Patents Assigned to RenovoRx, Inc.
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Patent number: 11541211Abstract: Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.Type: GrantFiled: December 21, 2021Date of Patent: January 3, 2023Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Imtiaz L. Qureshi, Kamran Najmabadi, Shaun R. Bagai
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Patent number: 11052224Abstract: Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.Type: GrantFiled: November 15, 2019Date of Patent: July 6, 2021Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Kamran Najmabadi, Shaun Bagai
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Publication number: 20200206481Abstract: Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.Type: ApplicationFiled: November 15, 2019Publication date: July 2, 2020Applicant: RenovoRx, Inc.Inventors: Ramtin AGAH, Imtiaz L. QURESHI, Kamran NAJMABADI, Shaun R. BAGAI
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Patent number: 10695543Abstract: Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.Type: GrantFiled: November 8, 2017Date of Patent: June 30, 2020Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Kamran Najmabadi, Shaun R. Bagai
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Publication number: 20200078555Abstract: Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.Type: ApplicationFiled: November 15, 2019Publication date: March 12, 2020Applicant: RenovoRx, Inc.Inventors: Ramtin AGAH, Kamran NAJMABADI, Shaun BAGAI
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Patent number: 10512761Abstract: Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.Type: GrantFiled: November 15, 2016Date of Patent: December 24, 2019Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Imtiaz L. Qureshi, Kamran Najmabadi, Shaun R. Bagai
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Publication number: 20180333563Abstract: Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.Type: ApplicationFiled: November 8, 2017Publication date: November 22, 2018Applicant: RenovoRx, Inc.Inventors: Ramtin AGAH, Kamran NAJMABADI, Shaun R. BAGAI
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Patent number: 10099040Abstract: In some embodiments, an apparatus includes a first catheter movably disposed within a first lumen of a second catheter. The first catheter has a first occlusion member disposed at a distal end portion and the second catheter has a second occlusion member disposed at a distal end portion. A third catheter has a third occlusion member disposed at a distal end portion and is moveably disposable within a second lumen of the second catheter. The second catheter has a side port in fluid communication with the second lumen and the third catheter can be extended out of the second lumen through the side port. The first occlusion member, second occlusion member and third occlusion member can collectively isolate a target region including a portion of a first body lumen (e.g., a main vessel) and a portion of a second body lumen (e.g., a branch of the main vessel).Type: GrantFiled: December 3, 2015Date of Patent: October 16, 2018Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Kamran Najmabadi, Shaun R. Bagai, Reza Malek
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Publication number: 20170157370Abstract: In some embodiments, an apparatus includes a first catheter movably disposed within a first lumen of a second catheter. The first catheter has a first occlusion member disposed at a distal end portion and the second catheter has a second occlusion member disposed at a distal end portion. A third catheter has a third occlusion member disposed at a distal end portion and is moveably disposable within a second lumen of the second catheter. The second catheter has a side port in fluid communication with the second lumen and the third catheter can be extended out of the second lumen through the side port. The first occlusion member, second occlusion member and third occlusion member can collectively isolate a target region including a portion of a first body lumen (e.g., a main vessel) and a portion of a second body lumen (e.g., a branch of the main vessel).Type: ApplicationFiled: December 3, 2015Publication date: June 8, 2017Applicant: RenovoRx, Inc.Inventors: Ramtin AGAH, Kamran NAJMABADI, Shaun R. BAGAI, Reza MALEK
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Patent number: 9463304Abstract: An apparatus includes an inner catheter that is coupled to a handle and defines a lumen configured to receive a guidewire. An outer catheter is movably coupled to the handle and defines a first lumen in fluid communication with a distal opening and that is configured to introduce a therapeutic agent through the distal opening and into a target pancreatic artery(ies). The outer catheter defines a second lumen configured to receive at least a portion of the inner catheter. An actuator is coupled to the handle and configured to move the outer catheter relative to the handle. A first occlusion element is coupled to the inner catheter and a second occlusion element is coupled to the outer catheter and disposed proximal to the first occlusion element. A distance between the first occlusion element and the second occlusion element is adjustable when the outer catheter is moved relative to the handle.Type: GrantFiled: September 30, 2015Date of Patent: October 11, 2016Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Kamran Najmabadi, Marta Gaia Zanchi
