Patents Assigned to Roche Vitamins Inc.
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Patent number: 6586202Abstract: The present invention relates to an isolated DNA sequence encoding an enzyme in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate. Vectors and plasmids including such DNA are also set forth. The invention also includes host cells transformed by such DNAs, or vectors or plasmids containing such DNAs. A process for the production of isoprenoids and carotenoids using such transformed host cells is also provided.Type: GrantFiled: August 9, 2001Date of Patent: July 1, 2003Assignee: Roche Vitamins, Inc.Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
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Patent number: 6579975Abstract: A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins.Type: GrantFiled: August 8, 2000Date of Patent: June 17, 2003Assignee: Roche Vitamins, Inc.Inventor: Martin Lehmann
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Publication number: 20030105160Abstract: A process for producing L-ascorbic acid or D-erythorbic acid, or in each case its sodium, potassium or calcium salt, from 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, or in each case its sodium, potassium or calcium salt, that involves incubating 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, each as the free acid or as its sodium, potassium or calcium salt, and the cells of a thermoacidophilic microorganism at temperatures from about 30° C. to about 100° C., and at a pH from about 1 to about 6, in a solution, to form L-ascorbic acid or D-erythorbic acid or an appropriate salt thereof, and isolating said product from the solution.Type: ApplicationFiled: August 23, 2001Publication date: June 5, 2003Applicant: ROCHE VITAMINS INC.Inventors: Akira Asakura, Tatsuo Hoshino, Masako Shinjoh
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Patent number: 6573269Abstract: The present invention provides compounds of formula I, which are effective in absorbing ultraviolet radiation and can be used as sunscreen agents: wherein R1 and R2 are each independently C2-C18 alkyl, C5-C7 cycloalkyl, or C2-C18 alkyl in which at least one methylene group is replaced by oxygen; R3 is hydrogen, C1-C18 alkyl, C2-C18 alkyl in which at least one methylene group is replaced by oxygen, C1-C18 alkyl carbonyl, C3-C18 alkenyl, C3-C18 alkynyl, or a group YS; R4 is hydrogen, C1-C8 alkyl or a group OR3; Y is a linker group; and S is a silane-, an oligosiloxane- or a polysiloxane-moiety.Type: GrantFiled: September 1, 2000Date of Patent: June 3, 2003Assignee: Roche Vitamins Inc.Inventor: Ulrich Huber
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Publication number: 20030096382Abstract: The present invention provides process for making biotin from desthiobiotin either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product and/or nifS gene product and isolating the biotin or cultivating a microorganism transformed with DNA encoding the bioB gene product, nifU gene product and nifS gene product and isolating the biotin.Type: ApplicationFiled: March 22, 2001Publication date: May 22, 2003Applicant: ROCHE VITAMINS INC.Inventors: Tatsuo Hoshino, Akira Asakura, Tatsuya Kiyasu, Yoshie Nagahashi
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Publication number: 20030092155Abstract: A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.Type: ApplicationFiled: February 1, 2002Publication date: May 15, 2003Applicant: ROCHE VITAMINS INC.Inventors: Dirk Kostrewa, Luis Pasamontes, Andrea Tomschy, Adolphus van Loon, Kurt Vogel, Markus Wyss
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Publication number: 20030083270Abstract: A process is provided for making (-)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regenerating the resin by desorbing the remaining catechins, and optionally concentrating the desorbed catechins.Type: ApplicationFiled: September 18, 2002Publication date: May 1, 2003Applicant: ROCHE VITAMINS, INC.Inventors: David Carl Burdick, Heinz Egger, Andrew George Gum, Ingo Koschinski, Elena Muelchi, Isabelle Prevot-Halter
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Publication number: 20030077691Abstract: The present invention is directed to genetic materials useful for the preparation of astaxanthin from beta-carotene, such as polypeptides having astaxanthin synthase activity, DNA fragments coding for astaxanthin synthase, recombinant organisms and the like. Those novel genetic materials may be derived from Phaffia rhodozyma. The present invention also provides a process for the production of astaxanthin.Type: ApplicationFiled: February 1, 2002Publication date: April 24, 2003Applicant: ROCHE VITAMINS INC.Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
