Abstract: Materials and methods related to developing a disease score for a depression disorder (e.g., unipolar depression or major depressive disorder) in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to calculate the score. The materials and methods can be used to, for example, diagnose depression disorders, or determine a subject's predisposition to develop a depression disorder. The methods also can include using a multi-parameter hypermapping system and algorithms related thereto.

Abstract: Materials and methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to measure a plurality of parameters and an algorithm to determine a disease score.

Abstract: Materials and methods for using combinations of metabolic syndrome and HPA axis biomarkers for monitoring major depressive disorder.

Abstract: Optical detection of molecules using a biochip having at least one reagent immobilizing area designed to receive one or more reagents and at least one calibration structure with a predetermined height to provide a height reference for optical measurement is disclosed. When the calibration structure is illuminated by a probe beam of light, a first reflected beam of light is reflected off the calibration structure, and a second reflected beam of light is reflected off the reagent immobilizing area. The first reflected beam and the second reflected beam are compared to determine a height at the reagent immobilizing area.

Abstract: Materials and methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to measure a plurality of parameters and an algorithm to determine a disease score.

Abstract: Materials and methods for using combinations of metabolic syndrome and HPA axis biomarkers for monitoring major depressive disorder.

Abstract: Materials and Methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to measure a plurality of parameters and an algorithm to determine a disease score.

Abstract: Materials and Methods for stratifying disease severity and for monitoring major depressive disorder are provided.

Abstract: Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment. For example, materials and methods for monitoring the effectiveness of vagus nerve stimulation in a subject having a neuropsychiatric disease are provided.

Abstract: Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment. For example, materials and methods for monitoring the effectiveness of transcranial magnetic stimulation in a subject having a neuropsychiatric disease are provided.

Abstract: Materials and Methods related to diagnosing depression disorders, or determining a subject's predisposition to develop a depression disorder, using a multi-parameter hypermapping system and algorithms related thereto.