Abstract: Disclosed herein are compounds and compositions of formula I that are inhibitors of amino acid transport, specifically alanine serine cysteine transporter 2 (ASCT2): These compounds are useful as therapeutic agents for treating various cancers. Methods for inhibiting an ASCT2 transporter are also disclosed. Certain compounds are selective for an ASCT transporter.

Abstract: Quantum network devices, systems, and methods are provided to enable long-distance transmission of quantum bits (qubits) for applications such as Quantum Key Distribution (QKD), entanglement distribution, and other quantum communication applications. Such systems and methods provide for separately storing first, second, third, and fourth photons, wherein the first and second photons and the third and fourth photons are respective first and second entangled photon pairs, triggering a synchronized retrieval of the stored first, second, third, and fourth photons such that the first photon is propagated to a first node, the second and third photons are propagated to a second node, and the fourth photon is propagated to a third node, and creating a new entangled pair comprising the first and fourth photons at the first and third nodes to transmit quantum information.

Abstract: A method and system for the nitrification and denitrification of septic effluent, e.g. from a domestic septic tank, is disclosed comprising a variable speed pump system for constant continuous flow and a recycle mechanism to increase efficacy in producing a final denitrified effluent suitable for discharge to ground or surface waters.

Abstract: An exemplary system, method, and computer-accessible medium for generating an image(s) of an anatomical structure(s) in a biological sample(s) can include receiving first wide field microscopy imaging information for the biological sample, generating second imaging information by applying a gradient-based distance transform to the first imaging information, and generating the image(s) based on the second imaging information. The second imaging information can be generated by applying an anisotropic diffusion procedure to the first imaging information. The second imaging information can be generated by applying a curvilinear filter and a Hessian-based enhancement filter after the application of the gradient-based distance transform. The second information can be generated by applying (i) a tube enhancement procedure or (ii) a plate enhancement procedure after the application of the gradient-based distance transform.

Abstract: Provided area device for detecting sub-atomic particles and method of fabrication thereof. The device includes a plurality of scintillators, a detector provided on a first end of the plurality of scintillators and a prismatoid provided on a second end of the plurality of scintillators. The prismatoid redirects light between adjacent scintillators of the plurality of scintillators.

Abstract: There is set forth herein an optoelectrical device, comprising: a substrate; an interposer dielectric stack formed on the substrate, the interposer dielectric stack including a base interposer dielectric stack, a photonics device dielectric stack, and a bond layer that integrally bonds the photonics device dielectric stack to the base interposer dielectric stack. There is set forth herein a method comprising building an interposer base structure on a first wafer having a first substrate, including fabricating a plurality of through vias in the first substrate and fabricating within an interposer base dielectric stack formed on the first substrate one or more metallization layers; and building a photonics structure on a second wafer having a second substrate, including fabricating one or more photonics devices within a photonics device dielectric stack formed on the second substrate.

Abstract: The disclosure relates to enhancing alkalinity of brine, e.g. seawater, using bipolar membrane electrodialysis (BPMED) without removing divalent cations that otherwise cause scaling. In one embodiment, a BPMED is employed wherein the brine volumetric flow rate through a basification compartment is greater at a given current density than that through a brine compartment which increases the pH of the brine output while keeping it below the precipitation pH. In one embodiment, the spacer located in the basification compartment is thicker than spacers elsewhere in the BPMED so as resist membrane distortion due to the increased hydrostatic pressure in the basification compartment given the greater volumetric flow. The brine output having increased alkalinity can be returned to the ocean to mitigate acidification and enable capture of atmospheric carbon dioxide.

Abstract: A processing unit and a method of operating a processing unit. In an embodiment, the processing unit comprises a SIMON block cipher for transforming plaintext data into encrypted data. A key expansion module generates and outputs one or more encryption keys; and the key expansion module includes a first series of adiabatic registers for holding key generation data values, and for using adiabatic switching to transmit the key generation data values through the first series of adiabatic registers. A round function module receives the plaintext data and the one or more encryption keys, encrypts the plaintext data to generate the encrypted data, and outputs the encrypted data; and the round function module includes a second series of adiabatic registers for holding encryption data, and for using adiabatic switching to transmit the encryption data through the second series of adiabatic registers.

Abstract: Methods for ultrasonic communications through biological tissue using ultrasonic pulses are disclosed. For example, methods for calculating a forward data generation rate and a forward transmission probability profile for ultrasonic communications through biological material are disclosed. The method may comprise measuring sets interference values corresponding to instants on a communication channel. First and second order moments may be calculated for each instant based on the measured interference values. An outage probability may be calculated for each set and the forward data generation rate and forward transmission probability profile may be calculated based on the outage probability value and other parameters and a threshold transmission rate, a transmission delay threshold, and a residual transmission error rate.

