuitry by providing feedback-based conditioning actuation, including comparator overdrive, to the control circuitry.

Abstract: Systems and methods are provided for wireless power transfer in a vehicle. A wireless power transfer system can include a high-frequency alternating current (HFAC) inverter electrically coupled to the power source and a transmitter to wirelessly transmit a HFAC power signal to at least one device of a vehicle, such as sensors (e.g., LiDAR, GPS etc.) and cameras. The HFAC power signal provides wireless power and a data signal to the at least one device of a vehicle. The wireless power transfer system can eliminate the need for cabling and wires to provide power to the device. Wireless power transfer can include use or a data modulation circuit and a pulse current source to inject a pulse current to the HFAC power signal as superimposed data. System configurations can power a plurality of devices. Systems can includes a plurality of HFAC inverters and transmitters to power multiple sets of devices.

Abstract: Crossbar arrays perform analog vector-matrix multiplication naturally and provide a building block for modern computing systems. Specialized mixed-signal interface circuits are interfaced with the rows and columns of the crossbar arrays. During operation, the mixed-signal interface circuits provide high voltages for write operations and low voltages for read operations. This disclosure presents improved designs for the mixed-signal interface circuits which minimize the number of switches as well as the number level shifters.

Abstract: There is disclosed squaraine compounds of formula I: wherein each of Y1 and Y2 is independently chosen from an optionally substituted amino group and an optionally substituted aryl group. Also described are organic optoelectronic devices comprising a Donor-Acceptor heterojunction that is formed from one or more of the squaraine compounds. A method of making the disclosed device, which may include one or more sublimation step for depositing said squaraine compound, is also disclosed.

Abstract: An autonomous vehicle configured to autonomously pass a cyclist includes an imaging device and processing circuitry configured to receive information from the imaging device. Additionally, the processing circuitry of the autonomous vehicle is configured to identify a cyclist passing situation based on the information received from the imaging device, and plan a path of an autonomous vehicle based on the cyclist passing situation. The autonomous vehicle also includes a positioning system and the processing circuitry is further configured to receive information from the positioning system, determine if the cyclist passing situation is sufficiently identified, and identify the cyclist passing situation based on the information from the imaging device and the positioning system when the cyclist passing situation is not sufficiently identified based on the information received from the imaging device.

Abstract: Plasmonic nanostructures function as an antenna-reactor nanostructure to focus and convert light into thermal/chemical energy, and thus have significant potential for sustainable solar water disinfection. However, the insufficient energy harvesting efficiency resulting from inconsistent nano-features linked with arrangement and scaling is a persistent challenge. An integrated optofluidic fabrication method is presented to produce a high density integrative plasmonic dimer array to enhance solar water disinfection. The plasmonic dimer array is constructed by a combined fabrication of self-assembly monolayer method and block-co-polymer lithography approaches. This combination leads to a two-dimensional hexagonal array of dimer structures consisting of 1.3 nm nanogap. The uniformity and high density of the nanogaps in the plasmonic dimer array allows strong light focusing and a rapid and highly efficient harvesting of photothermal energy at visible and near-infrared region.

Abstract: A tandem photovoltaic (PV) may include III-V semiconductors, silicon, a cathode electrode, an anode electrode, and a gold-to-gold metal bridge electrode. The semiconductors include p-typed and n-typed regions. To form a tandem PV structure, bottom and top PV cells can be independently fabricated. The bottom and the top PV cells are electrically connected by the gold-to-gold metal bridge interconnection, which is positioned between the bottom and the top PV cells. The metal bridge may be formed by cold-welding compression technique. This structure is compatible to the development of tandem PVs as well as thermophotovoltaic (TPV) cells.

Abstract: An enclosed multi-dimensional system for converting electromagnetic (EM) energy into electricity. An electromagnetic energy convertor (EMEC) device comprises a plurality of electromagnetic (EM) energy converting cells disposed in a single-piece, at-least-partially transparent, insulating medium selected from a list of luminescent, transmissive, absorptive, diffusive, refractive, dispersive, conductive, and dielectric materials or a combination thereof. The medium facilitates the propagation of the electromagnetic energy within the EMEC device and helps to optimize its conversion to electricity by the plurality of electromagnetic (EM) energy converting cells. The plurality of electromagnetic (EM) energy converting cells are disposed at least partially within the medium.

