Patents Assigned to Rempex Pharmaceuticals, Inc.
  • Synthesis of boronate salts and uses thereof
    Patent number: 10669292
    Abstract: Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: June 2, 2020
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Scott Hecker, Serge Boyer
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 10639318
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: May 5, 2020
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 10561675
    Abstract: Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 18, 2020
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: David C. Griffith, Michael N. Dudley, Olga Rodny
  • Synthesis of boronate salts and uses thereof
    Patent number: 10385074
    Abstract: Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: August 20, 2019
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Scott Hecker, Serge Boyer
  • Apparatus and continuous flow process for production of boronic acid derivatives
    Patent number: 10364257
    Abstract: A process for a continuous production of a boronic acid derivative based on a Matteson boronic ester homologation and an apparatus of performing the process are disclosed.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: July 30, 2019
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Ulfried Felfer, Clemens Stueckler, Stefan Steinhofer, Andreas Pelz, Marcus Hanacek, Thomas Heinrich Pabst, George Winkler, Peter Poechlauer, Bas Ritzen, Michel Goldbach
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 10183034
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 22, 2019
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 10172874
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 8, 2019
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Cyclic boronic acid ester derivatives and methods of making the same
    Patent number: 10004758
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: June 26, 2018
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Boronic acid derivatives and therapeutic uses thereof
    Patent number: 9963467
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 8, 2018
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja Reddy, Tomasz Glinka, Scott Hecker, Maxim Totrov, Olga Rodny
  • Tetracycline compositions
    Patent number: 9744179
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 29, 2017
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: David C. Griffith, Serge Boyer, Scott Hecker, Michael N. Dudley
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 9694025
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: July 4, 2017
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 9687497
    Abstract: Disclosed herein is the crystalline form of the potassium salt of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid. The crystalline form maybe formulated for treating subjects with bacterial infection. Accordingly, some embodiments relate to compositions and methods of administering the potassium salt of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 27, 2017
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Joanna A. Bis, Pingyun Chen, Senthil Kumar Kusalakumari Sukumar
  • BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20170136047
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Application
    Filed: June 29, 2015
    Publication date: May 18, 2017
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: Raja K. Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker, Olga Rodny
  • Boronic acid derivatives and therapeutic uses thereof
    Patent number: 9642869
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents. Other embodiments relate to pharmaceutical compositions containing boronic acid derivatives and additional excipient such as meglumine.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: May 9, 2017
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja K. Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 9296763
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: March 29, 2016
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Tetracycline compositions
    Patent number: 9278105
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: March 8, 2016
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: David C. Griffith, Serge Boyer, Michael N. Dudley, Scott Hecker
  • Boronic acid derivatives and therapeutic uses thereof
    Patent number: 9241947
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 26, 2016
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker
  • Boronic acid derivatives and therapeutic uses thereof
    Patent number: 9156858
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: October 13, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker
  • Boronic acid derivatives and therapeutic uses thereof
    Patent number: 9132140
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: September 15, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja K. Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker
  • Boronic acid derivatives and therapeutic uses thereof
    Patent number: 9101638
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 11, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker