Abstract: Compounds are provided for use in the diagnosis and/or therapy of tumors and/or as immunosuppressive agent. The compounds are antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred compound is monoclonal antibody MR-6 produced by the hybridoma deposited at the European Collection of Animal Cell Cultures with the accession number 88033002. The invention also extends to the use of the compounds for in vitro removal of graft-versus-host reactive T-lymphocytes prior to bone marrow transplantation and to a novel protein of molecular weight 200,000 daltons functioning as a receptor for IL-4.

Abstract: The invention provides compounds for use in the diagnosis and/or therapy of tumors and/or as an immunosuppressant agent selected from the group consisting of antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred such compound is monoclonal antibody MR6 produced by the hybridoma deposited at the European Collection of Animal Cell Cultures with the accession number 88033002. The invention also extends to the use of the compounds for in vitro removal of graft-versus-host reactive T-lymphocytes prior to bone marrow transplantation and to a novel protein of molecular weight 200,000 daltons functioning as a receptor for IL-4.

Abstract: Apparatus for the in situ hybridization of slide-mounted cell samples contains modules for the three processes required: (a) reagent metering and spreading on a slide (1) which is effected by drawing a quantity of reagent (56-59) into a reservoir (31) and then spraying it on the slide (1) using air pressure. The rate of flow through the spray is ascertained by measurement and the dosage determined by timing the spraying; (b) slide washing; and (c) slide incubation. The slide washing and incubation are performed in the same dual-purpose housing (16). A high humidity level is maintained in the housing during incubation so that the samples do not need to be covered to prevent them drying out. A plurality of slides (1) are mounted in a carrier (11) to be washed and incubated at the same time.

Abstract: A method and apparatus for analyzing an electro-encephalogram (EEG) are described. EEGs from the left and right sides of the head are analyzed substantially simultaneously by detecting bursts of activity having amplitudes which exceed a threshold voltage. Each burst of activity is determined to have ended, i.e. the amplitude is below the threshold voltage, when it is followed by a quiescent interval having a duration of, for example, at least six seconds. The total time of all quiescent intervals occurring within a time period, e.g. ten minutes, is then calculated and displayed. The apparatus includes a digital computer for effecting statistical analysis of total times for many consecutive time periods. The computer may also be used in generating total times. A graphical output representing total times may be generated allowing rapid access of patient progress.