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Patent number: 6551813Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.Type: GrantFiled: May 6, 1999Date of Patent: April 22, 2003Assignee: Roche Vitamins Inc.Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
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Patent number: 6536940Abstract: A process for mixing or dispersing liquids is provided that includes introducing liquids to be mixed or dispersed into a mixing device having a cylindrical support. The cylindrical support includes an inlet nozzle having a bore which is in fluid communication through a turbulence chamber with a bore of an outlet nozzle, wherein the bores of the nozzles are axially spaced apart relative to one another. The liquids are then allowed to enter the turbulence chamber through the bore of the inlet nozzle where the liquids are mixed or dispersed. The mixed or dispersed liquid is then recovered from the outlet nozzle. Various devices for mixing or dispersing liquids are also provided.Type: GrantFiled: June 18, 2002Date of Patent: March 25, 2003Assignee: Roche Vitamins Inc.Inventors: Gudrun Kolb, Hermann Stein, Klaus Viardot
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Publication number: 20030053372Abstract: A process for mixing or dispersing liquids is provided that includes introducing liquids to be mixed or dispersed into a mixing device having a cylindrical support. The cylindrical support includes an inlet nozzle having a bore which is in fluid communication through a turbulence chamber with a bore of an outlet nozzle, wherein the bores of the nozzles are axially spaced apart relative to one another. The liquids are then allowed to enter the turbulence chamber through the bore of the inlet nozzle where the liquids are mixed or dispersed. The mixed or dispersed liquid is then recovered from the outlet nozzle. Various devices for mixing or dispersing liquids are also provided.Type: ApplicationFiled: June 18, 2002Publication date: March 20, 2003Applicant: ROCHE VITAMINS INC.Inventors: Gudrun Kolb, Hermann Stein, Klaus Viardot
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Publication number: 20030054523Abstract: The present invention relates to an isolated DNA sequence encoding an enzyme in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate. Vectors and plasmids including such DNA are also set forth. The invention also includes host cells transformed by such DNAs, or vectors or plasmids containing such DNAs. A process for the production of isoprenoids and carotenoids using such transformed host cells is also provided.Type: ApplicationFiled: August 9, 2001Publication date: March 20, 2003Applicant: ROCHE VITAMINS INC.Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
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Patent number: 6534297Abstract: The present invention is directed to genetic material useful for the preparation of actinol, such as an isolated DNA including a nucleotide sequence coding for an enzyme having levodione reductase activity, a polypeptide encoded by such a DNA, recombinant organisms, and the like. These genetic materials may originate from Corynebacterium, Cellulomonas, Planococcus, Arthrobacter, and the like. The present invention also provides a process for the production of actinol.Type: GrantFiled: January 31, 2001Date of Patent: March 18, 2003Assignee: Roche Vitamins, Inc.Inventors: Sakayu Shimizu, Masaru Wada
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Publication number: 20030049720Abstract: A process for producing carotenoids, which involves cultivating a microorganism obtained by treating a parent microorganism that produces carotenoids under conditions that induce a reduction in alternative oxidase activity and selecting a microorganism with enhanced carotenoid productivity, a method for obtaining the microorganism with enhanced carotenoid productivity, and the microorganism itself.Type: ApplicationFiled: May 24, 2001Publication date: March 13, 2003Applicant: Roche Vitamins Inc.Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
