Patents Assigned to Rensselaer Polyechnic Institute
  • Patent number: 9951149
    Abstract: Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: April 24, 2018
    Assignees: The University of North Carolina at Chapel Hill, Rensselaer Polyechnic Institute, NUtech Ventures
    Inventors: Jian Liu, Yongmei Xu, Robert J. Linhardt, Edward Harris