Abstract: Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L)??j1; Ru(E)(E?)(L)(D)??j2; wherein m, n, Ar, Y, R1 E, E?, D, Z and L are as defined herein.
Type:
Grant
Filed:
December 14, 2009
Date of Patent:
February 21, 2012
Assignee:
Roche Palo Alto LLP
Inventors:
Kieran Durkin, Lawrence Emerson Fisher, Arthur Meili, Michaelangelo Scalone, Xianqing Shi, Justin Vitale
Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
Type:
Grant
Filed:
December 12, 2009
Date of Patent:
February 21, 2012
Assignee:
Roche Palo Alto LLP
Inventors:
Li Chen, Lichun Feng, Minmin Yang, Michael Patrick Dillon, Yingjie Lai