Patents Assigned to RISEN (SUZHOU) PHARMA TECH CO., LTD.
  • Stable heavy isotopes in amide functional groups and uses thereof
    Patent number: 11970490
    Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: April 30, 2024
    Assignees: RISEN (SUZHOU) PHARMA TECH CO., LTD., SHANGHAI JUNSHI BIOSCIENCES CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Xiang Ji, Dongqing Zhu, Xiaolin He, Xianqi Kong
  • Prodrugs of a CDK inhibitor for treating cancers
    Patent number: 11725020
    Abstract: There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glycogen synthase kinase-3 (GSK-3), for the treatment of disease states or conditions mediated by cyclin dependent kinases and/or glycogen synthase kinase-3, including cancers.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: August 15, 2023
    Assignees: RISEN (SUZHOU) PHARMA TECH CO., LTD., SHANGHAI JUNSHl BIOSCIENCES CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Gang Chen, Xiaolin Zhang, Feng Zhou, Xianqi Kong
  • Glucosamine derivatives for the prevention or treatment of joint disorders
    Patent number: 11718636
    Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: August 8, 2023
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Xianqi Kong, Jiasheng Lu, Jiamin Gu, Xiang Ji, Daiqiang Hu, Xiuchun Zhang, Xinyong Lv, Jinchao Ai, Dongdong Wu, Lin Wang, Dongqing Zhu, Xiaolin He
  • Crystalline form of 3-((L-valyl) amino))-3, 3-dideuterium-1-propanesulfonic acid, preparation method and uses thereof
    Patent number: 11608314
    Abstract: The present invention relates to a crystalline form of compound 3-((L-valyl)amino)-3,3-dideuterium-1-propanesulfonic acid, preparation method and uses thereof.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: March 21, 2023
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Daiqiang Hu, Xianqi Kong
  • Glucosamine derivatives and pharmaceutical uses thereof
    Patent number: 11591358
    Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: February 28, 2023
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Xiang Ji, Daiqiang Hu, Xiuchun Zhang, Xinyong Lv, Jinchao Al, Dongdong Wu, Xianqi Kong, Lin Wang, Dongqing Zhu, Xiaolin He
  • CD73 inhibitors and pharmaceutical uses thereof
    Patent number: 11530234
    Abstract: CD73 (also known as ecto-5?-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I and pharmaceutically acceptable esters or salts thereof.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: December 20, 2022
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Gang Chen, Feng Zhou, Qiguo Zhang, Xuli Wang, Xiang Ji, Lin Wang, Xianqi Kong
  • Prodrugs of a CDK inhibitor for treating cancers
    Patent number: 11225497
    Abstract: There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glycogen synthase kinase-3 (GSK-3), for the treatment of disease states or conditions mediated by cyclin dependent kinases and/or glycogen synthase kinase-3, including cancers.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: January 18, 2022
    Assignees: RISEN (SUZHOU) PHARMA TECH CO., LTD., SHANGHAI JUNSHI BIOSCIENCES CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Gang Chen, Xiaolin Zhang, Feng Zhou, Xianqi Kong
  • Crystalline form of 3-((L-valyl)amino))-3,3-dideuterium-1-propanesulfonic acid, preparation method and uses thereof
    Patent number: 11186543
    Abstract: The present invention relates to a crystalline form of compound 3-((L-valyl)amino)-3,3-dideuterium-1-propanesulfonic acid, preparation method and uses thereof.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: November 30, 2021
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Daiqiang Hu, Xianqi Kong
  • Isotope-enriched 3-amino-1-propanesulfonic acid derivatives and uses thereof
    Patent number: 10954188
    Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: March 23, 2021
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Xinyong Lv, Guowei Song, Dongdong Wu, Daiqiang Hu, Jun Gu, Gang Chen, Xiang Ji, Xiuchun Zhang, Jinchao Ai, Xianqi Kong
  • CD73 inhibitors and pharmaceutical uses thereof
    Patent number: 10881681
    Abstract: CD73 (also known as ecto-5?-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I and pharmaceutically acceptable esters or salts thereof.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: January 5, 2021
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Dongdong Wu, Gang Chen, Chengyong Sun, Xiang Ji, Lin Wang, Feng Zhou, Xiuchun Zhang, Xianqi Kong
  • Isotope-enriched 3-amino-1-propanesulfonic acid derivatives and uses thereof
    Patent number: 10472323
    Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 12, 2019
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Xinyong Lv, Guowei Song, Dongdong Wu, Daiqiang Hu, Jun Gu, Gang Chen, Xiang Ji, Xiuchun Zhang, Jinchao Ai, Xianqi Kong