Abstract: An actuated telescoping system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defining a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen.

Abstract: Provided herein are compositions and methods for increasing butyrate production in a subject. In particular, provided herein are compositions, probiotic compositions, and combinations thereof that promote butyrate production in a subject.

Abstract: A metalens configured to shape the focus light into a flexibly designed pattern. The present teachings demonstrate the engineering of metalens with artificial focus pattern by creating line and ring-shaped focus as ‘drawing tools’. These metalens are fabricated through a single layer of silicon-based material through CMOS compatible nano fabrication process. The mechanism to generate artificial focus pattern can be applied to a plethora of future on-chip optical devices with applications ranging from beam engineering to next generation nano lithography.

Abstract: A method for processing a video stream includes obtaining frame data of a current frame of the video stream, determining frame difference data based on a comparison of the frame data of the current frame and scene cache data for a previous frame of the video stream, the scene cache data being stored in a scene cache for the video stream, determining, based on the frame difference data, regions of the video stream to be re-sampled at a higher resolution than the frame data, obtaining re-sampling data for the determined regions, updating the scene cache data based on the obtained frame data and the re-sampling data, and providing the re-sampling data to a processor to update an analysis scene cache for the video stream.

Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) by obtaining scan data of a sample at a low-resolution over a k-space and obtaining other scan data at a high-resolution over the k-space. This scan data may be captured over the same regions, different regions, or where one scan data is captured over a sub-region of the other. The low-resolution and high-resolution scanning is repeated according to a scanning ratio between the first scan data and the second scan data to generate interleaved low-resolution and high-resolution scan data. From that interleaved low-resolution and high-resolution scan data, high-resolution tissue property maps of the sample are generated.

Abstract: A progressive cellular architectures has been presented for vapor-phase chemical analyzers. The progressive cellular architecture consists of a series of heterogeneous micro-gas chromatography cells. Each individual cell targets vapor species within a specific volatility range by using a unique combination of a preconcentrator and a separation column. The cells are connected progressively in series to cover a broad range of volatile analyte chemical vapors. Valves may inadvertently absorb or adsorb and subsequently release target chemical analyte molecules, thereby interfering with quantitative analysis. Therefore, the inlet to the cells is configured without a valve.

Abstract: A magneto-inductive DC magnetometer is provided that is operable to output fluxgate quality measurements in a low mass, volume, power and cost package. The magnetometer enables constellation-class missions not only due to its low-resource requirements, but also due to its potential for commercial integrated circuit fabrication. In addition, the magnetometer will be part of a ground-based Space Weather Underground Citizen Science instrument package that enables dense arrays of space weather-relevant observations at mid-latitudes. The magneto-inductive operating principle is based on a simple resistance-inductor (RL) circuit and involves measurement of the time it takes to charge and discharge the inductor between an upper and lower threshold by means of a Schmitt trigger oscillator. This time is proportional to the inductance that in turn is proportional to the field strength.

Abstract: The present application can provide a preparation method that can effectively produce a polymer having desired molecular weight characteristics and solubility in a solvent, and having a monomer composition, which is designed freely and variously according to the purpose, without unnecessary components with excellent polymerization efficiency and conversion rates, and a dispersion comprising the polymer formed by the preparation method.

Abstract: A computer system includes memory hardware configured to store a multitask neural network, an optimization model, a material database, material feature vector inputs, and computer-executable instructions which include training the multitask neural network with the material feature vector inputs to generate a material structural parameter output, obtaining at least one of a target optical perception parameter and a target optical response, supplying the target optical perception parameter or target optical response and at least two of the multiple material data structures of the material database to the multitask neural network to output the at least one predicted material and the predicted structural parameter distribution, processing, by the optimization model, the predicted structural parameter distribution to generate a tuned structural parameter output, and transmitting the at least one predicted material and the tuned structural parameter output to a computing device to facilitate generation of an optica