Abstract: The present disclosure provides a hydrogel composition comprising an interpenetrating polymer network (IPN) containing a biopolymer, a first synthetic polymer and a second synthetic polymer in which a contained community of live human MSCs is embedded. The collagen polymer matrix described (a) allows the embedded cells to remain in place or to migrate over short distances; (b) allows diffusion of small molecules, particularly growth factors produced by the cells or provided as a supplement, and EVs released by the cells to support the recovery of periodontium tissue function following injury.

Abstract: A corneal device comprising a base surface and a top surface, and having a water content ranging from about 78%-92% (w/w), inclusive. The corneal device can be used to treat, for example without limitation, ectatic corneal disease by supporting corneal structure weakened by the disease and/or changing an anterior curvature of the cornea.

Abstract: Methods of manufacturing and implanting corneal inlays, such as small diameter corneal inlays, are provided. The methods include manufacturing an implant body to have a meniscus shape with a small diameter and an index of refraction, and implanting the implant body in a corneal bed of a cornea. The inlays cause a change in an anterior surface of the cornea after implantation due to the implant body.

Abstract: Methods of manufacturing a corneal implant that include creating an implant body that has a meniscus shape, a diameter of approximately 2.5 mm or less, and an index of refraction of 1.376. The implant body can further have a central thickness and an outer edge thickness.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: Methods of treating presbyopia of an eye. A corneal inlay is inserted within the cornea such that the central thickness of the corneal inlay is 3 to 7 times a central elevation change.