Abstract: The present disclosure relates in part to methods of treating, preventing, and/or ameliorating SARS-CoV-2 infection and/or related inflammatory syndromes by administration of a Maackia amurensis seed lectin (MASL). MASL has a strong affinity for sialic acid modified proteins and may be used as an antiviral agent. This lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients.

Abstract: The present invention relates to the unexpected discovery of novel monomer compounds capable of crosslinking interpenetrating polymer networks (IPNs). In certain embodiments, the monomer compounds of the invention each comprise at least one methacrylate functionality capable of forming polymeric bonds with other methacrylate and vinyl functionalities, and at least one epoxide functionality capable of forming polymeric bonds with epoxide functionalities, amine functionalities, and/or reactive oxygen species.

Abstract: The present disclosure is directed to methods and kits for using serum biomarkers, including C-X-C Motif Chemokine Ligand 10 (CXCL10), C-X-C Motif Chemokine Ligand 13 (CXCL13), and/or soluble CD27 (sCD27), in predicting and evaluating therapeutic response to Tumor Necrosis Factor (TNF) inhibitor therapy in a patient in need thereof.

Abstract: In one aspect, the present invention relates to thermo-reversible hydrogel drug delivery compositions comprising at least one biodegradable copolymer drug carrier. In certain embodiments, the hydrogel compositions of the invention are optically clear and suitable for use in local delivery of ocular therapeutics. In other embodiments, the hydrogel compositions of the invention provide a means for controlled or sustained drug delivery.

Abstract: The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.

Abstract: The present invention relates in part to a polymer functionalized with a bio-ionic liquid to form a gel electrolyte. The gel electrolyte thus formed is biocompatible and biodegradable. In certain embodiments, the electrolyte is used for making implantable 3D printed energy storage devices.

Abstract: An impact shield for earthquake protection is described herein. The impact shield may include a canopy constructed of a puncture-resistant material, the canopy defining a first internal volume accessible via a first opening, the canopy being structured to form a semispherical shape when in an inflated state, the semispherical shape defining a space dimensioned for sheltering at least one human body; a support joined to the canopy and constructed of the puncture-resistant material, the support defining a second internal volume accessible via the first opening and a second opening, the support located within the space, the support structured to form a column when in the inflated state; and a fitting joined to the support for closing the second opening to fix the first internal volume and the second internal volume after inflation of the support and the canopy.

Abstract: The invention relates to non-woven protein fibers and to methods for forming and producing the same. In certain embodiments, the invention provides a method of processing a protein comprising dissolving a protein in a solution, optionally removing any insoluble materials from the solution, and spraying the solution under an applied pressure. In other embodiments, the protein can be derived from a range of sources, including but not limited to arthropod silks, animal keratin (e.g. hair and wool), tissue elastin, collagen, resilin, and plant protein. In certain embodiments, the methods of the invention are an alternative to electrospinning methods known in the art.

Abstract: Methods and systems for digitally reconstructing a patient tissue sample are described herein. In one embodiment, the method may include projecting a first structured light pattern onto the patient tissue sample, receiving a first reflection of the first structured light pattern from the patient tissue sample, and reconstructing the patient tissue sample based on the first reflection and the projected first structured light pattern. In another embodiment, the system may include a projector adapted or configured to project the first structured light onto the patient tissue sample, a charge-coupled device (CCD) adapted or configured to receive the first reflection from the patient tissue sample, and a reconstruction device adapted or configured to reconstruct the patient tissue sample based on the first reflection and the projected first structured light pattern.

Abstract: The present invention provides a data collection system comprising: a camera; a location module; a plurality of sensors; and a first processor communicatively coupled to the camera and the location module, the first processor programmed to: obtain a plurality of frames from the camera; obtain a plurality of locations from the location module; obtain a plurality of data measurements from the plurality of sensors; apply a previously trained first neural network model for identifying problematic road segments to frames captured by the camera; and if the first neural network model indicates that a frame is a problematic road segment, save the frame in association with a location provided by the location module.

Abstract: Systems and methods for detecting aortic aneurysms using ensemble based deep learning techniques that utilize numerous computed tomography (CT) scans collected from numerous de-identified patients in a database. The system includes software that automates the analysis of a series of CT scans as input (in DICOM file format) and provides output in two dimensions: (1) ranking CT scans by risks of adverse events from aortic aneurysm, (2) providing aortic aneurysm size estimates. A repository of CT scans may be used for training of deep neural networks and additional data may be drawn from localized patient information from institutions and hospitals which grant permission.

Abstract: The present invention provides compositions and methods for treating, ameliorating, and/or preventing cocaine addiction in a subject. Immunization by M. vaccae alters serotonin signaling in the brain, reducing stress- and anxiety-like responding in animal models of post-traumatic stress disorder and other anxiety disorders. In certain embodiments, the immunoregulatory, anti-stress, and anxiolytic effects of M. vaccae immunization reduces addiction- and relapse-like responding in models of cocaine addiction and alter the development of cocaine-induced neuroinflammation.

Abstract: The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.

Abstract: A surgical robot includes a fixed frame and a moving frame, each having an open space in a center region and may be formed as a partially open ring. The robot also includes three leg structures connecting the fixed frame and the moving frame, and enabling the moving frame to move relative to the fixed frame. The robot also includes a stabilizer for holding an anatomical structure in the open space of each frame. Each leg structure may include a linear component coupled to the moving frame, a rotary component mounted to the fixed frame, and a connector connecting between the two. Each of the linear component and the rotary component may have a rotary actuator that can be controlled by a computer. The robot may be controllable by a computer to assist a reduction procedure of long bone fractures or pelvis surgery.

Abstract: The present invention relates to novel biocompatible oxygen gas generating devices that can be implanted into a living subject. In certain embodiments, the oxygen gas generating devices can be used to deliver oxygen gas to tissue in a subject, thereby stimulating tissue growth and repair. In other embodiments, the devices operate by electrolytically splitting endogenous water in a subject. In yet other embodiments, the device further comprises an implantable supercapacitor capable of supplying energy to the oxygen gas generating device.

Abstract: The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

Abstract: This invention relates to the detection and quantification of D-dimer levels in a sample derived from a patient having or suspected of having periprosthetic joint infection (PJI) and subsequent diagnosis of PJI.

Abstract: A composition of matter including two optionally substituted phenol or optionally substituted aniline units separated by a furan spacer has been prepared. In particular, the chemical structure has a novolac bridge between the central furan ring and the two attached optionally substituted phenol and/or optionally substituted aniline units. These compounds can be modified to be used in various polymer resins. This new structure reduces toxicity relative to BPA/F, makes use of renewable chemicals, and produces certain beneficial polymer properties.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.