Abstract: The disclosure relates to a method for controlling compression ignition combustion phasing in an internal combustion engine, the method comprising providing a high heat of vaporization fuel charge, the high heat of vaporization fuel charge having a latent heat of vaporization; and directly injecting a spray of the fuel charge into a cylinder of an internal combustion engine during the intake stroke, the internal combustion engine having a gas exchange stage and a combustion stage, the injecting from a single injector and occurring at least immediately after Top Dead Center during the gas exchange stage.

Abstract: A multiplexing scheme for both energy and timing information is provided for a particle detection system having an optical sensor array with multiple optical sensors. Each optical sensor is associated with multiple scintillator modules. The system has a segmented prismatoid light guide comprising multiple prismatoid segments. Each segment is associated with multiple optical sensors, where the optical sensors are adjacent. One end each scintillator module is in contact with its associated optical sensor and the other is in contact with its associated segment. Multiple optical sensors may be connected to an energy readout channel, respectively, such that optical sensors associated with the same segments are not connected to the same energy readout channel. Each energy readout channel has at least two timestamps associated therewith.

Abstract: The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.

Abstract: The present invention provides a compound, and method of selectively inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure:

Abstract: Methods and devices for transmitting and receiving data through biological tissue using ultrasonic pulses are described. Methods of the present invention may set an initial time-hopping frame length and an initial spreading code length for data transmission. A request-to-transmit may be sent from a transmitter over a control channel at the initial frame and code length. The receiver may respond to the transmitter with a clear-to-transmit packet having feedback information. The feedback information can be used to improve a forward time-hopping frame length and a forward spreading code length. Embodiments of the invention may involve a body area network or body surface network comprising a plurality of implanted sensor nodes operating according to the disclosed invention.

Abstract: Presented are RNA nucleotide sequences referred to as EXO-Codes, and longer RNA polynucleotides that contain the EXO-Codes. EXO-Codes provide RNA with the ability to a) be selectively sorted to extracellular vesicles such as exosomes, and b) deliver a variety of cargo types to program or reprogram the extracellular vesicles, and cells that receive the exosomes. Also presented are methods of making the EXO-Codes, modifying cells using the EXO-Codes, expression vectors encoding the EXO-Codes, and exosomes and other secreted vesicles that include RNA polynucleotides that contain the EXO-Codes.

Abstract: Photoresist layers of semiconductor components including electric fields. The photoresist layer may include a body including a first portion disposed directly over a conductive layer of the semiconductor component. The body may also include a second portion integrally formed with and positioned over the first portion. The second portion may include a surface formed opposite the first portion. Additionally, the second portion may include a plurality of charged-particles implanted therein, where the plurality of charged-particles generating an electric field may extend through the first portion and the second portion of the body.

Abstract: A multiplexing scheme, a system for reading out signals from an optical sensor array, particle detection devices and systems are provided. For example, the optical sensor array may comprise plurality of optical sensors arranged in rows and columns. In the multiplexing scheme, a readout ASIC may be electrically connected to the plurality of optical sensors via a plurality of first channels and a plurality of second channels. Each first channel may be electrically connected to a subset of optical sensors in a corresponding row of the optical sensor array, where there may be at least one optical sensor between connections. Each second channel may be electrically connected to a subset of optical sensors in a corresponding column of the optical sensor array, where there may be at least one optical sensor between connections.

Abstract: A multi-hypervisor system, comprising: a plurality of hypervisors comprising a first hypervisor and a second hypervisor, at least one of the plurality of hypervisors being a transient hypervisor; and at least one Span VM, concurrently executing on each of the plurality of hypervisors, the at least one transient hypervisor being adapted to be dynamically at least one of injected and removed under the at least one Span VM concurrently with execution of the at least one Span VM on another hypervisor, wherein the at least one Span VM has a single and consistent at least one of memory space, virtual CPU state, and set of input/output resources, shared by the plurality of hypervisors.

Abstract: Structures operable to detect radiation are described. An imaging system is also described having the structures. For example, a structure may include two screens and a photosensor array between the two screens. One of the screens is comprised of a scintillating glass substrate. The scintillating glass substrate may serve two purposes. The scintillating glass substrate converts incident x-rays into light photons. Additionally, the scintillating glass substrate is a substrate for the photosensor array. The photosensor array is configured to detect light photons that reach the photosensor array from both screens.

Abstract: Various gate all-around field effect transistors (GAAFET) including quantum-based features are disclosed. GAAFET may include a center core including a first end and a second end, a source region positioned circumferentially around the first end of the center core, and a drain region positioned circumferentially around the second end of the center core. The drain region may also be positioned axially opposite the source region. The GAAFET may also include a gate portion axially positioned between the source region and the drain region. The gate portion may include at least one quantum-based feature circumferentially disposed around the center core, and a gate contact circumferentially disposed around the quantum-based feature(s). The quantum-based feature(s) may include a plurality of quantum dots (QD) or at least one quantum well channel.