Abstract: This invention relates to nucleoside and acyclo analogs containing 5- or 6-substituted 2-pyrazinone-4-N-oxide. These compounds are useful for treating various conditions including viral infections, cancer, fungal infections, bacterial infections, microbial infections and related disease states. This invention also relates to pharmaceutical formulations containing these compounds. In addition, this invention relates to methods of treating the above-described conditions in animals and in particular, humans.
Type:
Grant
Filed:
May 30, 1991
Date of Patent:
March 9, 1993
Assignees:
Research Foundation of State of N.Y., Yale University
Inventors:
Yung-Chi Cheng, Tai-Shun Lin, Thomas J. Bardos