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Patent number: 6530684Abstract: A process for mixing or dispersing liquids is provided that includes introducing liquids to be mixed or dispersed into a mixing device having a cylindrical support. The cylindrical support includes an inlet nozzle having a bore which is in fluid communication through a turbulence chamber with a bore of an outlet nozzle, wherein the bores of the nozzles are axially spaced apart relative to one another. The liquids are then allowed to enter the turbulence chamber through the bore of the inlet nozzle where the liquids are mixed or dispersed. The mixed or dispersed liquid is then recovered from the outlet nozzle. Various devices for mixing or dispersing liquids are also provided.Type: GrantFiled: December 6, 1999Date of Patent: March 11, 2003Assignee: Roche Vitamins Inc.Inventors: Gudrun Kolb, Hermann Stein, Klaus Viardot
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Patent number: 6528025Abstract: A process for the preparation of acetals and ketals by reacting an aldehyde or Ketone with an alcohol in the presence of solid acid and removing water by pervaporation. Manufacturing equipment for the preparation of acetals and ketones is also provided.Type: GrantFiled: June 29, 2000Date of Patent: March 4, 2003Assignee: Roche Vitamins Inc.Inventors: Volkmar Boesch, Juan Ramon Herguijuela
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Patent number: 6521564Abstract: A process for the modification of a hydrogenation catalyst of the Raney nickel, Raney cobalt, nickel-on-carrier or cobalt-on-carrier type, which process includes treating the hydrogenation catalyst at temperatures of about 0° C. to about 120° C. with carbon monoxide, carbon dioxide, formaldehyde, a lower aliphatic aldehyde, an aromatic aldehyde, an aliphatic ketone, an aromatic ketone, a mixed aliphatic/aromatic ketone, glyoxal, pyruvaldehyde or glyoxylic acid as the modification agent in a liquid dispersion medium consisting of water or an organic solvent for a duration of about 15 minutes to about 24 hours. When the thus-modified catalyst is used in the hydrogenation of a nitrile to the corresponding amine, the selectivity is increased, and significantly favors the amount of the primary amine vis-à-vis the undesired secondary amine in the hydrogenation product as compared to when the corresponding unmodified catalyst is employed.Type: GrantFiled: November 30, 2000Date of Patent: February 18, 2003Assignee: Roche Vitamins, Inc.Inventors: Oliver Gerald Degischer, Felix Roessler
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Publication number: 20030022273Abstract: Novel proteins of microorganism E-396 (FERM BP-4283) and the DNA sequences which encode these proteins have been discovered to provide an improved biosynthetic pathway from farnesyl pyrophosphate and isopentyl pyrophosphate to various carotenoids, especially zeaxanthin, astaxanthin, adonixanthin and canthaxanthin.Type: ApplicationFiled: August 2, 2001Publication date: January 30, 2003Applicant: ROCHE VITAMINS INC.Inventors: Luis Pasamontes, Yuri Tsygankov
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Patent number: 6489486Abstract: The present invention relates to a process for the manufacture of compounds of Formula (I): wherein R1 is alkyl; R2, R3, R4, R5 and R6 are, independently, hydrogen, alkyl or alkenyl; X is hydrogen, halogen, alkyl or alkoxy; and the dotted bond is an optional bond. The present invention also relates to novel light screening compositions containing certain of the compounds of Formula (I) and to certain novel compounds of Formula (I), as well as other novel 2-substituted phenyl-benzotriazole compounds.Type: GrantFiled: January 18, 2001Date of Patent: December 3, 2002Assignee: Roche Vitamins Inc.Inventor: Ulrich Huber
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Patent number: 6482961Abstract: The present invention is a method of making (all-rac)-&agr;-tocopherol in a reaction having the following steps: a) reacting trimethylhydroquinone and a phytol selected from the group consisting of isophytol and phytol in the presence of a bis(perfluorinated hydrocarbyl sulphonyl)imide catalyst or a metal salt thereof of formula I: [(R1SO2)2N]xR2 (I) wherein each R1, independently, signifies a perfluoroalkyl group CnF2n+1 or a pentafluorophenyl, or both symbols R1 together signify a poly-difluoromethylene group—(CF2)m—, with the proviso that both symbols R1 cannot simultaneously signify trifluoromethyl, R2 signifies a proton or a cationic form of a metal selected from the group consisting of boron, magnesium, aluminum, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, praseodymium, neodymium, europium, dysprosium, thulium, ytterbium, hafnium, platinum, anType: GrantFiled: August 16, 2001Date of Patent: November 19, 2002Assignee: Roche Vitamins Inc.Inventors: Werner Bonrath, Alois Haas, Eike Hoppmann, Horst Pauling