Abstract: The invention relates to BODIPY derivatives of Formula (I): that bear one or more functional groups which in the photochemical reaction upon irradiation with visible light undergo deamination and deliver quinone methides. Furthermore, the invention relates to the antiproliferative activity of BODIPY derivatives and their use for pharmaceutical applications and for fluorescent labeling, particularly for labeling proteins.

Abstract: The invention relates to BODIPY derivatives of Formula (I): that bear one or more functional groups which in the photochemical reaction upon irradiation with visible light undergo deamination and deliver quinone methides. Furthermore, the invention relates to the antiproliferative activity of BODIPY derivatives and their use for pharmaceutical applications and for fluorescent labeling, particularly for labeling proteins.

Abstract: The present invention relates to the composition with gelling properties comprising low molecular weight gelators of Formula (1) or a salt thereof and a vegetable oil. Uses of such composition in the food, cosmetic or pharmaceutical industry are disclosed.

Abstract: The present invention relates to the novel compounds represented by Formula (Ia) or (Ib) and to their pharmaceutical preparations for the treatment of atherosclerosis and cholesterol level reduction.

Abstract: Present invention refers to a novel and improved method of derivatization and detection of amino acid sequence and/or identification of proteins, peptides by a new derivatization compound. Precisely, the method discloses a novel approach to derivatization of peptides or proteins by compounds comprising two or more sulfonyl groups and analysis of derivatized analytes in negative mode of operation of mass spectrometer. This method allows unambiguous analysis of amino acid sequence of long-chain peptides/proteins. Also, the invention discloses a novel synthesis procedure of 5-formyl-benzene-1,3-disulphonic acid as derivatization compound.

Abstract: The present invention relates to the novel compounds represented by Formula (Ia) or (Ib) and to their pharmaceutical preparations for the treatment of atherosclerosis and cholesterol level reduction.

Abstract: The invention relates to a computing device-implemented method and apparatus for unsupervised segmentation of microscopic color image of unstained specimen and digital staining of segmented histological structures. Image of unstained specimen is created by light microscope 101, recorded by color camera 102 and stored on computer-readable medium 103. The invention is carried out by a computing device 104 comprised of: computer-readable medium for storing and computer for executing instructions of the algorithm for unsupervised segmentation of microscopic color image of unstained specimen and digital staining of segmented histological structures. Segmented histological structures and digitally stained image are stored and displayed on the output storing and display device 105 in order to establish diagnosis of a disease.

Abstract: The present invention relates to a computer-implemented method and apparatus for data processing for the purpose of blind separation of nonnegative correlated pure components from smaller number of nonlinear mixtures of mass spectra. More specific, the invention relates to preprocessing of recorded matrix of mixtures spectra by robust principal component analysis, trimmed thresholding, hard thresholding and soft thresholding; empirical kernel map-based nonlinear mappings of preprocessed matrix of mixtures mass spectra into reproducible kernel Hilbert space and linear sparseness and nonnegativity constrained factorization of mapped matrices therein. Thereby, preprocessing of recorded matrix of mixtures mass spectra is performed to suppress higher order monomials of the pure components that are induced by nonlinear mixtures. Components separated by each factorization are correlated with the ones stored in the library.

Abstract: The compounds of general formula (I) wherein: R1 is hydrogen, phenyl, C1-6 alkyl which can be further substituted with R3, R3 is 5- or 6-membered aromatic or heteroaromatic ring system which can be further substituted with benzyl or hydroxyl groups; R2 is OR4, NHR4, R4 is hydrogen, C1-6 alkyl or benzyl n is an integer from 1 to 12 or the salts of compounds mentioned which can form gels with commercial fuels, organic solvents and water.

Abstract: The invention relates to adamantane diaza-crown ether derivatives and the use of mono and diaza-crown ether adamantine derivatives in treatment, especially in tumor treatment. Adamantane aza-crown ethers were obtained by reaction of the corresponding adamantane derived tosylates or adamantane acid chlorides with mono- and diaza-18-crown-6. The prepared compounds showed moderate (monoaza-18-crown-6) to strong (diaza-18-crown-6) antiproliferative and cytotoxic activity on several tumor cell lines, revealing their potential for inhibiting the growth of other tumor cells.

Abstract: The present invention refers to analogues of 1,3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for the treatment of different types of tumors. Said compounds show cytotoxicity at very low concentrations (IC50 0.22 to 12.8 ?M), and good solubility. These compounds can be used in the treatment of tumor patients as single drugs or in combination with other cytostatics.

Abstract: New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.

Abstract: A computer-implemented data processing system for blind extraction of more pure components than mixtures recorded in 1D or 2D NMR spectroscopy and mass spectrometry. Sparse component analysis is combined with single component points (SCPs) to blind decomposition of mixtures data X into pure components S and concentration matrix A, whereas the number of pure components S is greater than number of mixtures X. NMR mixtures are transformed into wavelet domain, where pure components are sparser than in time domain and where SCPs are detected. Mass spectrometry (MS) mixtures are extended to analytical continuation in order to detect SCPs. SCPs are used to estimate number of pure components and concentration matrix. Pure components are estimated in frequency domain (NMR data) or m/z domain (MS data) by means of constrained convex programming methods. Estimated pure components are ranked using negentropy-based criterion.

Abstract: Aamantane dipyrromethane derivatives are obtained by reacting adamantane carbonyl derivatives with pyrrole or pyrrole derivative, in the presence of acid. Adamantane-dipyrromethanes are used to bind anions of the group consisting of: F—, Cl—, Br—, acetate, HSO4-NO3-, and H2PO4-, and particularly F—.

Abstract: The present invention provides a mixed bacterial culture, designated as the culture Atz Mix 1, which degrades atrazine at various temperatures (10° C. to 30° C.) in a wide range of atrazine concentrations (several ppb to ten thousand ppm), without formation of toxic metabolites. Atz Mix 1 is a stable mixed culture and includes catabolic genes trzN, atzB, atzC coding the enzymes for the degradation of atrazine to cyanuric acid, and the gene trzD coding the enzymes for subsequent opening of s-triazine ring. The invention further includes a microbiological method of degrading atrazine and other s-triazine compounds for remediation of atrazine-contaminated soils, even those rich in nitrogen, as well as for accelerating the process of atrazine mineralization in waste waters containing high concentrations of s-triazine compounds.