Abstract: Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
Type:
Grant
Filed:
June 17, 2014
Date of Patent:
April 24, 2018
Assignees:
The University of North Carolina at Chapel Hill, Rensselaer Polyechnic Institute, NUtech Ventures
Inventors:
Jian Liu, Yongmei Xu, Robert J. Linhardt, Edward Harris