Patents Assigned to Replidyne, Inc.
  • Antibacteriall heterocyclic ureas
    Patent number: 8716320
    Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 6, 2014
    Assignee: Replidyne, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun
  • BACTERIAL REPLICATION SYSTEMS AND METHODS
    Publication number: 20100028862
    Abstract: Reconstituted bacterial replication assemblies and methods for their use are provided.
    Type: Application
    Filed: April 26, 2005
    Publication date: February 4, 2010
    Applicant: Replidyne,Inc.
    Inventors: Thale Cross Jarvis, Charles S. McHenry, Nebojsa Janjic, Garry Dallmann, James M. Bullard, Stacie Bell, Glenn Sanders, Frank Dean
  • METHODS AND COMPOUNDS FOR TREATMENT OF CLOSTRIDIUM BASED INFECTION
    Publication number: 20090163536
    Abstract: Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in Clostridium based infection.
    Type: Application
    Filed: September 11, 2007
    Publication date: June 25, 2009
    Applicant: REPLIDYNE, INC.
    Inventors: JOSEPH GUILES, XICHENG SUN, NEBOJSA JANJIC, SARAH STRONG
  • Methionyl tRNA Synthetase Polynucleotides
    Publication number: 20090092592
    Abstract: The invention provides metS polypeptides and DNA (RNA) encoding metS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metS polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: October 19, 2007
    Publication date: April 9, 2009
    Applicant: REPLIDYNE, INC.
    Inventor: Elizabeth Jane Lawlor
  • Transition metal catalyzed cross-coupling of 1-halo-1-haloalkene compounds
    Publication number: 20090054667
    Abstract: Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.
    Type: Application
    Filed: August 9, 2006
    Publication date: February 26, 2009
    Applicant: Replidyne, Inc.
    Inventors: Joseph W. Guiles, Jian Qiu, Theodore M. Tarasow
  • Substituted Phenylether-Thienopyridone Compounds With Antibacterial Activity
    Publication number: 20080227808
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side phenylether constituent and a right hand side thienopyridone constituent. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Application
    Filed: September 11, 2007
    Publication date: September 18, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: JOSEPH GUILES, XICHENG SUN, NEBOJSA JANJIC, SARAH STRONG
  • Antibacterial heterocyclic ureas
    Publication number: 20080207703
    Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
    Type: Application
    Filed: July 23, 2007
    Publication date: August 28, 2008
    Applicant: Replidyne, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun
  • Transition Metal Catalyzed Cross-Coupling Of 1-Halo-1-Haloalkene Compounds
    Publication number: 20080194842
    Abstract: Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.
    Type: Application
    Filed: August 9, 2006
    Publication date: August 14, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: Joseph W. Guiles, Jian Qiu, Theodore M. Tarasow
  • Substituted Thienopyridone Compounds With Antibacterial Activity
    Publication number: 20080146609
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Application
    Filed: September 11, 2007
    Publication date: June 19, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: Joseph GUILES, Xicheng SUN, Nebojsa JANJIC, Sarah STRONG
  • Mutants of Staphylococcal Mrs and Methods of Use
    Publication number: 20080138835
    Abstract: Mutant bacterial MRS nucleic acids and proteins are provided, as well as uses for the nucleic acids and proteins, such as in a high-throughput screen for inhibitors of the mutant proteins.
    Type: Application
    Filed: May 9, 2005
    Publication date: June 12, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: Ian A. Critchley, Urs Ochsner, James M. Bullard
  • Novel tRNA Synthetase
    Publication number: 20080124313
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Application
    Filed: December 10, 2007
    Publication date: May 29, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: JOHN EDWARD HODGSON, ELIZABETH JANE LAWLOR
  • Enantiomeric Compounds With Antibacterial Activity
    Publication number: 20080108651
    Abstract: Novel compounds in enantiomeric excess that are inhibitors of bacterial methionyl synthetase (MetRS) are disclosed. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, and in particular their use in therapy for Clostridium difficile infection.
    Type: Application
    Filed: September 11, 2007
    Publication date: May 8, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: Joseph GUILES, Xicheng SUN, Nebojsa JANJIC, Sarah STRONG, Albert GYORKOS
  • Methionyl tRNA synthetase polynucleotides
    Patent number: 7361476
    Abstract: The invention provides metS polypeptides and DNA (RNA) encoding metS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 22, 2008
    Assignee: Replidyne, Inc.
    Inventor: Elizabeth Jane Lawlor
  • tRNA synthetase
    Patent number: 7335499
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: February 26, 2008
    Assignee: Replidyne, Inc.
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • tRNA synthetases, metRS
    Publication number: 20070292921
    Abstract: The invention relates to metRS polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing metRS polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: August 2, 2006
    Publication date: December 20, 2007
    Applicant: Replidyne, Inc.
    Inventors: Philip Hayes, Daniel Gentry, Stephanie Van Horn
  • metRS2
    Patent number: 7304152
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: December 4, 2007
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY
    Publication number: 20070213362
    Abstract: A method of inhibiting MetRS activity comprises administering to a patient in need thereof a MetRS inhibiting effective amount of a compound of the formula (I). A method of treating a resistant or multiply-resistant E. faecalis infection, a resistant or multiply-resistant S. aureus infection, and/or a resistant or multiply-resistant S. epidermidis infection comprises administering to a patient in need thereof an antibacterially effective amount of a compound of the formula (I).
    Type: Application
    Filed: May 21, 2007
    Publication date: September 13, 2007
    Applicant: Replidyne, Inc.
    Inventors: John Berge, Andrew Forrest, Dieter Hamprecht, Richard Jarvest
  • Compositions and methods for topical administration of 2-NH-heteroarylimidazoles
    Patent number: 7220757
    Abstract: Compounds of formula (I): are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: May 22, 2007
    Assignee: Replidyne, Inc.
    Inventors: John Berge, Andrew Forrest, Dieter Hamprecht, Richard Jarvest
  • metRS2
    Publication number: 20070009993
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
    Type: Application
    Filed: June 16, 2006
    Publication date: January 11, 2007
    Applicant: Replidyne, Inc.
    Inventors: Daniel Gentry, David Holmes, Karen Ingraham
  • metRS2
    Patent number: 7128920
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham