Patents Assigned to Rhone-Poulenc S.A.
  • Patent number: 4005154
    Abstract: A heat resistant heat-curable polymer composition obtained by reacting, between 50.degree. C. and 350.degree. C., (a) an oligomer having the average general formula: ##STR1## in which x represents a number from 0.1 to about 2, R represents a divalent hydrocarbon radical with 1 to 8 carbon atoms, which is derived from an aldehyde or a ketone of the general formula:O=Rin which the oxygen atom is bonded to a carbon atom of the radical R, and D represents a divalent organic radical possessing 2 to 24 carbon atoms, the free valencies of which are on adjacent carbon atoms and which is derived from an internal anhydride of the general formula: ##STR2## at least 60% of the D radicals in the oligomer containing a polymerizable carbon-carbon double-bond, with (b) a polyamine of the general formula:Q(NH.sub.2).sub.yin which y represents an integer at least equal to 2 and Q represents an organic radical of valency y, the relative amounts being such that the oligomer supplies 1.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: January 25, 1977
    Assignee: Rhone-Poulenc S.A.
    Inventor: Michel Bargain
  • Patent number: 4005212
    Abstract: Imidazo[2,1-b]thiazoles carrying in the 2-position a phenyl radical unsubstituted or substituted by one or two atoms or radicals selected from halogen atoms and alkyl, alkoxy, alkylthio, dialkylamino, dialkylsulphamoyl, nitro, cyano and trifluoromethyl radicals or carrying in the 2-position a 2-, 3- or 4-pyridyl radical unsubstituted or substituted by an alkyl or alkoxy radical, are new compounds possessing pharmacological properties and useful, in particular, as anti-depressants and psycho-energisers.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: January 25, 1977
    Assignee: Rhone-Poulenc S.A.
    Inventors: Francois Debarre, Claude Jeanmart, Pierre Edouard Simon
  • Patent number: 4001271
    Abstract: Isoindolin-1-one derivatives carrying on the nitrogen atom in the 2-position a phenyl or pyridyl radical, optionally carrying one or two substituents selected from halogen, alkyl (C.sub.1 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), cyano and trifluoromethyl, and in the 3-position a grouping --O--T--NR.sub.1 R.sub.2 wherein T is alkylene (C.sub.2 -C.sub.6), and R.sub.1 and R.sub.2 represent hydrogen or alkyl (C.sub.1 -C.sub.4), are new compounds possessing pharmacodynamic properties and are useful as anti-arrhythmic agents.
    Type: Grant
    Filed: February 7, 1974
    Date of Patent: January 4, 1977
    Assignee: Rhone-Poulenc S.A.
    Inventors: Claude Cotrel, Claude Jeanmart, Mayer Naoum Messer
  • Patent number: 4000306
    Abstract: Isoindolin-1-one derivatives carrying on the nitrogen atom in the 2-position a phenyl or pyridyl radical, optionally carrying one or two substituents selected from halogen, alkyl (C.sub.1 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), cyano and trifluoromethyl, and in the 3-position a grouping --O--T--NR.sub.1 R.sub.2 wherein T is alkylene (C.sub.2 -C.sub.6), and R.sub.1 and R.sub.2 represent hydrogen or alkyl (C.sub.1 -C.sub.4), are new compounds possessing pharmacodynamic properties and are useful as anti-arrhythmic agents.
    Type: Grant
    Filed: March 17, 1975
    Date of Patent: December 28, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Claude Cotrel, Claude Jeanmart, Mayer Naoum Messer
  • Patent number: 3998904
    Abstract: Polyamines possessing imide groups are obtained by heating at least one unsaturated polyimide of the general formula: ##STR1## WITH AT LEAST ONE POLYAMINE OF THE GENERAL FORMULA:Z(NH.sub.2).sub.bIn which a and b each independently represents a number ranging from 2 to 6, Y represents an organic radical of valency a and Z represents an organic radical of valency b, in amounts such that the ratio of the number of NH.sub.2 groups introduced by the polyamine to the number of imide groups introduced by the polyimide is greater than 1 and at most equal to 5. These polyamines are useful for curing epoxy resins.
    Type: Grant
    Filed: May 20, 1975
    Date of Patent: December 21, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Maurice Balme, Max Gruffaz
  • Patent number: 3997610
    Abstract: A process is provided for the recovery of citronellal and homologous unsaturated aldehydes from alcohol solutions thereof which comprises adding to the solution a small amount of water and an alkali or alkaline earth salt of a boric acid, and then distilling off the alcohol and recovering the citronellal or homologous unsaturated aldehyde.
