Abstract: The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide a chiral polymeric salen catalyst and its use for producing chiral compounds such as chiral epoxides and chiral 1,2-diols economically in high yield and high optical purity by performing stereoselective hydrolysis or racemic epoxides.
Type:
Grant
Filed:
December 7, 2001
Date of Patent:
June 7, 2005
Assignee:
Rstech Co., Ltd.
Inventors:
Geon-Joong Kim, Dae-Woon Park, Ho Seong Lee, Seong Jin Kim
Abstract: The present invention relates to a process for preparing (−)-(18-crown-6)-2,3,11,12-tetracarboxylic acid and its use for (−)-chiral stationary phases for resolution of racemic compounds. More particularly, the present invention relates to the process for preparing (−)-(18-crown-6)-2,3,11,12-tetracarboxylic acid expressed by formula (1) and the use thereof as a stationary phases for resolution of racemic compounds, wherein the use of them provides excellent separation of a desired chiral compound from racemic mixture in employing capillary electrophoresis (CE) or liquid chromatography to elute the desired one first by controlling a flowing order of enantioners, thus allowing to be consistently separated in an economical due to much less requirement of eluent, quantitative and high purity manner.
Type:
Grant
Filed:
May 22, 2003
Date of Patent:
November 16, 2004
Assignee:
Rstech Co., Ltd.
Inventors:
Ho Seong Lee, Chang Soo Lee, Jin Won Yun, Seong Jin Kim, Kyung-Hyun Gahm
Abstract: The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide chiral salen catalysts and its use for producing chiral compounds such as chiral epoxides and chiral 1,2-diols economically in high yield and high optical purity by performing stereoselective hydrolysis of racemic epoxides, wherein the chiral salen catalyst comprises a cationic cobalt as a center metal of chiral salen ligand and counterions having weak nucleophilic property to resolve disadvantages associated with conventional chiral salen catalysts, and can be used continuously without any activating process of used catalysts because it does not loose a catalytic activity during the reaction process.
Type:
Grant
Filed:
July 11, 2002
Date of Patent:
April 13, 2004
Assignee:
RSTECH Co., Ltd.
Inventors:
Geon-Joong Kim, Dae-Woon Park, Ho Seong Lee, Jin Won Yun, Seong Jin Kim