Abstract: Presented herein are systems and methods related to efficiently hosting one or more computing applications on a server for remote access by a plurality of user computing devices (e.g., personal computers, smart phones, tablet computers, or the like). Applications can be hosted on a server that is part of a distributed (e.g., clustered) computing system. The server can be a physical server or a virtual server (e.g., a cloud-based server). The computing application is executed in a host operating system of the server. The host operating system includes one or more specially designed pattern files, which a processor of the server uses to produce user-specific calls for execution in the hosted computing application. These unique user-specific calls allow a plurality of user devices to efficiently access and operate a single instance of a computing application.