    Type: Grant
    Filed: March 20, 1975
    Date of Patent: December 14, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventor: Emile Mourier
  • Patent number: 3997663
    Abstract: The invention provides the novel antibiotic known as daunorubicin (13057 RP) which has a powerful anti-cancer effect and is also an anti-bacterial agent. This antibiotic is a constituent of a mixture of three antibiotics, called 9865 R.P., produced by aerobic culture of one of the strains of Streptomyces, NRRL 3046 and 3045.
    Type: Grant
    Filed: December 11, 1972
    Date of Patent: December 14, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Sylvie Pinnert, Leon Ninet, Jean Preud'Homme
  • Patent number: 3997661
    Abstract: The antibiotic daunorubicin is prepared by aerobically cultivating the microorganism Streptomyces griseus, var. rubidofaciens, DS 32,041 (NRRL 3383), or a daunorubicin-producing mutant thereof, using an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, and separating daunorubicin formed during the culture.
    Type: Grant
    Filed: November 14, 1968
    Date of Patent: December 14, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Denise Mancy, Leon Ninet, Jean Preud'Homme
  • Patent number: 3997662
    Abstract: This invention relates to antibiotics designated 9865 RP, and its three constituents, hereinafter designated 13057 RP, 13213 RP and 13330 RP and their preparation.
    Type: Grant
    Filed: May 16, 1963
    Date of Patent: December 14, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Sylvie Pinnert, Leon Ninet, Jean Preud'Homme
  • Patent number: 3996292
    Abstract: Aliphatic dialdehydes are prepared in good yield from the corresponding acid chlorides by reduction with hydrogen and a palladium catalyst in the presence of a tertiary amide.
    Type: Grant
    Filed: October 7, 1974
    Date of Patent: December 7, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventor: Jean-Pierre Decor
  • Patent number: 3993816
    Abstract: An assembly of hollow fibers for use in fluid treatment apparatus and apparatus incorporating such assemblies, in which a primary frame is provided with a central window defined by edges at least two of the opposite edges being thinned down to form hollows. A web of hollow fibers is placed in the hollows and is secured in place, and the fibers secured to one another, by a mass of hardened resin material in at least one of the hollows.The assemblies are mounted in a container, through which a first fluid is caused to flow, the fluid passing around the fibers and through the windows before leaving the container. The interiors of the hollow fibers are connected to the exterior of the container so that either fluid permeate flows out of the apparatus via the interiors of the fibers or a second fluid is caused to flow through the interiors of the fibers if some form of fluid exchange is desired.
    Type: Grant
    Filed: July 10, 1974
    Date of Patent: November 23, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Jacques Baudet, Michel Rochet, Michel Salmon, Bernard Vogt
  • Patent number: 3992395
    Abstract: Chlorinated phenylhydroxylamines of the formula: ##SPC1##(wherein one of X.sub.1 and X.sub.2 represents chlorine and the other represents hydroxylamino, and Y represents chlorine or a 2-alkyl-1,3,4-oxadiazolin-5-one group attached through the 4-position nitrogen atom) are prepared by the hydrogenation, in the presence of a catalyst based on a metal selected from platinum, palladium, rhodium, ruthenium and nickel, of a nitrophenyl compound of the formula: ##SPC2##(wherein one of X and X' represents chlorine and the other represents nitro, and Y is as hereinbefore defined) and in the presence of a nitrogen-containing organic base, the ratio by weight of the organic base to the nitrophenyl compound being greater than 0.1. The products are inter alia useful as intermediates for the preparation of herbicides.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: November 16, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventor: Joel Le Ludec
  • Patent number: 3990943
    Abstract: A process for the enzymatic isomerization of glucose to fructose where the glucose isomerase is combined with magnesium or magnesium and cobalt ions which have been fixed to a cation exchange resin. The glucose isomerase remains combined with the metal ions during the isomerization. The use of the instant complex prolongs the working life of the enzyme and minimizes the need for conventional pH control.
