Abstract: An highly specific and sensitive approach to detecting antibodies to collagen in a biological sample entails contacting the sample with an antigen that comprises the CB10 peptide of mammalian type II collagen, or with an antibody-binding fragment of that peptide, under conditions conducive to formation of an antibody-antigen complex, which then is detected.
Type:
Application
Filed:
February 9, 2004
Publication date:
August 12, 2004
Applicants:
MONTECH MEDICAL DEVELOPMENTS PTY. LTD., RONDOLE PTY. LTD.
Inventors:
Andrew Cook, Merrill Rowley, Ian Mackay
Abstract: A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the CB10 peptide of mammalian type II collagen, or an antibody-binding fragment or variant thereof, for a time and under conditions for an antibody-antigen complex to form, and detecting the antibody-antigen complex, for example by immunoassay. A diagnostic test kit is also disclosed.
Type:
Grant
Filed:
November 20, 2000
Date of Patent:
March 16, 2004
Assignees:
Montech Medical Developments Pty. Ltd., Rondole Pty. Ltd.
Inventors:
Andrew Cook, Merrill Rowley, Ian Mackay
Abstract: An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal moiety derived from the GAD65 isoform, and production thereof as a recombinant protein by expression in eukaryotic host cells, particularly yeasts.
Type:
Grant
Filed:
September 13, 1999
Date of Patent:
December 26, 2000
Assignees:
Montech Medical Developments Pty. Ltd., Rondole Pty. Ltd.
Inventors:
Ian Reay Mackay, Merrill Joy Rowley, Paul Zev Zimmet, Brian Corner, Ruby Law, Khay-Lin Teoh