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Patent number: 9457171Abstract: An apparatus includes an inner catheter that is coupled to a handle and defines a lumen configured to receive a guidewire. An outer catheter is movably coupled to the handle and defines a first lumen in fluid communication with a distal opening and that is configured to introduce a therapeutic agent through the distal opening and into a target pancreatic artery(ies). The outer catheter defines a second lumen configured to receive at least a portion of the inner catheter. An actuator is coupled to the handle and configured to move the outer catheter relative to the handle. A first occlusion element is coupled to the inner catheter and a second occlusion element is coupled to the outer catheter and disposed proximal to the first occlusion element. A distance between the first occlusion element and the second occlusion element is adjustable when the outer catheter is moved relative to the handle.Type: GrantFiled: June 2, 2014Date of Patent: October 4, 2016Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Kamran Najmabadi, Marta Gaia Zanchi
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Publication number: 20160082178Abstract: In some embodiments, a method includes introducing a catheter device into a target artery within a patient where the target artery is near a tumor. The catheter device includes a distal occlusion member and a proximal occlusion member spaced apart from the distal occlusion member. The distal occlusion member is positioned relative to the proximal occlusion member such that an isolated region of the target artery is defined between the distal occlusion member and the proximal occlusion member causing cessation of blood flow in the isolated region. A contrast agent is injected into the target artery and travels to at least one feeder vessel leading to the tumor. A target region in the patient, including the target artery and the tumor, is imaged and a tumor feeder vessel is identified within an image based on the contrast agent visible within the tumor feeder vessel within the image.Type: ApplicationFiled: December 3, 2015Publication date: March 24, 2016Applicant: RenovoRx, Inc.Inventors: Ramtin AGAH, Kamran NAJMABADI, Shaun R. BAGAI
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Publication number: 20160015948Abstract: An apparatus includes an inner catheter that is coupled to a handle and defines a lumen configured to receive a guidewire. An outer catheter is movably coupled to the handle and defines a first lumen in fluid communication with a distal opening and that is configured to introduce a therapeutic agent through the distal opening and into a target pancreatic artery(ies). The outer catheter defines a second lumen configured to receive at least a portion of the inner catheter. An actuator is coupled to the handle and configured to move the outer catheter relative to the handle. A first occlusion element is coupled to the inner catheter and a second occlusion element is coupled to the outer catheter and disposed proximal to the first occlusion element. A distance between the first occlusion element and the second occlusion element is adjustable when the outer catheter is moved relative to the handle.Type: ApplicationFiled: September 30, 2015Publication date: January 21, 2016Applicant: RENOVORX, INC.Inventors: Ramtin AGAH, Kamran NAJMABADI, Marta Gaia ZANCHI
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Publication number: 20140276135Abstract: An apparatus includes an inner catheter that is coupled to a handle and defines a lumen configured to receive a guidewire. An outer catheter is movably coupled to the handle and defines a first lumen in fluid communication with a distal opening and that is configured to introduce a therapeutic agent through the distal opening and into a target pancreatic artery(ies). The outer catheter defines a second lumen configured to receive at least a portion of the inner catheter. An actuator is coupled to the handle and configured to move the outer catheter relative to the handle. A first occlusion element is coupled to the inner catheter and a second occlusion element is coupled to the outer catheter and disposed proximal to the first occlusion element. A distance between the first occlusion element and the second occlusion element is adjustable when the outer catheter is moved relative to the handle.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicant: RenovoRX, Inc.Inventors: Ramtin Agah, Kamran Najmabadi, Marta Gaia Zanchi
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Patent number: 8821476Abstract: Devices and methods are described herein for engraftment of stem cells into a pancreas using an endovascular approach. Targeted intra-arterial injection of stem cells selectively in a splenic artery can achieve engraftment of insulin producing cells in the tail of the pancreas with high efficiency and without systemic circulation of these cells to other organs. In one embodiment, a catheter device includes expandable occlusion elements in the form of inflatable balloons that can be used to isolate a proximal and distal end of a pancreatic portion of the splenic artery. In another embodiment, the occlusion elements include a filter element instead of a balloon. In some embodiments, targeted delivery of stem cells to the pancreatic tail can be achieved for treatment of, for example, diabetes. In some embodiments, an arterial section of the splenic artery can be isolated for selective perfusion of therapeutic cells/drugs to the tail of the pancreas.Type: GrantFiled: December 2, 2010Date of Patent: September 2, 2014Assignee: RenovoRx, Inc.Inventors: Ramtin Agah, Kamran Najmabadi