Patents Assigned to Research Biochemicals Limited Partnership
  • Iodinated neuroprobe for mapping monoamine reuptake sites
    Patent number: 5439666
    Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R=a C.sub.n H.sub.2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including .sup.n F where n=18 or 19, or a .sup.m C.sub.n H.sub.2n+1 group where n=1-6 and where m=11 or 14 for at least one .sup.m C;R'=a C.sub.n H.sub.2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group;X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH.sub.3, or Sn(R".sub.1 R".sub.2 R".sub.3);R".sub.1 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group;R".sub.2 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group;R".sub.3 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; andY=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I.Related analogs are also provided.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: August 8, 1995
    Assignee: Research Biochemicals Limited Partnership
    Inventors: John L. Neumeyer, Richard A. Milius, Robert B. Innis
  • Iodinated neuroprobe for mapping monoamine reuptake sites
    Patent number: 5310912
    Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R=a C.sub.n H.sub.2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including .sup.n F where n=18 or 19, or a .sup.m C.sub.n H.sub.2n+1 group where n=1-6 and where m=11 or 14 for at least one .sup.m C;R'=a C.sub.n H.sub.2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group;X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH.sub.3, or Sn(R".sub.1 R".sub.2 R".sub.3);R".sub.1 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group;R".sub.2 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group;R".sub.3 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; andY=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I.Related analogs are also provided.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: May 10, 1994
    Assignee: Research Biochemicals Limited Partnership
    Inventors: John L. Neumeyer, Richard A. Milius, Robert B. Innis