    Type: Grant
    Filed: September 25, 1974
    Date of Patent: November 9, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Albert Bouniot, Michel Guerineau
  • Patent number: 3989598
    Abstract: The invention provides the novel antibiotic known as daunorubicin (13057 RP) which has a powerful anti-cancer effect and is also an anti-bacterial agent. This antibiotic is a constituent of a mixture of three antibiotics, called 9865 R.P., produced by aerobic culture of one of the strains of Streptomyces, NRRL 3046 and 3045.
    Type: Grant
    Filed: November 21, 1968
    Date of Patent: November 2, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Sylvie Pinnert, Leon Ninet, Jean Preud'Homme
  • Patent number: 3988313
    Abstract: Polysaccharides produced by fermentation are obtained in a non-fibrous form by washing the product produced by precipitation from the fermentation medium with an aqueous organic liquid in which the proportion of organic liquid is high enough to give a washed product which is not soft, difficult to dry and with a tendency to agglomerate, but not so high that the washed product, after drying and grinding, has a fibrous structure, and then drying and grinding the washed polysaccharide.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: October 26, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventor: Albert Bouniot
  • Patent number: 3987167
    Abstract: The antibiotic 20,798 R.P. of the formula: ##SPC1##Is of special interest because of its anti-tumour activity, being particularly active against acute lymphoblastic and myeloblastic leucaemias. The antibiotic is produced by culture of the microorganism Streptomyces coeruleorubidus (NRRL 3045).
    Type: Grant
    Filed: November 22, 1971
    Date of Patent: October 19, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Jean Lunel, Jean Preud'Homme
  • Patent number: 3987028
    Abstract: The antibiotic 20,798 R.P. of the formula: ##SPC1##Is of special interest because of its anti-tumor activity. The antibiotic is produced by culture of the microorganism Streptomyces coeruleorubidus (NRRL 3045).
    Type: Grant
    Filed: March 4, 1969
    Date of Patent: October 19, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Jean Lunel, Jean Preud'Homme
  • Patent number: 3987174
    Abstract: Isoindolin-1-one derivatives substituted on the nitrogen atom in the 2-position by an unsubstituted or substituted phenyl radical or a heterocyclic radical having aromatic characteristics, substituted in the 3-position by a 3-amino(or substituted amino)-2-hydroxy-propoxy group, and optionally substituted in the 5-and/or 6-positions by one or two alkoxy radicals or optionally substituted in the 5- and 6-positions by a methylenedioxy radical, possess pharmacodynamic properties, and are especially useful as anti-arrhythmic agents.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: October 19, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Claude Cotrel, Claude Jeanmart, Mayer Naoum Messer
  • Patent number: 3985134
    Abstract: An extracorporeal blood circuit including a haemodialyser and a pump for pumping blood to and from the haemodialyser, and a single needle for the passage of the blood to and from the body. The single needle is connected to the stem of a Y-shaped coupling, the first branch of which is connected to an inlet pipeline for the pump, an intermediate pipeline connecting the pump to the inlet of the haemodialyser, the outlet of which is connected to the second branch of the Y, a bubble trap being included in the outlet pipeline. A device is provided which seals the inlet and outlet pipelines intermittently and this is driven in a cyclic manner at a predetermined frequency. The haemodialyser and/or the pump and/or the intermediate or outlet pipeline has a variable internal volume which is sensitive to the variations in the differential pressure instantaneously existing between its interior and atmosphere.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: October 12, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Jean Lissot, Andre Sausse
  • Patent number: 3985718
    Abstract: Four component polymerization initiators for olefinic monomers comprise (1) an oxidizing agent such as hydrogen peroxide, a persulphate, a permanganate, a chlorate, a perchlorate, a bichromate, a bromate, a ceric salt, an oxazirane, an organic peroxide or an organic hydroperoxide, (2) a chelate compound of a metal such as titanium, iron, vanadium, aluminum, tin, manganese, chromium, cobalt, copper, zinc or bismuth in which the metal is not fully coordinated, (3) an electron donor in amount at most equal to that required to complex completely the said metal of the chelate compound, the said electron donor being for example an amine, a monoalcohol, an ether, an aldehyde, a ketone, an imine, an oxime, an amide, a sulphonamide, or a phosphonamide, and (4) a chelate complex or salt which is different from the chelate compound (2) and in which the metal may be for example, copper, iron, magnesium, manganese, chromium, vanadium or tin, the degree of coordination of the said metal being different from that of the met
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: October 12, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Henri Chabert, Robert Chapurlat, Claude Gigou, Michel Ruaud