Patent number: 4868193
Abstract: Compounds of the formula: ##STR1## and salts thereof, wherein,Ar.sub.1 is phenyl, naphthyl or heterocyclic ring selected from the group consisting of quinolinyl, isoquinolinyl, pyridinyl, quinazolinyl, quinoxalinyl, benzimidazolyl, 1,2,3,4-tetrahydroquinolinyl or 1,2,3,4-tetrahydroquinoxalinyl;R.sub.1 is hydrogen, alkyl, carboxy, carbalkoxy, alkanoyl, formyl, nitrilo, amino, halo, CF.sub.3, hydroxy, alkoxy, aralkoxy, aryloxy, nitro, sulfanyl, mercapto or alkylthio;R.sub.2 is hydrogen, alkyl or Ar.sub.1,n is 1 or 2X is O, S, or NH--Y is a bond, methylene or ethyleneR.sub.3 and R.sub.4 are independently hydrogen, alkyl or haloAr is phenyl, naphthyl, pyridyl or quinolinyl containing one or two substituents selected from the group consisting of hydrogen, alkoxy, aryloxy, hydroxy, hydroxyalkyl, alkyl, aryl, halo, CF.sub.3, carboxy, carbalkoxy, lower acyl, nitrilo, amino, nitro, mercapto or alkylthio possess anti-inflammatory and anti-allergic activities.
Type:
Grant
Filed:
September 24, 1986
Date of Patent:
September 19, 1989
Assignee:
Rorer Pharmaceutical Corporation
Inventor:
Thomas D. Y. Lee
Patent number: 4859672
Abstract: Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure ##STR1## wherein: A is ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8, R.sub.10, R.sub.11, R.sub.12, R.sub.14, R.sub.15, R.sub.16, R.sub.17, R.sub.18, R.sub.19, R.sub.20, R.sub.21, R.sub.22, R.sub.23 and R.sub.24 are H, lower alkyl of 1-4 carbon atoms, phenyl, substituted phenyl, phenyl lower alkyl of 1-4 carbon atoms or substituted phenyl lower alkyl of 1-4 carbon atoms;wherein the substituted phenyl group is substituted by one or more of lower alkyl, lower alkoxy, amino, lower alkyl amino, lower alkyl mercapto, hydroxy, hydroxy lower alkyl, acetoxy, benzyloxy, phenoxy, lower alkyl sulfinyl or lower alkyl sulfonyl;R.sub.
Type:
Grant
Filed:
October 29, 1986
Date of Patent:
August 22, 1989
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Alfred P. Spada, Henry F. Campbell, Donald E. Kuhla, William L. Studt, William C. Faith, Bruce F. Molino